Calcium phosphate coatings for fixation of bone implants. Evaluated mechanically and histologically by stereological methods

Overgaard, Søren

doi:10.1080/000164702760300297

Cited by 10 publications

(5 citation statements)

References 334 publications

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“…3,4 Significant loss of the HA coating on both immobilised and continuously loaded implants has been demonstrated in vivo. 5 Fractures between the coating and the Ti6Al4V substrate have been observed after implantation times as short as 12 weeks and as long as one year; 6,7 the primary reason for the failure at the interface is the residual stress due to the mismatch of the coefficients of thermal expansion (CTE) of the ceramic and metal components, which can induce micro-cracking initiating the de-bonding of the coating from the substrate. [8][9][10] The micro-cracking of silicate glass coatings on Ti6Al4V substrates due to mismatch of CTE has also been recorded.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and osteo-stimulatory effects of a borate-based glass series doped with strontium ions

Stone

Schemitsch

et al. 2016

J Biomater Appl

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This work considered the effect of both increasing additions of Strontium (Sr) and incubation time on solubility and both antibacterial and osteo-stimulatory effects of a series of glasses based on the BO-PO-CaCO-NaCO-TiO-SrCO series. The amorphous nature of all the glasses was confirmed by X-ray diffraction. Discs of each glass were immersed in de-ionized water for 1, 7 and 30 days, and the water extracts were used for ion release profiles, pH measurements and cytotoxicity testing. Atomic absorption spectroscopy was employed to detect the release of Na, Ca and Sr ions from the glasses with respect to maturation, which indicated that the addition of Sr retarded solubility of the glass series. This effect was also confirmed by weight loss analysis through comparing the initial weight of glass discs before and after periods of incubation. The incorporation of Sr in the glasses did not influence the pH of the water extracts when the glasses were stored for up to 30 days. Cytotoxicity testing with an osteoblastic cell line (MC3T3-E1) indicated that glasses with the higher (20 mol% and 25 mol%) Sr incorporation promoted proliferation of osteoblast cells, while the glasses with lower Sr contents inhibited cell growth. The glass series, except for Ly-B5 (which contained the highest Sr incorporation; 25 mol%), were bacteriostatic against S. aureus in the short term (1-7 days) as a result of the dissolution products released.

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Section: Introductionmentioning

confidence: 99%

Antibacterial and osteo-stimulatory effects of a borate-based glass series doped with strontium ions

Stone

Schemitsch

et al. 2016

J Biomater Appl

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“…Satisfactory to excellent results were reported when adequate stem anchorage was obtained [15,[19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Good results with an uncoated grit-blasted tapered straight stem at ten years

Zweymüller

2007

Interact Surg

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In the literature, there is no consensus on the value of uncoated cementless femoral stems. We asked whether the results obtained with a grit-blasted titanium surface would prove the usefulness of this implant at an intermediate follow-up time. Three hundred and sixty five patients (376 hips) underwent primary total hip arthroplasty (THA) using the SL-Plus stem in combination with a ceramic-PE articulation. At a minimum follow-up time of 10.0 years (mean 10.2 years; range, 10.0 to 12.6 years), 229 stems (60.9%) were available for analysis. Five revisions were performed, one because of low-grade infection, one because of an aseptic loosening, another one because of a traumatic subsidence and two because of periprosthetic fractures. The 10-year survivorship with revision for any reason as event of interest was 98.3% (95% CI: 96.0%-99.3%). Radiologically two stems were diagnosed to be loosened at follow-up. Osteolytic lesions were detected in 5 patients. The implant survivorship with revision and radiographic sign of loosening as event of interest was 95.7% (95% CI: 89.0%-98.4%) at the time of maximum follow-up (12.6 years). Radiolucent lines (RLs) occurred in 27.9% mostly in positions 1 and 7. In the age group less than 70 years of age, 35% were found to show RLs, in the age group older than 70 years of age only 12.5% showed RLs. The five patients with osteolytic lesions were all from the age group 70 years. These intermediate results document that primary implants with a grit-blasted titanium surface ensure an excellent intermediate-term outcome clinically and with regards to the survival rate. It also confirms our approach not to accept any age limits for selecting patients for cementless THAs. A prospective study will have to show whether additional hydroxyapatite (HA)-coating can improve the radiologic outcome.

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“…The SD was set to 50%, and a MIREDIF of 80% was selected. At least six samples per group were needed according to assumptions 36 . To account for dropout, two additional sheep were added, so eight sheep per group were included.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of marine bioactive compound fucoidan for bone regeneration and implant fixation in sheep

Nielsen

Mikkelsen

Ptak

et al. 2021

J Biomedical Materials Res

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The need for a substitute for allograft and autograft is rising as bone graft surgeries exceed available supplies. We investigated the efficacy of the low‐molecular weight marine bioactive compound fucoidan (FUC) on bone regeneration and implant fixation in seven female sheep, as FUC has shown great promise as a bone substitute. Titanium implants were inserted bilaterally in the distal femurs to test three hydroxyapatite/fucoidan (HA/FUC) groups and compared to allograft. The HA was coated with either 500 or 1500 μg of FUC, obtained by microwave‐assisted chemical extraction, or 500 μg of FUC obtained by an enzyme‐assisted extraction method. The concentric 2‐mm gap around the implant was filled with either one of the HA/FUCs or allograft from the donor sheep. After 12 weeks, implant–bone blocks were harvested and divided into three parts for mechanical push‐out testing, immunohistochemistry, and micro‐CT and histomorphometry. Pronounced bone formations were observed by micro‐CT and histomorphometry in all groups, but higher bone volume fractions were seen in the allograft group compared to the three HA/FUC groups. The trabecular thickness, trabecular separation, and architectural anisotropy were all significantly higher in the allograft group compared to the three HA/FUC groups. In conclusion, adequate bone formation was observed in all groups, although the bone formation was significantly greater in the allograft group. Also, no significant differences existed in the shear mechanical properties between groups, suggesting that the combination of HA and FUC can achieve a similar fixation strength to allograft in this model.

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Calcium phosphate coatings for fixation of bone implants. Evaluated mechanically and histologically by stereological methods

Cited by 10 publications

References 334 publications

Antibacterial and osteo-stimulatory effects of a borate-based glass series doped with strontium ions

Antibacterial and osteo-stimulatory effects of a borate-based glass series doped with strontium ions

Good results with an uncoated grit-blasted tapered straight stem at ten years

Efficacy of marine bioactive compound fucoidan for bone regeneration and implant fixation in sheep

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