Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life

Militaru, Constantin; Donoiu, I; Craciun, Alina; Scorei, Iulia Daria; Bulearca, Anca; Scorei, Ion Romulus

doi:10.1016/j.nut.2012.07.006

Cited by 144 publications

(112 citation statements)

References 31 publications

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“…In this context, it has been reported that resveratrol administration in patients with stable coronary artery disease (8-10 mg/kg for 3 and 12 months), improved LV diastolic pressure and circulatory proinflammatory markers respectively [26,27]. Also, Militaru et al [28] have shown that 60 days' treatment with resveratrol decreased inflammatory markers in patients with stable angina pectoris.…”

Section: Resveratrol and Cardioprotectionmentioning

confidence: 99%

Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

2014

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8-isoprostane, 6.03 ± 0.87 vs. 8.49 ± 0.52 µmol, p < 0.05 for nitrite/nitrate, and 0.44 ± 0.03 vs. 0.59 ± 0.04, p < 0.05 for oxidized/reduced glutathione ratio), nuclear factor kappa B activity (0.37 ± 0.09 vs. 0.60 ± 0.11, p < 0.05) and apoptosis rate (0.98 ± 0.28 vs. 1.63 ± 0.16, p < 0.05). Moreover, it improved left ventricular developed pressure (72.46 ± 8.16 vs. 52.01 ± 11.32 mm Hg, p < 0.05) and coronary flow (14.08 ± 1.09 vs. 11.75 ± 1.43 mL/ /min × g, p < 0.05). Conclusions: These beneficial cardioprotective observations suggest that treatment with resveratrol can potentially delay or attenuate the progression of diabetes-related cardiac complications. (Cardiol J 2014; 21, 1: 39-46)

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Section: Resveratrol and Cardioprotectionmentioning

confidence: 99%

Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

2014

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“…6 Regarding the relationship between boron intake and the prevalence inflammatory joint diseases, many researchers have discovered that abundant intake of dietary boron can confer strong protection against the development of these diseases. 7,8 According to the outcome of many experimental studies, the suggested hypothesis for this effect of boron includes reduction in the risk of inflammatory disease by downregulating enzymes of the inflammatory response, in addition to well-recognized immunomodulatory effects in the arthritic rat models, [9][10][11] although the exact dose-response relationship of such effect is not well-characterized in standardized animal models of inflammation. The present study was designed to evaluate the dose-response relationship of the orally administered boron, alone or as an adjuvant with dexamethasone in animal models of chronic and granulomatous inflammations.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of boron alone or as adjuvant with dexamethasone in animal models of chronic and granulomatous inflammation

Ameen

Hussain

Ahmed

et al. 2015

Int J Basic Clin Pharmacol

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“…Therefore, substances with the possible anti-thrombotic and anti-sclerotic capacity, such as resveratrol, may assume an important role in the family therapy of these diseases. However, there are records in the literature of randomized clinical trials, in which the participants at cardiovascular risk, with the use of resveratrol either obtained improvement in clinical outcomes, or did not, such as longer survival, improvement in quality of life or reduction of infarctions 13 .…”

Section: Effects Of Interventionsmentioning

confidence: 99%

“…Therefore, one perceives that the possible effects of resveratrol are closely connected to CVD, since endothelial dysfunction and accumulation of LDL are the first steps towards the formation of atheromatous plaque 10,11,12 . As resveratrol has antioxidant, anti-thrombotic and anti-atherosclerotic properties, it may represent a substance of great potential use in clinical practice, with a view to better control of CVD 13 . Therefore, the aim of the present study was to evaluate the effect of the use of resveratrol on the prevention of cardiovascular events, endothelial function and the inflammatory response in human beings.…”

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confidence: 99%

Use of Resveratrol in Cardiovascular Diseases Prevention: A Systematic Review

Góes

Fraga

Ladeia

2017

BJMHH

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| Resveratrol, a polyphenolic compound found in blackberry and red wine, has properties that prevent the development of atherosclerosis, and therefore, cardiovascular disease. The aim of this study was, through a systematic review, to assess whether resveratrol reduces the incidence of cardiovascular events and improves inflammation and endothelial dysfunction in individuals at risk. Searches were conducted in databases such as LILACS, PubMed,SCIELO and selected randomized controlled trials in humans, including the use of resveratrol in the prevention of cardiovascular events or in the improvement of inflammation and endothelial function. The final sample consisted of 10 items. Of the four studies that analyzed the flow-mediated dilatation of the brachial artery, all showed significant improvement in endothelial function after the use of resveratrol, compared with placebo. In the 7 studies that evaluated subclinical inflammation, there were differences, 3 studies showed significant decreases in the values of TNF-α, 2 showed significant changes in plasma levels of C-reactive protein and interleukin 6 (IL-6), while 1 didn't showed changes in TNF-α and IL-6. In conclusion, resveratrol is capable of improving endothelial function when compared with placebo. However, it was not possible to infer an improvement or not in the parameters concerning endothelial inflammation, since the data extracted from the studies were insufficient. Moreover, it was not possible to evaluate the use of resveratrol in the improvement of survival, infarction or reduction in mortality, since there were no records in the literature of randomized controlled trials that analyzed the effect of resveratrol use on clinical outcomes in humans.

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Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life

Abstract: The results indicate that the combination of resveratrol and calcium fructoborate has beneficial effects in patients with angina

Cited by 144 publications

References 31 publications

Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

Anti-inflammatory effects of boron alone or as adjuvant with dexamethasone in animal models of chronic and granulomatous inflammation

Use of Resveratrol in Cardiovascular Diseases Prevention: A Systematic Review

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