Relevance of dietary glycerophospholipids and sphingolipids to human health

Castro-Gómez, Pilar; García-Serrano, Alba M.; Visioli, Francesco; Fontecha, Javier

doi:10.1016/j.plefa.2015.07.004

Cited by 133 publications

(94 citation statements)

References 166 publications

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“…Nowadays, milk lipid analysis is an important area of research due to the presence of bioactive FAs, such as short- and branched-chain FA and conjugated linoleic acid, in addition to other minor components, such as the PLs (phospho- and sphingolipids) [2]. Regarding the PL of the MFGM, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), and sphingomyelin (SM) are the major components and incite great interest due to their potential positive effects on human health; most research is centered on some cancers and neurological pathologies [3]. In spite of the fact that the concentration of these molecules in comparison to total milk fat is low (<1% of total fat) [4], they are of great importance because the structure acquired from mammary cellular membranes provides to MFGM an exclusive PL composition in comparison with commercial PL sources [5].…”

Section: Introductionmentioning

confidence: 99%

In-Depth Lipidomic Analysis of Molecular Species of Triacylglycerides, Diacylglycerides, Glycerophospholipids, and Sphingolipids of Buttermilk by GC-MS/FID, HPLC-ELSD, and UPLC-QToF-MS

Castro-Gómez

Montero

Fontecha

2017

IJMS

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Buttermilk, a byproduct of butter manufacturing, has gained considerable attention due to its high concentration of polar lipids as phospho- and sphingolipids from the milk fat globule membrane (MFGM). These polar lipids (PLs) are essential components of all cellular membranes and exert a variety of indispensable metabolic, neurological, and intracellular signaling processes. Despite its importance, there are few research studies that report a comprehensive characterization of the lipid molecular species of MFGM that could contribute to a better understanding of their putative healthful activities. In this study, procedures such as pressurized liquid extraction of polar and nonpolar lipids and their fractionation by flash chromatography have been carried out. The obtained fractions were submitted to an exhaustive characterization from a lipidomic point of view. The characterization includes new data about the identification and quantification of triacylglycerides (TAG), diacylglycerides (DAG), and phospho- and sphingolipids using different chromatographic techniques. The fatty acid profile was comparable to that of the milk fat but with a highly diverse composition of fatty acids. Molecular species have also been determined by using ultra-high performance liquid chromatography/quadruple-time-of-flight mass spectrometry (UPLC/QToF-MS). The TAG (16:0/16:0/6:0) and TAG (16:0/16:0/8:0) were the predominant saturated TAG species and TAG (14:0/18:1/16:0) and TAG (16:0/16:0/18:1) presented the highest content of monounsaturated TAG species. Furthermore; over 30 molecular species of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylinositol (PI) could be identified within PL, with PC (16:0/18:1) being the most abundant species. Whereas C16:0 was found to be the preferred FA in TAGs, it was C18:1 in PLs. Several ganglioside species have also been characterized with d18:1 ceramide moiety and secondary acyl chains ranging from C20:0 to C26:1. This approach could broaden the applications of high-resolution mass spectrometry for a better understanding of the role of MFGM and its functionality.

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Section: Introductionmentioning

confidence: 99%

In-Depth Lipidomic Analysis of Molecular Species of Triacylglycerides, Diacylglycerides, Glycerophospholipids, and Sphingolipids of Buttermilk by GC-MS/FID, HPLC-ELSD, and UPLC-QToF-MS

Castro-Gómez

Montero

Fontecha

2017

IJMS

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“…In contrast, participants that received the high dose of PI also showed a significant decrease in plasma TAG levels. Currently, global consumption of lipids including PL is decreasing due to the widespread use of low fat products (5). Taken together, we conclude that the current consumption of PL is insufficient to exert any beneficial effects associated with dietary PL.…”

Section: Discussionmentioning

confidence: 67%

“…PL intake is estimated to be 2-4 g per day (1-3), which amounts to approximately 10% of total dietary lipids (4,5). Growing evidence indicates that dietary PLs have beneficial effects compared with dietary triacylglycerols (TAGs), including prevention of dyslipidemia (6)(7)(8)(9) and fatty liver disease (10)(11)(12)(13).…”

mentioning

confidence: 99%

Quantities of Phospholipid Molecular Classes in Japanese Meals and Prediction of Their Sources by Multiple Regression Analysis

Shirouchi

Yamanaka

Tanaka

et al. 2018

J Nutr Sci Vitaminol

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“…Dans ce contexte, les lipides polaires du lait suscitent un intérêt grandissant. Plusieurs études soulignent que ces derniers pourraient exercer des effets bénéfiques dans diverses pathologies dont le cancer colorectal, les désordres neurologiques et les maladies cardiométaboliques (Cohn et al, 2009 ;Castro-Gomez et al, 2015 ;Kullenberg et al, 2012). Nous avons donc cherché à identifier, chez la souris, l'impact de l'utilisation de lipides polaires laitiers en comparaison avec des lipides polaires de soja (lécithine de soja) sur la digestion, l'absorption et le métabolisme post-prandial des lipides lorsqu'ils sont utilisés comme émulsifiant, et à plus long terme incorporés dans un régime hyperlipidique sur le métabolisme lipidique, l'adiposité et l'inflammation du tissu adipeux (Fig.…”

Section: Impact Métabolique De L'absorption Des Lipides Et Des Endotounclassified

Impacts métaboliques et inflammatoires des matières grasses émulsionnées

Michalski

Vors

Lecomte

et al. 2017

Cahiers de Nutrition et de Diététique

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Reçu le 31 janvier 2017 -Accepté le 2 mars 2017Résumé -Les effets des lipides sur la santé doivent aujourd'hui être étudiés par des approches allant au-delà de leur densité énergétique et de leur profil en acides gras. En effet, ces acides gras sont les briques élémentaires de différentes molécules lipidiques telles que les triacylglycérols et les phospholipides, elles-mêmes organisées sous forme de structures supramoléculaires variées comme les gouttelettes d'émulsion, et pouvant être intégrées dans différentes matrices alimentaires. Ce court article résume nos récents travaux sur l'impact de l'état émulsionné de la matière grasse sur le métabolisme post-prandial des lipides et la b-oxydation des acides gras ingérés chez l'homme mince ou obèse, ouvrant la voie au concept de « lipides rapides versus lipides lents ». Nous présentons comment la cinétique post-prandiale d'absorption des lipides peut aussi contribuer à moduler l'endotoxémie métabolique, provenant en partie d'interactions entre les lipides alimentaires et le microbiote intestinal et pouvant contribuer à l'inflammation métabolique chez l'obèse. Enfin, nous mettons en exergue l'impact pro-ou anti-inflammatoire chez la souris d'agents tensioactifs utilisés en formulation alimentaire pour stabiliser les émulsions, notamment les phospholipides d'origine végétale ou laitière, ainsi que de différents vecteurs moléculaires d'acides gras poly-insaturés n-3 à longue chaîne. Le lecteur pourra se référer à nos autres publications et revues récentes pour un approfondissement des concepts présentés.Mots clés : nutrition / matière grasse / huile / émulsifiant / inflammation / oxydation / phospholipide Abstract -Metabolic and inflammatory impacts of emulsified fat. The health effects of lipids must now be explored beyond their energy content and fatty acid profile. Indeed, fatty acids as unit elements of different molecules such as triacylglycerols and phospholipids are being organized in various supramolecular structures such as emulsion droplets, and incorporated in complex food matrixes. This short article reviews our recent studies on the impact of fat emulsified structure on postprandial lipid metabolism and fatty acid beta-oxidation in normal-weight and obese humans, leading to the concept of "fast versus slow lipids". We also show how the postprandial kinetics of lipid absorption can contribute to modulate metabolic endotoxemia, partly arising from interactions between dietary lipids and gut microbiota, and able to contribute to metabolic inflammation in obesity. Finally, we highlight the pro-or antiinflammatory impact in mice of surface active agents used in food formulation to stabilize emulsions, notably phospholipids of vegetal or dairy origin, and different molecular carriers of long-chain n-3 polyunsaturated fatty acids. The interested reader will refer to our other recent publications and reviews on these topics for a deeper insight into presented concepts.

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Relevance of dietary glycerophospholipids and sphingolipids to human health

Cited by 133 publications

References 166 publications

In-Depth Lipidomic Analysis of Molecular Species of Triacylglycerides, Diacylglycerides, Glycerophospholipids, and Sphingolipids of Buttermilk by GC-MS/FID, HPLC-ELSD, and UPLC-QToF-MS

In-Depth Lipidomic Analysis of Molecular Species of Triacylglycerides, Diacylglycerides, Glycerophospholipids, and Sphingolipids of Buttermilk by GC-MS/FID, HPLC-ELSD, and UPLC-QToF-MS

Quantities of Phospholipid Molecular Classes in Japanese Meals and Prediction of Their Sources by Multiple Regression Analysis

Impacts métaboliques et inflammatoires des matières grasses émulsionnées

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