Impacts métaboliques et inflammatoires des matières grasses émulsionnées

Michalski, Marie‐Caroline; Vors, Cécile; Lecomte, Manon; Laugerette, Fabienne

doi:10.1016/j.cnd.2017.04.003

Cited by 1 publication

(2 citation statements)

References 67 publications

(41 reference statements)

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“…4 Lipid emulsifiers and their impact on gut physiology 4.1 Synthetic and semi-synthetic emulsifiers Fats and oils are in the emulsified state in many food products. As previously reported and reviewed, emulsification per se can result in enhanced intestinal lipid absorption and metabolic transformations in both preclinical and clinical models (Couëdelo et al, 2017;Michalski et al, 2017) and can also modulate the postprandial metabolic handling of LPS in obese men (Vors et al, 2017). Importantly, emulsification involves the addition of emulsifiers and stabilizers in the food matrix to ensure both product stability and mouthfeel.…”

Section: Dietary Fat and Intestinal Crosstalk Between Bile Acids And Gut Microbiotamentioning

confidence: 98%

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Metabolic impact of dietary lipids: towards a role of unabsorbed lipid residues?

Michalski

Barz

Vors

2021

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The metabolic impact of dietary lipids needs to be considered beyond the fatty acid profile and energetic value of such lipids. Fatty acids are the building blocks of the different lipid molecules, including triacylglycerols and phospholipids, which are organized within various supramolecular structures such as emulsion droplets. These structures can also be naturally present or incorporated a posteriori in different food matrices. Gut health including its barrier function and microbiota is now recognized as a major player in cardiometabolic health. Even if more than 95% of dietary lipids are absorbed by the intestine to reach the bloodstream within the chylomicrons, a small proportion that is not absorbed is however able to interact with the microbiota and the cells of the distal intestine. The present non-exhaustive review will summarize briefly recent work on the impact of dietary lipids on absorption and their metabolic fate in the intestine, in particular on endotoxemia and low-grade inflammation related to obesity. Functional lipids are important ingredients used in food formulation and recent work has revealed the potential impact of some food emulsifiers on metabolism and inflammation in rodents in line with intestinal effects. Of particular interest in this review will be also recent findings on the benefits of dairy polar lipids on human lipid metabolism and their beneficial effects on metabolic inflammation in preclinical models. The review will also address the underlying mechanisms related to the metabolic fate of specific lipids such as sphingomyelin in the distal intestine, the microbiota and some actors of the intestinal barrier. Finally, these recent findings will be considered in the concept of the “food matrix effect” opening perspectives in the nutritional management of metabolic disorders.

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Section: Dietary Fat and Intestinal Crosstalk Between Bile Acids And Gut Microbiotamentioning

confidence: 98%

“…Potential modulations of digestion, absorption and metabolic fate of the dietary lipids. Adapted from Michalski et al (2013);Michalski et al (2016Michalski et al ( , 2017;Bourlieu and Michaski (2015). LBP: lipopolysaccharide binding protein; LPS: lipopolysaccharides.…”

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confidence: 99%