Osseointegration of sputtered SiC-added hydroxyapatite for orthopaedic applications

Vrânceanu, Diana Maria; Cotruț, Cosmin Mihai; Bramowicz, Mirosław; Titorencu, Irina; Kulesza, Sławomir; Kiss, A.; Berbecaru, Andrei; Prună, Vasile; Brânzei, Mihai; Vlădescu, Alina

doi:10.1016/j.ceramint.2016.03.114

Cited by 37 publications

(20 citation statements)

References 43 publications

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“…In our previous papers [33][34][35], we aimed and succeeded to enhance the mechanical properties of sputtered hydroxyapatite coatings by adding SiC into their structure without affecting their osseointegration and bioactive characteristics. According to our studies, SiC addition improved the hardness and elastic modulus of HAp coating, this being a positive effect for materials used in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

et al. 2019

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Considering the requirements of medical implantable devices, it is pointed out that biomaterials should play a more sophisticated, longer-term role in the customization and optimization of the material–tissue interface in order to ensure the best long-term clinical outcomes. The aim of this contribution was to assess the performance of silicon carbide–hydroxyapatite in various simulated biological fluids (Dulbecco’s modified Eagle’s medium (DMEM), simulated body fluid (SBF), and phosphate buffer solution (PBS)) through immersion assays for 21 days at 37 ± 0.5 °C and to evaluate the electrochemical behavior. The coatings were prepared on Ti6Al4V alloy substrates by magnetron sputtering method using two cathodes made of hydroxyapatite and silicon carbide (SiC). After immersion assays the coating’s surface was analyzed in terms of morphology, chemical and phase composition, and chemical bonds. According to the electrochemical behavior in the media investigated at 37 ± 0.5 °C, SiC addition inhibits the dissolution of the hydroxyapatite in DMEM acellular media. Furthermore, after adding SiC, the slow degradation of hydroxyapatite in PBS and SBF media as well as biomineralization in DMEM were observed.

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Section: Introductionmentioning

confidence: 99%

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

et al. 2019

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“…This compound promotes protein adhesion, and improves the mechanical properties of potential implant materials [37]. In our previous paper, we showed that the addition of Si improves the bioactivity and resistance of HAP in artificial saliva, thus being a good solution for dental implants [38]. Moreover, hardness and elastic modulus were increased by adding Si to the basic HAP structure [39].…”

Section: Introductionmentioning

confidence: 99%

Sputtered Si and Mg doped hydroxyapatite for biomedical applications

et al. 2018

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Hydroxyapatite (HAP) coatings are applied on metallic implant materials to combine mechanical properties of metallic material with bioactivity abilities of HAP ceramic. In this study, HAP coatings with additions of Si and Mg are proposed to be deposited on Ti6Al4V substrates by RF magnetron sputtering. Chemical bonding, morphology, topography and corrosion resistance in simulated body fluids (SBF) of the coatings were investigated. Additionally, mechanical and biological properties of the coatings were evaluated. It was found that the addition of Si and Mg does not influence the formation of a HAP phase. All the coatings exhibited smooth surface and uniform growth, without defects or cracks. Both hardness and elastic modulus of the coated samples decrease with Mg addition in the HAP-Si structure. Both Mg and Si addition into HAP coatings were found to enhance the corrosion resistance of the Ti6Al4V alloy in the SBF solution. Coatings with low Mg content exhibited better corrosion performance. All the coatings investigated were biocompatible, as demonstrated by SaOS-2 bone cell attachment and growth. However, cell proliferation and morphology were inferior on samples with the highest Mg content.

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“…Our previous studies demonstrated that the corner frequency is found similar to average decay length, and hence to average grain diameter [28,29]. As a quick characterization tool, fractal analysis proved to be useful in studies of morphology and mechanical properties of various surface structures upon heat treatment [30][31][32], nanomechanical processing [33,34], in contact with body tissues and fluids [35][36][37][38]. Obtained results established a bridge between specific geometry of residual surface and its tribological and physical characteristics [39][40][41].…”

Section: Surface Texture Analysis From Afmmentioning

confidence: 78%

Micromorphology analysis of sputtered indium tin oxide fabricated with variable ambient combinations

et al. 2018

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Osseointegration of sputtered SiC-added hydroxyapatite for orthopaedic applications

Cited by 37 publications

References 43 publications

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

Sputtered Si and Mg doped hydroxyapatite for biomedical applications

Micromorphology analysis of sputtered indium tin oxide fabricated with variable ambient combinations

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