Optimum procedure for the determination of selenium in biological specimens using selenium-77m neutron activation

Abstract

An optimum procedure is outlined for the rapid quantitative determination of trace (>0.06 ,ug) selenium in serum and tissue using 77mSe neutron activation. Sample preparation, irradiation procedures, types of detector assemblies, and spectral analyses and data reduction are discussed. The optimum procedure utilizing a low-power nuclear reactor (~3 X 1011 n/cm2 sec) consisted of irradiating lyophilized tissue samples or dialyzed-lyophilized serum

Endogenous steroid concentrations in human breast tumours determined by high-resolution mass fragmentography (Short Communication)

“…The study involved the technique of combined g.l.c.-mass spectrometry, using the highly specific and sensitive mode of single ion detection (mass fragmentography) at high resolution (10000, 10% valley). Low-resolution mass fragmentography has previously been used for the analysis of oestrogens in urine (Maume et al, 1973) and in plasma (Adlercreutz & Hunneman, 1973).…”