Oral lichen planus: salival biomarkers cortisol, immunoglobulinA, adiponectin

Abstract

OLP patients presented worse psychological profiles and sleep disturbances, as well as higher values for IgA, cortisol, and total proteins than control subjects.

Correlation between salivary cortisol levels and Hospital Anxiety and Depression scores in oral lichen planus and recurrent aphthous stomatitis

“…The mean rank of salivary cortisol in OLP patients was not statistically significantly higher than the control group. This insignificance is in concordance with Girardi et al [22] but dissimilar to other studies [11,16,18,19,20] .…”

“…The mean salivary cortisol level in our group of OLP patients amounted to 0.83 ± 0.40 µg/dL which was higher than the mean of the control group, in concordance with many earlier studies [11,16,[18][19][20] , but the absolute value is lower than that reported in few of these studies [11,16,19,20] . This higher mean cortisol level could be attributed to the earlier time of saliva collection in our study as compared to other studies.…”

“…Our study results suggest high levels of anxiety in OLP patients. This confirms the findings of several previous studies [15,18,20,24] , but contradicts that of Allen et al [12] , Pippi et al [21] and Girardi et al [22] . High levels of depression in our OLP patients contradict the findings of McCartan [15] , Pippi et al [21] and Girardi et al [22] , but is supported by the results of Shah et al [19] .…”

“…Koray et al [11] and Lopez-Jornet et al [18] collected the unstimulated whole saliva sample from their study population unlike other researchers [7,15,16,19] who collected stimulated saliva samples for their study. We have collected unstimulated whole saliva samples from our sample population despite the risk that cortisol can contaminate with gingival crevicular fluid, but the study groups had the same circumstances.…”

“…We have collected unstimulated whole saliva samples from our sample population despite the risk that cortisol can contaminate with gingival crevicular fluid, but the study groups had the same circumstances. Similar to earlier studies [8,9,15,18] , we have made use of the HAD scale for assessing the psychological profile in our sample population.…”