Sputtered Si and Mg doped hydroxyapatite for biomedical applications

Abstract

Hydroxyapatite (HAP) coatings are applied on metallic implant materials to combine mechanical properties of metallic material with bioactivity abilities of HAP ceramic. In this study, HAP coatings with additions of Si and Mg are proposed to be deposited on Ti6Al4V substrates by RF magnetron sputtering. Chemical bonding, morphology, topography and corrosion resistance in simulated body fluids (SBF) of the coatings were investigated. Additionally, mechanical and biological properties of the coatings were evaluated. It was found that the addition of Si and Mg does not influence the formation of a HAP phase. All the coatings exhibited smooth surface and uniform growth, without defects or cracks. Both hardness and elastic modulus of the coated samples decrease with Mg addition in the HAP-Si structure. Both Mg and Si addition into HAP coatings were found to enhance the corrosion resistance of the Ti6Al4V alloy in the SBF solution. Coatings with low Mg content exhibited better corrosion performance. All the coatings investigated were biocompatible, as demonstrated by SaOS-2 bone cell attachment and growth. However, cell proliferation and morphology were inferior on samples with the highest Mg content.

Impact and biocompatibility studies on Mg2+‐substituted Apatite‐derived 3D porous scaffolds for hard tissue engineering

“…19,20 In this context an attempt have been made to fabricate Mg 2+ substituted Apatite porous scaffold through slip-casting technique. 19,20 In this context an attempt have been made to fabricate Mg 2+ substituted Apatite porous scaffold through slip-casting technique.…”

“…Apatite lattice, decrease in crystallinity which leads to the better bioactivity. 19,20 In this context an attempt have been made to fabricate Mg 2+ substituted Apatite porous scaffold through slip-casting technique. Different fabricating techniques such as gel casting, slip-casting, freeze casting, gas foaming, and rapid prototyping have been used for the preparation of porous scaffolds.…”

Considerations and Influencing Parameters in EDS Microanalysis of Biogenic Hydroxyapatite

“…In the biomedical field, elemental EDS analysis is used for many purposes, including the detection of heavy residual elements in tissues and organs [13], the analysis of mineral deposits (stones formed in various organs) and calcified tissues present in the body (Ca, P, Mg) [14] with supporting role in the skeletal system [14,15]. Numerous studies have approached both morphological [16] and compositional [17,18] methods for the analysis of calcium phosphate composition [19][20][21]. In some studies, EDS analysis was used to evaluate the chemical composition of the median aortic calcification [22] and the genesis of Ca and P deposits in atheroma plaques [23].…”

Synthesis and Properties of Zinc-Modified Hydroxyapatite

“…An important advantage of these materials over classical materials intended for artificial bone implants is biochemical compatibility, expressed in a lower intensity of inflammatory reactions in the tissues surrounding the implant. The limitation, in terms of autografts and allografts, has forced scientists to develop various synthetic-doped/substituted hydroxyapatites as an alternative [1][2][3][4][5][6].…”