The Analytical Hierarchy Process (AHP) is one of the multi-criteria methods with tools that are effective for decision-making in complementary or alternative medicine (CAM). This approach, in combination with other available methods, such as the Utrecht Method, allows medical professionals and patients themselves to take a balanced choice of special treatment and health control. This is particularly important for pregnant women who suffer from nausea and vomiting during pregnancy (NVP). The mechanisms of toxicosis occur, and the way of treatment have certain uncertainties. The decision-making process for therapeutic care must consider several factors, the determination of which is the result of collaboration between the patient and the healthcare provider. This paper presents the results of a decision-making study regarding the use of the ginger medicinal plant in helping a woman with NVP symptoms. The research was conducted using the original questionnaire according to the methodology proposed by the developers of the Utrecht Method. The chosen respondents were healthcare professionals with experience in treating NVP and pregnant women. The Analytical Hierarchy Process (AHP) capabilities in decision-making were shown in an example of analyzing the benefits, risks, and side effects of using ginger during pregnancy. The combination of two methodological approaches allowed to successfully connect the proven facts of using CAM therapy with the subjective assessment of all stakeholders. The study demonstrates that this approach successfully uses decision-making by structuring hierarchical decision elements and weighing the criteria involved in the decision-making issue. The article examines the practicality and effectiveness of using AHP when making decisions regarding the treatment and improvement of the condition of pregnant women with NVP, and summarizes the quantitative and qualitative indicators of the effectiveness of this method. The presented combination of two methodological approaches in decision-making allows for choosing an optimized medical strategy for supporting pregnant women through CAM therapy.
Regenerative biomechanics provides exciting technologies for developing functional substitutes, intending to restore and regenerate damaged tissues and organs. Scaffolds are in great demand. However, there are risks of biocompatibility when using scaffolds. Each bone substitute has its chemical composition, and other characteristics have advantages and disadvantages. Reproducibility, data sharing, privacy concerns, and patient participation in clinical trials are significant problems in modern clinical trials. In the era of the Internet, data is collected constantly. Today we need applications that ensure the privacy of users’ data. Blockchain technology helps to compensate for severe data management problems (e.g., patient recruitment, ongoing monitoring) in clinical trials (CT). The article examines the principles of blockchain operation and approaches to bone substitutes’ design. Based on this data, a blockchain model for biomaterial surgery has been created, facilitating interaction between the parties and reducing errors.
The implantation of bone substitutes depends on the material’s osteoconductive potential and the structure’s porosity Porosity is a characteristic feature of most materials. The porosity of materials has a strong influence on some of their properties, both structural and functional. An essential requirement for bone scaffolds is porosity, which guides cells into their physical structure and supports vascularization. The macroporosity should be large enough and interdependent for bone ingrowth to occur throughout the entire volume of the implant. The pore size for cell colonization in bioceramics is approximately 100 μm. Pores larger than this value promote bone growth through the material. This pore size allows the flow of growth factors and cell adhesion and proliferation, allowing the formation of new bone and developing the capillary system associated with the ceramic implant. Porosity also affects the rate of resorption of ceramics: the larger the number of micropores, the higher the dissolution rate. The investigated properties were elastic moduli, ultimate strength, compressive strength, and average apparent density. The results obtained in this work are consistent with previous studies, proving the positive role of microporosity in osseointegration and bone formation.
Due to the increase in diseases in the musculoskeletal system, regenerative medicine is now developing various bone substitutes. Not all scaffolds, due to their shortcomings, are applied for every application. Patients should be provided with basic product information and other warnings about health risks or measures to be taken. From the establishment of the purpose of the biomaterial to apply, several stages of the life cycle can pass. To ensure the biocompatibility of medical devices, there is a legislative framework and standards. They cover the full cycle from testing to market authorization, surveillance, and recall (ISO 15225:2010, ISO/IEC 33001:2015). We have developed the life cycle of bone substitutes and can offer an approach to evaluate operations based on the requirements of the ISO/IEC 33001:2015 series.
It has been proven that the main factor in the uncertainty of laboratory results is biological variation, that is, a change in the composition of human biomaterials, reflecting the course of life processes in the body and is characterized by a combination of the constancy of the internal environment and dynamic fluctuations around the homeostasis point. The paper offers objectively substantiated recommendations for the accuracy of laboratory tests, established maximum allowable values of analytical errors of quantitative research methods (measurements) of physical quantities (composition and properties of components of biological materials, analytes) in samples of biological materials. The interpretation of LOD and LOQ for detecting the concentration of leaching micro-impurities in the bioliquid. The identified patterns indicate that the elements of microimpurities have different dissolution rates. The ratio of hydroxyapatite/tricalcium phosphate affects the dissolution rate of the material: the higher the content of β-tricalcium phosphate, the higher the dissolution rate. The results of the research allow establishing recommendations for reducing inaccuracies in determining the composition of bone substitutes based on hydroxyapatite/β-tricalcium phosphate, which is associated with manifestations of biological variation, reflecting the body’s response to various environmental factors and subject to statistical laws.
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