Oral challenge with balsam of Peru

Abstract

A placebo-controlled, double-blind, oral challenge with balsam of Peru was carried out in 221 patients with various types of dermatitis. 210 patients completed the study, and 45 of them experienced a flare of their symptoms after challenge with balsam of Peru but not after placebo. 15 patients reacted to the placebo, and 5 reacted to both balsam and placebo. Specific reactivity to balsam of Peru was seen particularly in patients with positive patch tests to this compound and in some patch-test-negative patients with vesicular hand eczema, ano-genital and axillary eczema. Dietary restriction of the intake of balsams was followed by marked improvement or clearance of the dermatitis in approximately half of the patients who adhered to the diet for at least 1 month.

Systemic Contact Dermatitis

“…Hjorth [47] observed systemic contact dermatitis in balsam ofPeru-sensitive patients who had eaten fiavoured ice cream and orange marmalade. Veien et al [48] challenged 17 patients sensitive to balsam of Peru with an oral dose of 1 g of balsam of Peru. Ten patients reacted to balsam of Peru and one to a placebo.…”

Practical Patch Testing and Chemical Allergens in Contact Dermatitis

“…Classic Presentation : ACD on the face (eyelids), neck and axillae, as well possible stomatitis or cheilitis [ 72,73 ] are common presentations. BOP also may be associated with hand dermatitis [ 74 ] , and diaper dermatitis, as children may become sensitized through the use of baby products used in the diaper region or the diaper's components themselves [ 75,76 ] .…”

“…Potential Ectopic Dermatitis: Potentially Potential Generalized/Systemic Dermatitis : Yes; Airborne contact, and dermatitis due to systemic exposure by inhalation and ingestion ( fl avor and spices in foods) may also occur [ 70,74,77,78 ] .…”

Hämatogene Kontaktekzeme durch Nahrungsmittel

“…Vor al lem das Na tur pro dukt Pe ru balsam wur de in meh re ren Stu di en mit grö-ße ren Pa ti en ten kol lek ti ven un ter sucht [26,41]. Pe ru bal sam setzt sich aus mehr als 180 ver schie de nen Kom po nen ten zu sam men, als Al ler ge ne ste hen Ben zyl ben zoat, Co nife ryl ben zoat, Eu ge nol, Va nil lin und Zim talde hyd im Vor der grund [13,14].…”

“…Als Ge schmacks kor ri genz zu ge setzt, wei sen Pe ru bal sam oder Ein zel kom po nenten auch Kreuz re ak tio nen zu Ge wür zen auf [10,26]. Zehn von 17 Pa ti en ten mit posi ti ven Re ak tio nen auf Par füm mix oder Kolo pho ni um im Pflas ter test zeig ten in ei ner pla ce bo kon trol lier ten Stu die eine Ek zemver schlech te rung nach ora ler Pro vo ka ti on mit 1 g Pe ru bal sam [41]. In ei ner wei te ren Stu die zeig ten 22 von 32 Pa ti en ten mit posi ti vem Pflas ter test mit Pe ru bal sam und/ oder Par füm mi schung bei pla ce bo kon trollier ter Pro vo ka ti on mit 1 g Pe ru bal sam eine Ek zem ver schlech te rung [48].…”