Orange juice decreases low-density lipoprotein cholesterol in hypercholesterolemic subjects and improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemic subjects

Abstract

Orange juice (OJ) is regularly consumed worldwide, but its effects on plasma lipids have rarely been explored. This study hypothesized that consumption of OJ concentrate would improve lipid levels and lipid metabolism, which are important in high-density lipoprotein (HDL) function in normolipidemic (NC) and hypercholesterolemic (HCH) subjects. Fourteen HCH and 31 NC adults consumed 750 mL/day OJ concentrate (1:6 OJ/water) for 60 days. Eight control subjects did not consume OJ for 60 days. Plasma was collected before and on the last day for biochemical analysis and an in vitro assay of transfers of radioactively labeled free-cholesterol, cholesteryl esters, phospholipids, and triglycerides from lipoprotein-like nanoemulsions to HDL. Orange juice consumption decreased low-density lipoprotein cholesterol (160 ± 17 to 141 ± 26 mg/dL, P < .01) in the HCH group but not in the NC group. HDL-cholesterol and triglycerides remained unchanged in both groups. Free-cholesterol transfer to HDL increased (HCH: 4.4 ± 2 to 5.6 ± 1%, NC: 3.2 ± 2 to 6.2 ± 1%, P< .05) whereas triglyceride (HCH 4.9 ± 1 to 3.1 ± 1%, NC 4.4 ± 1 to 3.4 ± 1%, P< .05) and phospholipid (HCH 21.6 ± 2 to 18.6 ± 3%, NC 20.2 ± 2 to 18.4 ± 2%, P < .05) transfers decreased in both groups. Cholesteryl-ester transfer decreased only in HCH (3.6 ± 1 to 3.1 ± 1%, P < .05), but not in NC. In control subjects, plasma lipids and transfers were unaltered for 60 days. Thus, by decreasing atherogenic low-density lipoprotein cholesterol in HCH and increasing HDL ability to take up free cholesterol in HCH and NC, OJ may be beneficial to both groups as free-cholesterol transfer to HDL is crucial for cholesterol esterification and reverse cholesterol transport.

PERBAIKAN PROFIL LIPID PADA PEREMPUAN DEWASA KELEBIHAN BERAT BADAN SETELAH INTERVENSI SARI JERUK KALAMANSI (Citrus microcarpa)

“…Namun hasil yang berbeda ditunjukkan pada penelitian Cesar et al (2010), dimana penurunan yang signifikan hanya terdapat pada nilai ∆ LDL yakni -26 mg/dl (p<0,01) pada subjek dewasa yang hiperkolesterolemia. Nilai HDL dan TG tidak menunjukkan adanya perbedaan yang signifikan pada kedua perlakuan.…”

“…Nilai HDL dan TG tidak menunjukkan adanya perbedaan yang signifikan pada kedua perlakuan. Cesar et al (2010) memberikan 750 ml (1:6 jus jeruk (OJ)/ air) dengan kandungan hesperidin 42 mg, naringin 12 mg/107,14 ml OJ dan vitamin C 258 mg/750 ml OJ. Sama halnya dengan penelitian Demonty et al (2010) bahwa flavonoid yakni hesperidin (80%/kapsul) dan naringin (93%/kapsul) tidak signifikan menurunkan TC, LDL dan juga tidak signifikan meningkatkan HDL-c pada pria dan wanita yang hiperkolesterol (moderat).…”

Fruit Juice, Organic Anion Transporting Polypeptides, and Drug Interactions in Psychiatry

“…4 Orange juice is similarly associated with health benefits. For example, orange juice reduces low-density lipoprotein cholesterol levels 5 and may have favorable effects on bone health. 6 Anti-inflammatory, antioxidant, cytoprotective, antigenotoxic, and antitumoral constituents have been identified in orange juice.…”

Portulaca oleracea extract increases lecithin:cholesterol acyltransferase and paraoxonase 1 activities and enhances reverse cholesterol transport in streptozotocin-induced diabetic rat

“…[36] Increased HDL-C level can also facilitate the transport of cholesterol from tissues to liver. [37] The possible mechanism of this activity may result from the enhancement of lecithin:cholesteryl acyltransferase (LCAT). [38] In Portulaca oleracea treated compared with untreated diabetic group, LCAT activity was increased and the concentrations of plasma apo A-I tended to be higher but not significantly.…”