Stability of Implants Placed in Bone Reconstructed with Block-type Interconnected Porous Hydroxyapatite

Abstract

Artificial bone has been applied to reconstruct bone defects. However, few reports have evaluated implant stability or implant placement after grafting block-type artifi cial bone. Interconnected porous hydroxyapatite (IP-CHA) has the superior advantage of osteoconduction ability because of porous and interconnected structure. The purpose of this study was to evaluate the stability of implants placed in bone reconstructed with an IP-CHA block. IP-CHA cylinders (D; 6.0 mm, H; 12.0 mm) were grafted into bone sockets in the right femurs of three male dogs. After 3 months, an implant was placed into a socket that was prepared in the central portion of the grafted IP-CHA on the right side, then implants were placed in the sockets (test-group). Simultaneously, an implant was placed into the parent bone of the left femur (control-group). The implant stability quotient (ISQ) was measured immediately after placement. Twelve weeks after implant placement, ISQ and removal torque (RT) measurements were performed to assess implant stabilities. ISQ values in the test-group after 12 weeks were signifi cantly higher than those at the time of placement in the test and control groups (P<0.05). RT was not signifi cantly diff erent between bone sites reconstructed with IP-CHA and parent bone sites. At sites reconstructed with IP-CHA, bone formation was detected around the implant socket. The data indicate that favorable implant stability was achieved at sites reconstructed using an IP-CHA as well as at control. These results showed IP-CHA might be a useful type of artifi cial bone for preliminary bone reconstruction in implant therapy.

Osseointegration Aspects of Implants at the Bone Reconstruction Site by a Novel Porous Titanium Scaffold

“…These higher BA and BIC values in the lower portion suggest that porous biomaterials with excellent osteoconduction can achieve bone ingrowth from the surrounding pristine bone even in the cancellous BA and the bone marrow tissue. These results are consistent with that of our previous studies [10,21] where bone formation was detected not only in the cortical bone portion of the porous HA but also inside the part that was located in the bone cancellous BA. Furthermore, we placed the implants in the pristine bone sites and reconstructed them using porous HA sites.…”

“…Furthermore, HA, with its porous structure, facilitates implant placement after reconstruction due to the ingrowth of bone within the grafted material [6][7][8]. Our previous studies [9,10] demonstrated osseointegration of implants after the reconstruction of the preliminary bone site with interconnected porous HA. Despite the high biocompatibility and excellent osteoconduction ability of HA, it is not suitable for the reconstruction of large-size bone defects due to its insufficient mechanical strength.…”

Comparative Implant Stability of a Novel Implant-Porous Titanium Complex and an Implant-Porous Hydroxyapatite Complex for Bone Reconstruction Material

“…In contrast, the implant-porous hydroxyapatite complex, which is a bioactive material, also induces bone formation in the bone marrow region. In our previous study, we reported that porous hydroxyapatite with excellent bone conduction achieved osteogenesis even at the site of the bone marrow cavity 6,25,26) .…”

Histological and histomorphometric aspects of continual intermittent parathyroid hormone administration on osseointegration in osteoporosis rabbit model

“…During implantation, the maximum insertion torque (IT) was recorded to evaluate primary stability using an implant surgical motor device (iChiropro, Bien-air, Bienne, Bern, Switzerland). Four weeks after implant placement, the maximum removal torque (RT) of femurs with implants (contralateral to those used for preparation of undecalcified histological sections) were measured using a digital torque gauge (BTG-E100CN, Tonichi, Tokyo, Japan), in accordance with a previous study [ 17 ]. Furthermore, using the undecalcified histological sections, the bone implant contact (BIC) ratio of each specimen was measured as the ratio of contact length of newly formed bone (total length from the top of the implant shoulder parts to the bottom parts of the first four threads).…”