Novel Development of Phosphate Treated Porous Hydroxyapatite

Doi, Katsuhiko; Abe, Yasunori; Kobatake, Reiko; Okazaki, Yoshiaki; Oki, Yoshio; Naito, Yoshihito; Prananingrum, Widyasri; Tsuga, Kazuhiro

doi:10.3390/ma10121405

Cited by 9 publications

(8 citation statements)

References 24 publications

(32 reference statements)

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“…It is well known that HA is a biomaterial relatively insoluble in vivo. By contrast, β-TCP shows good bioreabsorption in vivo [32]. With the purpose of granting a certain degree of biodegradation to the 3D structures and trying to adjust the kinetics of biodegradation to the rate of formation of new bone without abrupt deterioration of the final mechanical properties of the scaffolds, several 40 wt.% of biphasic HA/β-TCP systems were also prepared.…”

Section: Resultsmentioning

confidence: 99%

Development, Characterization and In Vitro Biological Properties of Scaffolds Fabricated From Calcium Phosphate Nanoparticles

Morejón

Delgado

Ribeiro

et al. 2019

IJMS

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Ceramic materials mimic the mineral composition of native bone and feature osteoconductive properties; they are therefore used to regenerate bone tissue. Much research focuses on increasing the porosity and pore interconnectivity of ceramic scaffolds to increase osteoconductivity, cell migration and cell-cell interaction. We aimed to fabricate biocompatible 3D-scaffolds featuring macro- and microporous calcium phosphates with high pore interconnection. Nanoparticles of hydroxyapatite (HA) and calcium deficient hydroxyapatite (CDHA) were synthesized by wet chemical precipitation. Scaffolds were produced from them by the replication polymeric foam technique. Solid content and sintering temperature were varied. Nanoparticles and scaffolds were characterized regarding morphology, chemical and mineral composition, porosity and mechanical properties. Biocompatibility, cell attachment and distribution were evaluated in vitro with human adipose mesenchymal stem cells. Scaffolds with total porosity of 71%–87%, pores in the range of 280–550 µm and connectivity density up to 43 mm−3 were obtained. Smaller pore sizes were obtained at higher sintering temperature. High solid content resulted in a decrease of total porosity but increased interconnectivity. Scaffolds 50HA/50β-TCP featured superior interconnectivity and mechanical properties. They were bioactive and biocompatible. High HA solid content (40 wt.%) in the HA pure scaffolds was negative for cell viability and proliferation, while in the 50HA/50β-TCP composite scaffolds it resulted more biocompatible.

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Section: Resultsmentioning

confidence: 99%

Development, Characterization and In Vitro Biological Properties of Scaffolds Fabricated From Calcium Phosphate Nanoparticles

Morejón

Delgado

Ribeiro

et al. 2019

IJMS

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“…Although the porous structures and rough surfaces of the scaffolds resulted in a relatively lower degree of crystallinity (DC), the DC of EDHA (20%) was still higher than that of PSHA (12%). Previous studies have shown that HA with higher DC has lower solubility ( Doi et al, 2017 ; Bertazzo et al, 2010 ; Kattimani et al, 2016 ; da Silva et al, 2020 ), indicating that the solubility of HA coated in PSHA is higher than that of EDHA in the present study. HA coated on EDHA scaffolds completely covered the scaffolds, while molten PSHA coatings were relatively smooth and evenly spread on the scaffold surface.…”

Section: Discussionmentioning

confidence: 46%

Plasma Spray vs. Electrochemical Deposition: Toward a Better Osteogenic Effect of Hydroxyapatite Coatings on 3D-Printed Titanium Scaffolds

Sun

Zhang

Luo

et al. 2021

Front. Bioeng. Biotechnol.

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Surface modification of three-dimensional (3D)-printed titanium (Ti) scaffolds with hydroxyapatite (HA) has been a research hotspot in biomedical engineering. However, unlike HA coatings on a plain surface, 3D-printed Ti scaffolds have inherent porous structures that influence the characteristics of HA coatings and osteointegration. In the present study, HA coatings were successfully fabricated on 3D-printed Ti scaffolds using plasma spray and electrochemical deposition, named plasma sprayed HA (PSHA) and electrochemically deposited HA (EDHA), respectively. Compared to EDHA scaffolds, HA coatings on PSHA scaffolds were smooth and continuous. In vitro cell studies confirmed that PSHA scaffolds have better potential to promote bone mesenchymal stem cell adhesion, proliferation, and osteogenic differentiation than EDHA scaffolds in the early and late stages. Moreover, in vivo studies showed that PSHA scaffolds were endowed with superior bone repair capacity. Although the EDHA technology is simpler and more controllable, its limitation due to the crystalline and HA structures needs to be improved in the future. Thus, we believe that plasma spray is a better choice for fabricating HA coatings on implanted scaffolds, which may become a promising method for treating bone defects.

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“…Bioceramics based on HA are biocompatible, corrosion-resistant, have low toxicity, and have good compressive strength [40]. Whereas β-TCP is bioabsorbable, and bioresorption occurs due to osteoclast activity [41]. An example of porous hydroxyapatite is shown in Figure 1 [42].…”

Section: Methodsmentioning

confidence: 99%

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

Chernobrovchenko¹,

Dyadyura²,

Balynskyi³

et al. 2021

JES

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The implantation of bone substitutes depends on the material’s osteoconductive potential and the structure’s porosity Porosity is a characteristic feature of most materials. The porosity of materials has a strong influence on some of their properties, both structural and functional. An essential requirement for bone scaffolds is porosity, which guides cells into their physical structure and supports vascularization. The macroporosity should be large enough and interdependent for bone ingrowth to occur throughout the entire volume of the implant. The pore size for cell colonization in bioceramics is approximately 100 μm. Pores larger than this value promote bone growth through the material. This pore size allows the flow of growth factors and cell adhesion and proliferation, allowing the formation of new bone and developing the capillary system associated with the ceramic implant. Porosity also affects the rate of resorption of ceramics: the larger the number of micropores, the higher the dissolution rate. The investigated properties were elastic moduli, ultimate strength, compressive strength, and average apparent density. The results obtained in this work are consistent with previous studies, proving the positive role of microporosity in osseointegration and bone formation.

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Novel Development of Phosphate Treated Porous Hydroxyapatite

Cited by 9 publications

References 24 publications

Development, Characterization and In Vitro Biological Properties of Scaffolds Fabricated From Calcium Phosphate Nanoparticles

Development, Characterization and In Vitro Biological Properties of Scaffolds Fabricated From Calcium Phosphate Nanoparticles

Plasma Spray vs. Electrochemical Deposition: Toward a Better Osteogenic Effect of Hydroxyapatite Coatings on 3D-Printed Titanium Scaffolds

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

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