Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritis

Abstract

Introduction Phosphatidylcholine and phosphatidylcholinederived metabolites exhibit anti-inflammatory properties in various stress conditions. We hypothesized that dietary phosphatidylcholine may potentially function as an antiinflammatory substance and may decrease inflammatory activation in a chronic murine model of rheumatoid arthritis (collagen-induced arthritis).

Relevance of dietary glycerophospholipids and sphingolipids to human health

“…The use of PLs (especially PC) reduced rheumatoid arthritis [134,135], pleurisy and leukocyte adhesion [134]. Treede et al [136] and Taylor et al [36] explained the anti-inflammatory effects of PC with inhibition of TNF alpha and TNF beta , whose reduced levels might also play positive roles on weight control.…”

Anti-inflammatory, antinociceptive and anti-angiogenic activities of a phospholipid mixture purified from porcine lung tissues

“…(9) Oral pretreatment of PC diminishes the inflammation-related pain, angiogenesis and structural damages to the joints in a chronic murine model for rheumatoid arthritis, which are accompanied by the inhibition of the inducible nitric oxide synthase (iNOS) expression and the down-regulation of the leukocyte activation. (10) These results suggest that orally administered PC may be useful as a preventive tool to improve the unfavorable conditions involved in rheumatoid arthritisinduced joint damage. (10) Retarded or elongated release of orally administered PC was also proven to be beneficial in lessening the activity of inflammation complicated with ulcerative colitis, a chronic inflammatory disorder of the colonic mucosa.…”

“…(10) These results suggest that orally administered PC may be useful as a preventive tool to improve the unfavorable conditions involved in rheumatoid arthritisinduced joint damage. (10) Retarded or elongated release of orally administered PC was also proven to be beneficial in lessening the activity of inflammation complicated with ulcerative colitis, a chronic inflammatory disorder of the colonic mucosa. (11) This finding might be consistent with the fact that the mucus obtained from the patients with ulcerative colitis contains a low level of PC compared to one obtained from healthy subjects in which the main phospholipid species in mucus are PC and lysoPC.…”

Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease

“…AEA may be important in the anti-inflammatory response observed upon FAAH inhibition; suggesting that as blockade of FAAH increased the anti-inflammatory response and analgesic effects, it could be useful in RA treatment [94]. Another study from Eros et al examined how dietary phosphatidylcholine (PC) can affect a collagen-induced arthritis (CIA) murine model of RA [96]. Eros et al found that when PC, a precursor of AEA, was given prior to onset of clinical signs of inflammation, CIA-induced pain were abrogated, and that damage to the synovium, cartilage, and bone was decreased when compared to disease control and treatment after the onset of symptoms [96].…”

“…Another study from Eros et al examined how dietary phosphatidylcholine (PC) can affect a collagen-induced arthritis (CIA) murine model of RA [96]. Eros et al found that when PC, a precursor of AEA, was given prior to onset of clinical signs of inflammation, CIA-induced pain were abrogated, and that damage to the synovium, cartilage, and bone was decreased when compared to disease control and treatment after the onset of symptoms [96]. Upon further examination, these data suggested that AEA may cause reductions in pain and inflammation in RA models either through exogenous additions or via inhibition of endogenous degradation.…”