A Review of the Impact of Implant Biomaterials on Osteocytes

Shah, Furqan A.; Thomsen, Peter; Palmquist, Anders

doi:10.1177/0022034518778033

Cited by 69 publications

(54 citation statements)

References 61 publications

(115 reference statements)

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“…Osteocytes are important indicators of bone tissue quality and are also important structural markers of osseointegration. In addition, osteocytes are exceptionally valuable in characterizing bone tissue response to implanted materials [34,39]. Thus, we can cite, one of the limitations of the present study was to evaluate through immunohistochemical assay the amount of osteocytes around the different groups of implants used.…”

Section: Discussionmentioning

confidence: 86%

“…Then, the physicochemical properties of the material can stimulate bone formation and remodeling by regulating the expression of RANKL (receptor activator of nuclear factor-κB ligand), RANK, and OPG (osteoprotegerin) from implant-adherent cells. Modulation of certain osteocyte-related molecular signaling mechanisms (e.g., sclerostin blockade) may enhance the biomechanical anchorage of implants [34]. Moreover, certain implant design features allow peri-implant osteocytes to retain a less aged phenotype, despite highly advanced extracellular matrix maturation.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, we can cite, one of the limitations of the present study was to evaluate through immunohistochemical assay the amount of osteocytes around the different groups of implants used. This information would be of great importance because in the bone tissue surrounding the implants, osteocytes physically communicate with implant surfaces through the canaliculi and respond to mechanical loading (e.g., bone compression during the implant insertion), leading to changes in osteocyte numbers and morphology [34].…”

Section: Discussionmentioning

confidence: 99%

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New Implant Macrogeometry to Improve and Accelerate the Osseointegration: An In Vivo Experimental Study

et al. 2019

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A new implant design with healing chambers in the threads was analyzed and compared with a conventional implant macrogeometry, both implants models with and without surface treatment. Eighty conical implants were prepared using commercially pure titanium (grade IV) by the company Implacil De Bortoli (São Paulo, Brazil). Four groups were performed, as described below: Group 1 (G1), traditional conical implants with surface treatment; group 2 (G2), traditional conical implants without surface treatment (machined surface); group 3 (G3), new conical implant design with surface treatment; group 4 (G4), new conical implant design without surface treatment. The implants were placed in the two tibias (n = 2 implants per tibia) of twenty New Zealand rabbits determined by randomization. The animals were euthanized after 15 days (Time 1) and 30 days (Time 2). The parameters evaluated were the implant stability quotient (ISQ), removal torque values (RTv), and histomorphometric evaluation to determine the bone to implant contact (%BIC) and bone area fraction occupancy (BAFO%). The results showed that the implants with the macrogeometry modified with healing chambers in the threads produced a significant enhancement in the osseointegration, accelerating this process. The statistical analyses of ISQ and RTv showed a significative statistical difference between the groups in both time periods of evaluation (p ≤ 0.0001). Moreover, an important increase in the histological parameters were found for groups G3 and G4, with significant statistical differences to the BIC% (in the Time 1 p = 0.0406 and in the Time 2 p < 0.0001) and the BAFO% ((in the Time 1 p = 0.0002 and in the Time 2 p = 0.0045). In conclusion, the result data showed that the implants with the new macrogeometry, presenting the healing chambers in the threads, produced a significant enhancement in the osseointegration, accelerating the process.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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New Implant Macrogeometry to Improve and Accelerate the Osseointegration: An In Vivo Experimental Study

et al. 2019

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“…Elgali et al () also demonstrated that synthetically produced α‐TCP/octacalcium phosphate based, degradable implant material supports the formation of osteocyte–containing mineralized tissue. Furthermore, autogenous bone fragments generated during implant site preparation also may enhance the formation of new bone (Shah & Palmquist, ; Shah, Thomsen, & Palmquist, ). These results stayed consistent with our studies.…”

Section: Discussionmentioning

confidence: 99%

In vivo behavior of biomicroconcretes based on α‐tricalcium phosphate and hybrid hydroxyapatite/chitosan granules and sodium alginate

Zima

Czechowska

Szponder

et al. 2020

J Biomedical Materials Res

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The current studies provide insights into how predictions based on results of physicochemical and in vitro tests are consistent with the results of in vivo studies. The new biomicroconcrete type materials were obtained by mixing the solid phase, composed of hybrid hydroxyapatite/chitosan granules and highly reactive α‐tricalcium phosphate powder, used as the setting agent. This approach guaranteed a good adhesion of the continuous cement phase to the surface of granules. It has been demonstrated that developed biomicroconcretes are surgically handy, possessed favorable physicochemical and biological properties and can be considered as effective bone implant material. The hierarchical porosity and compressive strength (2–6 MPa) similar to cancellous bone made them suitable for low‐load bearing applications. Despite the fact that final setting times of biomicroconcretes were longer than recommended in the literature (i.e., exceeded 15 min), their short cohesion time allows for a successful implantation in a rabbit femoral defect model. Histological analysis and Raman studies revealed newly formed bone tissues around the sides of implanted materials. Furthermore, the process of neovascularization and reconstruction of the bone tissue, as well as a reverse scaffolding process, was visible. No signs of inflammation or adverse tissue reactions were observed during the experiment.

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“…Among the mechanical properties that are considered when evaluating a biomaterial is the longitudinal elasticity module. If the biomaterial is used for orthopedic implants, it must have a modulus of longitudinal elasticity equivalent to that of the bone, which varies between 4 and 30 GPa, depending on the type of bone and the direction of measurement [14,16,17].…”

Section: Microindentation Methodsmentioning

confidence: 99%

Development of New Advanced Ti-Mo Alloys for Medical Applications

Vizureanu¹,

Bălțatu²,

Sandu³

2020

Biomaterials

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The use of titanium and titanium-based alloys with applications in implantology and dentistry has made remarkable progress in the promotion of new technologies and new materials that have been developed in recent years. This is justified thanks to their excellent mechanical, physical, and biological performance. Today's generation promotes new titanium alloys, with nontoxic elements and long-term performance and without rejection of the human body. This book chapter describes new original compositions of Ti-based alloys for medical applications, with improved properties compared to existing classical alloys (C.p. Ti, Ti6Al4V, CoCrMo, etc.). The addition of nontoxic elements such as Mo, Si, Zr, and Ta brings benefits as reduced modulus of elasticity, increased corrosion resistance, and improved biocompatibility.

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A Review of the Impact of Implant Biomaterials on Osteocytes

Cited by 69 publications

References 61 publications

New Implant Macrogeometry to Improve and Accelerate the Osseointegration: An In Vivo Experimental Study

New Implant Macrogeometry to Improve and Accelerate the Osseointegration: An In Vivo Experimental Study

In vivo behavior of biomicroconcretes based on α‐tricalcium phosphate and hybrid hydroxyapatite/chitosan granules and sodium alginate

Development of New Advanced Ti-Mo Alloys for Medical Applications

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