Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler

Miyaji, Hirofumi; Mayumi, Kayoko; Miyata, Sumiko; Nishida, Erika; Shitomi, Kanako; Hamamoto, Asako; Tanaka, Saori; Akasaka, Tsukasa

doi:10.4012/dmj.2019-029

Cited by 20 publications

(22 citation statements)

References 33 publications

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“…2016, Miyaji et al . 2020). Bacteria P. acnes, A. israelii , and fungus Candida albicans are frequently isolated and characterized from the root canal in apical periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence in a previous rat study demonstrated that the anti‐inflammatory effect of S‐PRG sealer implanted into subcutaneous tissue involved a decrease in CD68 cell infiltration (Miyaji et al . 2020). In the current study, the CD68 (ED1) reduction in macrophages in response to S‐PRG or Ca(OH) 2 indicated that the bacterial stimuli subsided and the inflammation resolved in the periapical area, which is of critical importance in the regulation of periapical tissue remodelling and the relief of clinical symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…2016, Miyaji et al . 2020). However, the impact of S‐PRG products on apical periodontitis is yet to be explored.…”

Section: Introductionmentioning

confidence: 99%

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The potential of a surface pre‐reacted glass root canal dressing for treating apical periodontitis in rats

et al. 2020

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AimTo evaluate the efficacy of a prototype root canal dressing containing surface pre‐reacted glass–ionomer (S‐PRG) fillers on repairing induced periapical lesions in a rat model. Calcium hydroxide [Ca(OH)2] was applied as a comparison in the healing process.MethodologyThe pulp chambers of the maxillary first molars in 64 male Wistar rats aged 16 weeks were opened to induce periapical lesions. After 28 days, the mesial canal of each tooth was prepared, irrigated with 2.5% sodium hypochlorite only (control group: irrigation) or followed by the respective dressing [Ca(OH)2 group, irrigation + Ca(OH)2; S‐PRG group, irrigation + S‐PRG] and restored with composite resin for 3 or 7 days (10/group). Four rats with healthy molars were used as blank controls. Descriptive analysis of the periapical radiographs, haematoxylin and eosin staining and immunohistochemical observation was performed 3 and 7 days after treatment. The periapical grey value, CD68 macrophages and osteoclasts (cathepsin‐K) were quantified and statistically analysed with Tukey’s honest significant difference test. A significant difference was achieved when P values were <0.05.ResultsS‐PRG and Ca(OH)2 dressings were associated with increased periapical grey values and inhibited osteoclast activity at 3 and 7 days; a significant difference in radiographic results and the number of osteoclasts was obtained at 3 and 7 days compared with the control group (P < 0.05). Reparative tissue was observed histologically in the space of the periapical resorbed necrotic area after S‐PRG and Ca(OH)2 treatment for 3 and 7 days. The number of macrophages was significantly decreased at 3 and 7 days in the S‐PRG and Ca(OH)2 specimens when compared with the controls (P < 0.05).ConclusionsIn a rat experimental model, the S‐PRG root canal dressing was comparable to Ca(OH)2 in promoting the healing of experimentally induced periapical lesions. S‐PRG paste has the potential to be used as an alternative intracanal dressing in teeth with apical periodontitis.

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“…2016, Miyaji et al . 2020). Bacteria P. acnes, A. israelii , and fungus Candida albicans are frequently isolated and characterized from the root canal in apical periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The potential of a surface pre‐reacted glass root canal dressing for treating apical periodontitis in rats

et al. 2020

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confidence: 89%

“…In addition, an endodontic root canal sealer containing an S-PRG filler (i.e., S-PRG sealer) exhibited good antibacterial and anti-inflammatory properties. Finally, the implantation of S-PRG sealer into the subcutaneous tissues of rats noticeably decreased their inflammatory responses [17].The primary objective of this study was to examine the inhibitory effects of GIC restoratives and coating materials containing S-PRG fillers on enamel demineralization to evaluate their anticaries properties. The null hypothesis was that the GIC and S-PRG fillers would not inhibit the demineralization of bovine enamel specimens incubated in a lactic acid solution with pH = 4.0.Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 8 April 2020…”

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Protective Effects of GIC and S-PRG Filler Restoratives on Demineralization of Bovine Enamel in Lactic Acid Solution

Kaga¹,

Nagano-Takebe²,

Noji³

et al. 2020

Preprint

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We investigated the protective effects of glass ionomer cement (GIC) and surface pre-reacted glass ionomer (S-PRG) fillers used as dental restorative materials on the demineralization of bovine enamel during the incubation in a lactic acid solution with pH = 4.0 conducted for 6 d at a temperature of 37 °C. Scanning electron microscopy images of the specimen surfaces from the group containing only enamel blocks revealed the presence of apparent enamel prism peripheries after 6 d of treatment. The mineral was etched from the enamel surface, and a large number of Ca ions were detected in solution. In contrast, the enamel blocks incubated together with discs of GIC or S-PRG fillers did not exhibit demineralized surfaces, owing to the neutralization of the acid solution by the fillers within the first 3 h of the incubation process. The observed pH neutralization effect was attributed to the release of different ions from the fillers and could be utilized for suppressing the progression of caries.bioactive materials before employing a restorative approach that requires the removal of tooth tissue [7].The main purpose of developing bioactive and antibacterial materials is to prevent damage of hard tissues. Glass ionomer cements (GICs) have been widely used for the conservative treatment of enamel and dentin because of their beneficial properties such as strong chemical bonding to the tooth substrate and release of fluoride ions [8]. Furthermore, while conventional GICs release the ions of their constituent materials, light-cured GICs produce significant amounts of Al, Ca, F, Na, P, Si, and Sr ions in neutral or acidic solutions over time and can effectively neutralize lactic acid solutions [9,10] to prevent demineralization of the areas adjacent to the tooth surface and suppress the formation of initial caries.A few years ago, a new zinc-containing GIC characterized by a higher flexural strength as compared with those of conventional GICs was developed [11]. However, after two years of clinical trials, it was found to be unsuitable for cavity preparation [12]. Meanwhile, surface pre-reacted glass ionomer (S-PRG) fillers were introduced as bioactive materials that were able to retain their basic properties by forming a stable glass ionomer phase on the treated surface through the acid-base reaction between the fluoro-boro-alumino-silicate glass and polyacrylic acid [13]. These fillers represent a novel class of particle materials that can be incorporated into resin matrices to induce the release of different types of ions and thus produce a strong bioactive effect. The results of in-vitro studies demonstrated the effectiveness of such materials in inhibiting the demineralization of the tooth substrate [14][15][16] and preventing the initiation of caries. In addition, an endodontic root canal sealer containing an S-PRG filler (i.e., S-PRG sealer) exhibited good antibacterial and anti-inflammatory properties. Finally, the implantation of S-PRG sealer into the subcutaneous tissues of rats noticeably decreased their inflamma...

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Impact of Nanotechnology on the Realm of Stem Cells and Regenerative Medicine

2022

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The intersection of very different, yet complementary fields, stem cells and nanotechnology, has led to the opening of new horizons in the area of research, giving new hopes, better strategies, and a boost to regenerative medicine, nanotherapeutics, and tissue engineering. Harnessing the stem cell's ability to self‐renew and differentiate into specific types of functional cells and the unique physico‐chemical properties of the nanomaterials, researchers have optimized the interactions of these with the biological milieu to overcome the hurdles of conventional cell‐based therapies. Here, we highlight and outline various types of nanomaterials and their well‐established significance in redefining the future of human medicine through influencing stem cell research targeting illness of important human organs.

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Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler

Cited by 20 publications

References 33 publications

The potential of a surface pre‐reacted glass root canal dressing for treating apical periodontitis in rats

The potential of a surface pre‐reacted glass root canal dressing for treating apical periodontitis in rats

Protective Effects of GIC and S-PRG Filler Restoratives on Demineralization of Bovine Enamel in Lactic Acid Solution

Impact of Nanotechnology on the Realm of Stem Cells and Regenerative Medicine

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