Anti-inflammatory effects of boron alone or as adjuvant with dexamethasone in animal models of chronic and granulomatous inflammation

Ameen, Hanaw N. Mohammed; Hussain, Saad Abdulrahman; Ahmed, Zheen Aorahman; Aziz, Tavga Ahmed

doi:10.18203/2319-2003.ijbcp20150376

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…This can be attributed to the differences in baseline values among groups and the multifactorial etiology of CRP elevation. Although the current results represents the first finding regarding the influence of boron on CRP levels in patients with active RA maintained of biological therapy, they seem to be comparable with many previous reports that utilize other disease models [ 9 , 38 ]. TNF-α is important mediator of inflammation and tissue damage in active RA [ 39 ].…”

Section: Discussionsupporting

confidence: 90%

“…These results were in tune with those reported previously regarding the use of boron as adjuvant in patients with knee OA, where inclusion of boron in the currently used treatment modulates the symptoms of arthritis and joint degeneration and improves the clinical scores [ 23 , 24 ]. The anti-inflammatory activity of boron was reported in animal models of inflammation [ 8 , 9 ]; however, no previous data declared its role as adjuvant with etanercept to improve the clinical outcome of RA treatment. The reported improvement may be due to long-term inhibition of the pro-inflammatory mediators, which may indirectly lead to reduction in the followed clinical scores.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, the use of supplements from natural sources to attenuate the inflammation-induced oxidative damage, such as phytochemicals and trace elements, may provide further therapeutic benefits to the currently used antirheumatic agents [ 6 , 7 ]. Moreover, many of these natural supplements have the ability to potentially interfere with the inflammatory cascades, probably through attenuating the release of pro-inflammatory markers such as tumor necrosis factor-α (TNF-α) and other cytokines, which are clearly in many human and experimental animal studies [ 8 , 9 ]. The trace element boron is a necessary micronutrient for the proliferation of many biological systems [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study

Hussain

Abood

Gorial

2017

J Intercult Ethnopharmacol

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Objective:This study was designed to evaluate the effects calcium fructoborate (CFB) and sodium tetraborate (NTB) as supplements in Iraqi patients with active rheumatoid arthritis (RA) maintained on etanercept.Materials and Methods:A double-blind randomized placebo-controlled clinical trial with 60 days treatment period was carried out at Baghdad Teaching Hospital, Medical city, Baghdad, Iraq. Eighty RA patients were randomized into three groups to receive either 220 mg/day CFB, 55 mg/day NTB in capsule dosage form (equivalent to 6 mg elemental Boron), or placebo formula once daily. Only 72 patients completed the study. All patients were clinically evaluated utilizing DAS28-erythrocyte sedimentation rate (ESR), simple disease activity index-C-reactive protein (CRP), and clinical disease activity index scores at baseline, and at the end of the study. Venous blood was obtained at baseline and after 60 days, and utilized for the measurement of ESR, hemoglobin, in addition to evaluation of high-sensitivity CRP (hsCRP), tumor necrosis factor-α (TNF-α), interleukin-1α (IL-1α) and IL-6.Results:After 60 days, both types of boron significantly improve the clinical scores, in association with significant decrease in the serum levels of ESR, hsCRP, IL-1α, IL-6, and TNF-α with remarkable superiority for calcium fructoborate (CFB) over sodium tetraborate (NTB), compared to baseline and placebo-treated group.Conclusion:The use of boron, as adjuvant with etanercept, has potentiated therapeutic outcomes in RA patients, and may be a new strategy to improve treatment, and avoid the problems associated with biologics utilized in RA treatment.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study

Hussain

Abood

Gorial

2017

J Intercult Ethnopharmacol

Self Cite

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“…These derivatives at 10 -6 M are effective inhibitors of hydrolytic lysosomal and proteolytic enzymes in mouse macrophages, human leukocytes, and Be Sal osteofibrolytic cells, and in the same cell lines this compound blocks cyclooxygenase activity with an LD 50 value of 10 -6 M (48). Tetrahydroborates have also been shown to reduce inflammation in a rat model of chronic and granulomatous inflammation (49). These findings indicate that TBB derivatives have anti-inflammatory activity.…”

Section: Figure 5 Inhibitory Effects Of Tri-n-butyl Borane (Tbb) On mentioning

confidence: 87%

Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species

Kawata

Murakami

Suzuki

et al. 2018

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“…Borate ion also exhibits anti-inflammatory effects, similar to strontium ion. Ameen et al reported that oral administration of borate dose-dependently decreases experimental chronic inflammation in rat 31) . They speculated that boron decreases the production of proinflammatory cytokines by monocytes/macrophages.…”

Section: Discussionmentioning

confidence: 99%

Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler

et al. 2020

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Surface pre-reacted glass-ionomer (S-PRG) filler releases several ions, such as fluoride, borate and strontium ions, to exert bioactive effects. We fabricated an endodontic root canal sealer containing S-PRG fillers (S-PRG sealer) and then evaluated the antibacterial and anti-inflammatory properties of S-PRG sealer compared with sealer containing conventional silica fillers (silica sealer). Antibacterial tests showed that S-PRG sealer significantly reduced the turbidity of Enterococcus faecalis compared with silica sealer. Implantation of S-PRG or silica sealer blocks in rat subcutaneous tissue showed that S-PRG sealer decreased the proinflammatory response compared with silica sealer at 10 days post-implantation. In addition, immunostaining revealed that infiltration of CD68and peroxidase-positive cells around the S-PRG sealer was significantly lower than that in silica sealer. Therefore, it was suggested that S-PRG sealer exhibits antibacterial and anti-inflammatory effects.

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Anti-inflammatory effects of boron alone or as adjuvant with dexamethasone in animal models of chronic and granulomatous inflammation

Cited by 8 publications

References 20 publications

The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study

The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study

Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species

Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler

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