Osseointegration of titanium implants in the tibia: Electron microscopy of biopsies from 4 patients

Serre, Claire-Marie; Boivin, Georges; Obrant, Karl; Linder, Lars

doi:10.3109/17453679408995462

Cited by 25 publications

(11 citation statements)

References 13 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This more or less amorphous layer seems to constitute one part of the interface and can contribute to the nonelastic behavior of the interface. Mineralized bone has been reported to be in direct contact with the implant surface (21); hence, the anatomy of the interface is complex.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical characterization of osseointegration: An experimental in vivo investigation in the beagle dog

Brånemark

Öhrnell

Skalak

et al. 1998

Journal Orthopaedic Research

101

View full text Add to dashboard Cite

This study reports the results of torsion tests, pull-out tests, and lateral loading tests on osseointegrated commercially pure titanium fixtures. The tests were performed in vivo on six beagle dogs. Three fixtures, each with a diameter of 3.7 mm, were installed bilaterally in the tibia of each animal. The mean maximal pull-out load was 1.55 kN (n = 4), the mean maximal lateral transverse load was 0.21 kN (n = 2), the mean maximal lateral axial load was 0.18 kN (n = 2), the mean breakpoint torque was 0.31 Nm (n = 3), and the mean maximal torque was 0.43 Nm (n = 3). The torsion test revealed an almost immediate plastic deformation of the interface between the implant and bone; this indicates that although the contact between the bone and the implant is close, there is no strong bond, at least not in shear. The major transfer of load from the implant to the surrounding bone tissue must therefore depend on the design of the implant. A histological evaluation with measurements of the amount of bone in contact with the fixtures was performed. By the use of the histological and mechanical data, it is possible to estimate shear stresses in bone tissue (pull-out test) and in the interface (torque test). The mean maximal shear stress in bone tissue in the pull-out tests was 100 MPa (n = 4); the mean shear stress in the interface was 4.3 MPa (n = 3) in the torsion tests at the breakpoint torque and was 6.0 MPa (n = 3) at the maximal torque. It was also possible to estimate the shear modulus of elasticity in the pull-out and torque tests. The mean shear modulus in pull-out was 119 MPa (n = 4), and the mean apparent shear modulus in torsion was 9 kPa (n = 3) for an assumed interface thickness of 100 nm and was 86 kPa (n = 3) for an assumed interface thickness of 1,000 nm.

show abstract

Section: Discussionmentioning

confidence: 99%

Biomechanical characterization of osseointegration: An experimental in vivo investigation in the beagle dog

Brånemark

Öhrnell

Skalak

et al. 1998

Journal Orthopaedic Research

101

View full text Add to dashboard Cite

show abstract

“…Through the presence of osteocytes adjacent to the implant surface after prolonged healing periods, early investigators demonstrated that peri-implant bone around metals is indeed a living tissue ( Serre et al 1994 ). The inner wall of the osteocyte lacuna exhibits basophilic staining properties similar to the osteoid-like matrix interposed between mineralized bone and the implant surface ( Piattelli et al 1994 ).…”

Section: Osteocytes and Implant Biomaterialsmentioning

confidence: 99%

A Review of the Impact of Implant Biomaterials on Osteocytes

2018

View full text Add to dashboard Cite

In lamellar bone, a network of highly oriented interconnected osteocytes is organized in concentric layers. Through their cellular processes contained within canaliculi, osteocytes are highly mechanosensitive and locally modulate bone remodeling. We review the recent developments demonstrating the significance of the osteocyte lacuno-canalicular network in bone maintenance around implant biomaterials. Drilling during implant site preparation triggers osteocyte apoptosis, the magnitude of which correlates with drilling speed and heat generation, resulting in extensive remodeling and delayed healing. In peri-implant bone, osteocytes physically communicate with implant surfaces via canaliculi and are responsive to mechanical loading, leading to changes in osteocyte numbers and morphology. Certain implant design features allow peri-implant osteocytes to retain a less aged phenotype, despite highly advanced extracellular matrix maturation. Physicochemical properties of anodically oxidized surfaces stimulate bone formation and remodeling by regulating the expression of RANKL (receptor activator of nuclear factor–κB ligand), RANK, and OPG (osteoprotegerin) from implant-adherent cells. Modulation of certain osteocyte-related molecular signaling mechanisms (e.g., sclerostin blockade) may enhance the biomechanical anchorage of implants. Evaluation of the peri-implant osteocyte lacuno-canalicular network should therefore be a necessary component in future investigations of osseointegration to more completely characterize the biological response to materials for load-bearing applications in dentistry and orthopedics.

show abstract

“…Biocompatibility . The biological response to titanium and cobalt-chrome alloys have been studied extensively and their biocompatibility has been demonstrated to be favorable 45,46,207,348 . In an early study, Brånemark described the concept of osseointegration and suggested that direct contact between titanium implants and bone at LM Biomaterials level was achieved 30,31 .…”

Section: Metalsmentioning

confidence: 99%

Calcium phosphate coatings for fixation of bone implants. Evaluated mechanically and histologically by stereological methods

Overgaard¹

2001

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

show abstract

Osseointegration of titanium implants in the tibia: Electron microscopy of biopsies from 4 patients

Cited by 25 publications

References 13 publications

Biomechanical characterization of osseointegration: An experimental in vivo investigation in the beagle dog

Biomechanical characterization of osseointegration: An experimental in vivo investigation in the beagle dog

A Review of the Impact of Implant Biomaterials on Osteocytes

Calcium phosphate coatings for fixation of bone implants. Evaluated mechanically and histologically by stereological methods

Contact Info

Product

Resources

About