Osseointegration aspects of placed implant in bone reconstruction with newly developed block-type interconnected porous calcium hydroxyapatite

Doi, Katsuhiko; Kubo, Takayasu; Makihara, Yusuke; Oue, Hiroshi; Morita, Koji; Oki, Yoshio; Kajihara, Shiho; Tsuga, Kazuhiro

doi:10.1590/1678-775720150597

Cited by 13 publications

(25 citation statements)

References 31 publications

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“…Normally, RT is strongly infl uenced by cortical bone integration and strongly correlates with the BIC ratio 22) . In our previous study on implant placement at sites reconstructed with IP-CHA, the BIC ratio was not significantly different between the grafted IP-CHA site and the parent bone site 13) . Regarding the results of the histological observation, newly formed bone was detected in the gaps between the implant threads at the test site reconstructed with IP-CHA.…”

Section: Discussionmentioning

confidence: 64%

“…In our previous study, connective and bone tissues were detected in the central portion of grafted IP-CHA in in vivo studies 11,12) . Furthermore, the newly formed bone ratio for grafted IP-CHA at 24 weeks was greater than that at 12 weeks in an animal model using a canine femur 13) . These fi ndings indicated that osteoconduction progressed continuously at the grafted IP-CHA site.…”

Section: Discussionmentioning

confidence: 84%

“…These findings indicate that bone reconstruction sites would achieve osseointegration after implant placement. In fact, our pilot study demonstrated that osseointegration of placed implants could be detected at a site reconstructed with IP-CHA as well as at a parent bone site 13) . However, the evaluation was limited by the histological observation method, and implant stability has not yet been assessed at sites where bone was reconstructed with IP-CHA.…”

Section: Introductionmentioning

confidence: 76%

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Stability of Implants Placed in Bone Reconstructed with Block-type Interconnected Porous Hydroxyapatite

Makihara

Doi

Oki

et al. 2017

J. Hard Tissue Biology.

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Artificial bone has been applied to reconstruct bone defects. However, few reports have evaluated implant stability or implant placement after grafting block-type artifi cial bone. Interconnected porous hydroxyapatite (IP-CHA) has the superior advantage of osteoconduction ability because of porous and interconnected structure. The purpose of this study was to evaluate the stability of implants placed in bone reconstructed with an IP-CHA block. IP-CHA cylinders (D; 6.0 mm, H; 12.0 mm) were grafted into bone sockets in the right femurs of three male dogs. After 3 months, an implant was placed into a socket that was prepared in the central portion of the grafted IP-CHA on the right side, then implants were placed in the sockets (test-group). Simultaneously, an implant was placed into the parent bone of the left femur (control-group). The implant stability quotient (ISQ) was measured immediately after placement. Twelve weeks after implant placement, ISQ and removal torque (RT) measurements were performed to assess implant stabilities. ISQ values in the test-group after 12 weeks were signifi cantly higher than those at the time of placement in the test and control groups (P<0.05). RT was not signifi cantly diff erent between bone sites reconstructed with IP-CHA and parent bone sites. At sites reconstructed with IP-CHA, bone formation was detected around the implant socket. The data indicate that favorable implant stability was achieved at sites reconstructed using an IP-CHA as well as at control. These results showed IP-CHA might be a useful type of artifi cial bone for preliminary bone reconstruction in implant therapy.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 76%

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Stability of Implants Placed in Bone Reconstructed with Block-type Interconnected Porous Hydroxyapatite

Makihara

Doi

Oki

et al. 2017

J. Hard Tissue Biology.

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“…As resulting from the table previously described, the alveolar preparation performed with drills for osseodensification allows us to increase the surface of contact between the surface of the implant and the autologous bone of the patient [ 66 , 70 , 71 , 73 , 74 , 75 ]. Moreover, we may consider how the use of drills for osseodensification with anticlockwise movement (REVERSE) allows us to preserve and compact the residue bone in the immediate proximity of the implant in a more effective way than the use of clockwise movement [ 64 , 68 , 69 , 71 , 72 , 73 ].…”

Section: Resultsmentioning

confidence: 99%

The Effectiveness of Osseodensification Drilling Protocol for Implant Site Osteotomy: A Systematic Review of the Literature and Meta-Analysis

Inchingolo

Bordea

et al. 2021

Materials

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Many different osteotomy procedures has been proposed in the literature for dental implant site preparation. The osseodensification is a drilling technique that has been proposed to improve the local bone quality and implant stability in poor density alveolar ridges. This technique determines an expansion of the implant site by increasing the density of the adjacent bone. The aim of the present investigation was to evaluate the effectiveness of the osseodensification technique for implant site preparation through a literature review and meta-analysis. The database electronic research was performed on PubMed (Medline) database for the screening of the scientific papers. A total of 16 articles have been identified suitable for the review and qualitative analysis—11 clinical studies (eight on animals, three on human subjects), four literature reviews, and one case report. The meta-analysis was performed to compare the bone-to-implant contact % (BIC), bone area fraction occupied % (BAFO), and insertion torque of clockwise and counter-clockwise osseodensification procedure in animal studies. The included articles reported a significant increase in the insertion torque of the implants positioned through the osseodensification protocol compared to the conventional drilling technique. Advantages of this new technique are important above all when the patient has a strong missing and/or low quantity of bone tissue. The data collected until the drafting of this paper detect an improvement when the osseodensification has been adopted if compared to the conventional technique. A significant difference in BIC and insertion torque between the clockwise and counter-clockwise osseodensification procedure was reported, with no difference in BAFO measurements between the two approaches. The effectiveness of the present study demonstrated that the osseodensification drilling protocol is a useful technique to obtain increased implant insertion torque and bone to implant contact (BIC) in vivo. Further randomized clinical studies are required to confirm these pieces of evidence in human studies.

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“…HA with a porous structure shows superior osteoconduction because it has an interconnected structure, which allows for the efficient migration of osteogenic cells and vascularization from surrounding bone [ 1 , 2 ]. Interconnected porous hydroxyapatite (IP-CHA), a type of porous HA, has a systematic arrangement of uniform pores with interconnections, and has been successfully used as a bone graft material for tissue engineering [ 3 , 4 , 5 ]. Despite the superior osteoconduction of porous HA, the ability of bone regeneration is not predictable, owing to the lack of stimulation abilities of bone formation.…”

Section: Introductionmentioning

confidence: 99%

Novel Development of Phosphate Treated Porous Hydroxyapatite

et al. 2017

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Phosphoric acid-etching treatment to the hydroxyapatite (HA) surface can modify the solubility calcium structure. The aim of the present study was to develop phosphate treated porous HA, and the characteristic structures and stimulation abilities of bone formation were evaluated to determine its suitability as a new type of bone graft material. Although the phosphoric acid-etching treatment did not alter the three-dimensional structure, a micrometer-scale rough surface topography was created on the porous HA surface. Compared to porous HA, the porosity of phosphate treated porous HA was slightly higher and the mechanical strength was lower. Two weeks after placement of the cylindrical porous or phosphate treated porous HA in a rabbit femur, newly formed bone was detected in both groups. At the central portion of the bone defect area, substantial bone formation was detected in the phosphate treated porous HA group, with a significantly higher bone formation ratio than detected in the porous HA group. These results indicate that phosphate treated porous HA has a superior surface topography and bone formation abilities in vivo owing to the capacity for both osteoconduction and stimulation abilities of bone formation conferred by phosphoric acid etching.

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Osseointegration aspects of placed implant in bone reconstruction with newly developed block-type interconnected porous calcium hydroxyapatite

Cited by 13 publications

References 31 publications

Stability of Implants Placed in Bone Reconstructed with Block-type Interconnected Porous Hydroxyapatite

Stability of Implants Placed in Bone Reconstructed with Block-type Interconnected Porous Hydroxyapatite

The Effectiveness of Osseodensification Drilling Protocol for Implant Site Osteotomy: A Systematic Review of the Literature and Meta-Analysis

Novel Development of Phosphate Treated Porous Hydroxyapatite

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