Correlation between salivary cortisol levels and Hospital Anxiety and Depression scores in oral lichen planus and recurrent aphthous stomatitis

Vassandacoumara, Vaishnavee; Daniel, Jonathan M.

doi:10.20517/2573-0002.2017.08

Cited by 4 publications

(15 citation statements)

References 23 publications

(63 reference statements)

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“…Although the present study found no significant difference in salivary level of cortisol among the three groups, this value was the highest in the erosive OLP group, compared with the control group (1.09 vs. 0.98 mg/dL). Vassandacoumara and Daniel reported that salivary level of cortisol in OLP patients was insignificantly higher than that in healthy controls, which was similar to the present findings [19]. Shetty et al found significantly higher serum level of cortisol in erosive OLP patients compared with controls while the difference in this regard was not significant between reticular OLP patients and controls [14].…”

Section: Discussionsupporting

confidence: 89%

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Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus

Jafari

Baharvand²,

Jarahzade³

et al. 2023

J Oral Med Oral Surg

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Oral lichen planus (OLP) is an inflammatory condition of oral mucosa and skin. The present study compared salivary cortisol, depression and anxiety levels of patients with erosive and reticular OLP and healthy controls. In this case-control trial, 69 individuals (23 healthy, 23 erosive OLP and 23 reticular OLP patients) were selected. The participants completed the hospital anxiety and depression scale (HADS) and 5 mL of their unstimulated saliva were collected. Salivary cortisol levels were measured by enzyme-linked immunosorbent assay(ELISA). The comparison of anxiety and depression scores as well as salivary cortisol levels was done one-way analysis of variance (ANOVA) test while the paired comparisons were done by Turkey post hoc test. The mean anxiety score in erosive OLP patients was significantly higher than that in the control and reticular OLP groups. The reticular OLP and control groups had no significant difference in this respect. The three groups were not significantly different regarding the depression score or salivary level of cortisol. The correlation between depression and anxiety was significant but salivary level of cortisol had no correlation with anxiety or depression. This study showed that anxiety control may aid in control of erosive OLP, although further investigations are required.

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Section: Discussionsupporting

confidence: 89%

“…Hospital anxiety and depression scale (HADS) is a commonly used questionnaire for assessment of depression and anxiety in patients [14,19]. The reliability of this questionnaire has been previous confirmed [20].…”

Section: Introductionmentioning

confidence: 99%

Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus

Jafari

Baharvand²,

Jarahzade³

et al. 2023

J Oral Med Oral Surg

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“…In this regard, lack of significance with the other used methods may be due to the low number of reported studies. Out of 10 studies reported [1,8,18,19,20,21,22,23,24,25] in the present meta-analysis, six studies [1,18,19,21,23,24] showed a higher significant level of salivary cortisol in the OLP patients compared with the controls.…”

Section: Discussionmentioning

confidence: 63%

“…The studies were published from 2003 to 2017 and included 269 OLP patients and 268 controls. Four studies were reported from India [1,18,19,20], three from the Middle East [21,22,23], two from Europe [24,25], and one from Brazil [8]. In six studies [1,18,21,22,23,24], the detection method of salivary cortisol level was enzyme-linked immunosorbent assay (ELISA), whereas the remaining methods were radioimmunoassay in one study [8] and the chemiluminescence immunoassay in three studies [19,20,25].…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were reported from India [1,18,19,20], three from the Middle East [21,22,23], two from Europe [24,25], and one from Brazil [8]. In six studies [1,18,21,22,23,24], the detection method of salivary cortisol level was enzyme-linked immunosorbent assay (ELISA), whereas the remaining methods were radioimmunoassay in one study [8] and the chemiluminescence immunoassay in three studies [19,20,25]. Eight studies [1,8,18,19,21,22,23,24] had case-control design and two studies [20,25] had comparative cross-sectional design.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of the Salivary Level of Cortisol in Patients with Oral Lichen Planus: A Meta-Analysis

et al. 2019

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Background and objective: Cortisol, as the main human glucocorticoid, is considered to be a biological marker of stress and anxiety. Since it is known that oral lichen planus (OLP) can appear and worsen during stressful events, cortisol levels have been previously studied in OLP patients. The present meta-analysis aims to assess the salivary concentration of cortisol in OLP patients compared to healthy controls. Materials and methods: Web of Science, PubMed, Cochrane Library, and Scopus databases were searched up to October 2018. The RevMan 5.3 software was used with the mean difference (MD) and 95% confidence intervals (CIs). The CMA 2.0 Software was used to evaluate the publication bias, sensitivity analysis, and meta-regression as possible sources of heterogeneity. Results: 10 studies were analyzed and a total of 269 OLP patients and 268 controls were included. The pooled MD of the salivary levels of cortisol in OLP patients compared with controls was 4.27 ng/mL (95% CI: 2.33, 6.21; P < 0.0001), thus, the salivary level of cortisol in OLP patients was significantly higher than in controls. In Indian-based population studies, a significant difference in the salivary cortisol levels in OLP patients compared with controls was detected (MD = 5.62 ng/mL; 95% CI: 2.67, 8.56; P = 0.0002). In addition, a significant difference in the salivary cortisol levels in the OLP patients compared with the controls was obtained in studies performed with enzyme-linked immunosorbent assay (ELISA) method (MD = 5.33 ng/mL; 95% CI: 2.72, 7.93; P < 0.0001). Conclusion: We suggest that supportive psychological treatment together with the conventional therapy could increase patients’ capability to prevent stress, anxiety, and depression.

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Salivary biomarkers to evaluate psychological disorders in oral lichen planus: A systematic review with meta‐analysis

et al. 2022

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ObjectiveTo analyze the use of salivary biomarkers to identify psychological disorders (anxiety, depression, and stress) in individuals with oral lichen planus (OLP).Materials and MethodsThe search was made in Medline/Pubmed, Scopus, Web of Science, Virtual Health Library, ProQuest, and by cross‐reference. Original case–control, cross‐sectional, and cohort studies, in human subjects (age ≥18 years) with clinical and histopathological diagnosis, with or without the use of psychometric scales, published until June 2021, were included. Random‐effects meta‐analyses, subgroup analyses, and sensitivity were performed. Publication bias was measured using the Egger test and visual inspection of the funnel plot.ResultsA total of 67 articles were found, of which 12 were included in the meta‐analysis. Among the different biomarkers identified, it was only possible to perform a meta‐analysis for cortisol. The mean difference between salivary cortisol levels in patients with OLP compared to controls was 3.43 ng/ml (95% CI: 1.20–5.65) with I2 = 98.9%. Studies considered outliers were removed and based on sensitivity analyses, results did not change, therefore, being stable.ConclusionThe studies analyzed demonstrated that cortisol was the most quantified biomarker to identify psychological disorders; however, DHEA, IgA, adiponectin, and α‐amylase were also evaluated.

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Correlation between salivary cortisol levels and Hospital Anxiety and Depression scores in oral lichen planus and recurrent aphthous stomatitis

Cited by 4 publications

References 23 publications

Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus

Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus

Evaluation of the Salivary Level of Cortisol in Patients with Oral Lichen Planus: A Meta-Analysis

Salivary biomarkers to evaluate psychological disorders in oral lichen planus: A systematic review with meta‐analysis

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