Systemic Contact Dermatitis

Menné, Torkil; Veien, Niels K.

doi:10.1007/978-3-662-10302-9_16

Cited by 20 publications

(30 citation statements)

References 52 publications

(48 reference statements)

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“…Consequently, the Ni-patch-induced oral mucosa lesions are probably related to bowel damage that occurs after ingestion of Ni-containing foods that in turn, causes the A Ni patch may also cause development of general reactions such as itching and dermographia, suggesting that the omPT can effectively identify Ni-sensitive patients. Furthermore, besides reinforcing the observations that Ni intake causes contact stomatitis [2,3] and may trigger a preexistent ACD [4][5][6], our results show that the omPT is more sensitive than the epicutaneous version in recognizing the adverse effects of ingesting Ni- containing foods in a population of symptomatic patients. In this regard, the significant portion of Ni-sensitive patients identified by the omPT, as well as the substantial clinical differences between positive and negative omPT patients further support this simple test as an effective diagnostic tool.…”

Section: Discussionsupporting

confidence: 75%

“…Similarly, Ni exposure through the intestinal mucosa following the ingestion of Ni-containing foods can result in other clinical conditions, including contact stomatitis [2,3]. Several studies have also reported that even small amounts of Ni ingested with a normal diet are enough to flare up a preexistent ACD [4][5][6]. However, these observations are occasional and fragmentary, so the sensitivity to dietary Ni is a condition still poorly understood.…”

mentioning

confidence: 96%

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Oral Mucosa Patch Test: A New Tool to Recognize and Study the Adverse Effects of Dietary Nickel Exposure

Picarelli

Tola

Vallecoccia

et al. 2010

Biol Trace Elem Res

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On contact with the skin, nickel may cause allergic contact dermatitis, which can be diagnosed by an epicutaneous patch test. Nickel exposure via the intestinal mucosa can induce diarrhea, abdominal pain, and swelling. The aim of the present study was to investigate the relationship between these symptoms and nickel intake by means of a novel oral mucosa patch test. Eighty-six patients with intestinal symptoms related to ingestion of nickel-containing foods were submitted to epicutaneous and oral mucosa patch tests for nickel. All patients with positive oral mucosa patch test results were subject to a low-nickel diet and monitored over time. Skin lesions were observed in 33 out of 86 (38.4%) patients evaluated by the epicutaneous patch test. Mucosal lesions were seen in 53 out of 86 (61.6%) patients given the oral mucosa patch test. After 2 months of a low-nickel diet, 52 out of 53 (98.1%) patients showed an improvement of their symptoms. There is a significant correlation between response time of the oral mucosa patch test and the latency of symptoms after ingestion of nickel-containing foods. Consequently, the oral mucosa patch test can be used to recognize and study the adverse effects of dietary nickel exposure that could be defined as allergic contact mucositis. A low-nickel diet is also shown to be an effective treatment for this condition.

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Section: Discussionsupporting

confidence: 75%

mentioning

confidence: 96%

Oral Mucosa Patch Test: A New Tool to Recognize and Study the Adverse Effects of Dietary Nickel Exposure

Picarelli

Tola

Vallecoccia

et al. 2010

Biol Trace Elem Res

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“…1). The results of this study have been repeated and confirmed by several authors [6,12]. The evidence for immunological specificity includes flareup reactions at previous nickel contact sites, for example under metal spectacle frames (Fig.…”

Section: Medicamentssupporting

confidence: 82%

“…The literature on systemic contact dermatitis is now comprehensive. Reviews include Cronin [4], Fisher [5], Menné et al [6] and Veien et al [7]. í Systemic contact dermatitis may occur after the systemic administration of a hapten in persons with contact sensitivity to the hapten.…”

Section: Introductionmentioning

confidence: 99%

Systemic Contact Dermatitis

Veien¹,

Menné

2006

Contact Dermatitis

Self Cite

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“…This definition of food allergy [8] (see [9] for a discussion and references to further guidelines for classification) leads to the inclusion of diseases, such as celiac disease or rare conditions including food-induced nickel allergy (systemic contact dermatitis) [10] , besides IgE-mediated food allergy. While the symptomatology may be suggestive of the disease mechanism, the ultimate diagnosis lies in the demonstration of a pathophysiological immune response that may explain the symptoms.…”

Section: Is It Food Allergy?mentioning

confidence: 99%

Hints for Diagnosis

Poulsen

2015

Food Allergy: Molecular Basis and Clinical Practice

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The diagnosis of food allergy requires responses to two important questions: Does the patient have a food allergy? If so, which foods will elicit allergic symptoms? The first question will most often have to be answered following a physical examination and an interview with the patient and/or caretakers. Based on this, a provisional decision to pursue a food allergy diagnosis may be made after carefully considering other possible reasons for an adverse reaction to a food: aversion, infection, intoxication, or an underlying metabolic disease. To respond to the next question, the anamnesis is highly important in selecting which tests and, ultimately, oral food challenges the patient should undergo to reach the final diagnosis. For the diagnosing doctor, it is important to know and consider the regional pattern of inhalation and food allergies, the food consumption patterns in the local community, and the selection of patients -in terms of both age groups and symptoms -visiting the center.

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Systemic Contact Dermatitis

Cited by 20 publications

References 52 publications

Oral Mucosa Patch Test: A New Tool to Recognize and Study the Adverse Effects of Dietary Nickel Exposure

Oral Mucosa Patch Test: A New Tool to Recognize and Study the Adverse Effects of Dietary Nickel Exposure

Systemic Contact Dermatitis

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