Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite

Wu, You; Chen, Shoucheng; Luo, Pu; Deng, Shudan; Shan, Zhengjie; Fang, Jinghan; Liu, Xingchen; Xie, Jiaxin; Liu, Runheng; Wu, Shiyu; Wu, Xiayi; Chen, Zetao; Yeung, K.W.K.; Liu, Quan

doi:10.1016/j.actbio.2022.02.004

Cited by 25 publications

(27 citation statements)

References 54 publications

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“…Zn is also known to be a potent bone immunomodulator, affecting macrophage polarization and osteoblast differentiation [ 179 ]. Wu et al showed that 1% and 2% nZnHA-doped collagen membranes exhibited superior biocompatibility and stronger promotion of multinucleated giant cells (MNGC) formation in vitro and in vivo [ 147 ]. On the other hand, zinc seems to modulate the biological activity of matrix metalloproteinases (MMP) to regulate collagen degradation [ 180 ].…”

Section: Absorbable Barrier Membranementioning

confidence: 99%

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Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

Ren

Fan

Alkildani³

et al. 2022

IJMS

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Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. Different membrane types provide different biological mechanisms due to their different origins, preparation methods and structures. Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal. This work provides a comparative summary of common barrier membranes used in GBR, focusing on recent advances in collagen membranes and their biological mechanisms. In conclusion, the review article highlights the biological and regenerative properties of currently available barrier membranes with a particular focus on bioresorbable collagen-based materials. In addition, the advantages and disadvantages of these biomaterials are highlighted, and possible improvements for future material developments are summarized.

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Section: Absorbable Barrier Membranementioning

confidence: 99%

“…Wu 2022 [147] nZnHA-doped collagen membranes 1% and 2% nZnHA-doped collagen membranes exhibited superior biocompatibility and stronger promotion of multinucleated giant cells (MNGC) formation in vitro and in vivo.…”

Section: Znmentioning

confidence: 99%

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

Ren

Fan

Alkildani³

et al. 2022

IJMS

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“…However, pure collagen membranes (non‐cross‐linked) have lower compressive strength and easily collapse into bone defects, thus impairing the GBR procedure. Cross‐linking methods have been developed to strengthen the collagen membrane to decelerate the degradation speed, such as dehydrothermal treatment 21,22,23 . The combination of non‐cross‐linked collagen membranes and bone substitute grafts is another solution in most clinical settings 24,25 .…”

Section: Introductionmentioning

confidence: 99%

A comparative in vitro and in vivo study of porcine‐ and bovine‐derived non‐cross‐linked collagen membranes

et al. 2022

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The porcine-derived non-cross-linked collagen membrane Bio-gide ® (BG) and the bovine-derived non-cross-linked collagen membrane Heal-all ® (HA) were compared to better understand their in vitro biophysical characteristics and in vivo degradation patterns as a reference for clinical applications. It was showed that the porosity, specific surface area, pore volume and pore diameter of BG were larger than those of HA (64.5 ± 5.2% vs. 48.6 ± 6.1%; 18.6 ± 2.8 m 2 /g vs. 2.3 ± 0.6 m 2 /g; 0.114 ± 0.002 cm 3 /g vs. 0.003 ± 0.001 cm 3 /g; 24.4 ± 3.5 nm vs. 7.3 ± 1.7 nm, respectively); the average swelling ratio of BG was higher than that of HA (412.6 ± 41.2% vs. 270.0 ± 2.7%); the tensile strength of both dry and wet HA was higher than those of BG (18.26 ± 3.27 MPa vs. 4.02 ± 1.35 MPa; 2.24 ± 0.21 MPa vs. 0.16 ± 0.02 MPa, respectively); 73% of HA remained after 72 h in collagenase solution, whereas only 8.2% of BG remained. A subcutaneous rat implantation model revealed that, at 3, 7, 14, 28, and 56 days postmembrane implantation, there were more total inflammatory cells, especially more M1 and M2 polarized macrophages and higher M2/M1 ratio in BG than in HA; in addition, the fibrous capsule around BG was also thicker than that around HA. Moreover, concentrations of dozens of cytokines including interleukin-2(IL-2), IL-7, IL-10 and so forth. in BG were higher than those in HA. It is suggested that BG and HA might be suitable for different clinical applications according to their different characteristics.

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“…Inorganic materials with good biocompatibility, such as hydroxyapatite and calcium phosphate, are widely used in bone tissue regeneration [ 7 , 8 , 9 ]. The introduction of inorganic materials into natural polymerbased hydrogels can effectively improve the mechanical properties of these hydrogels and provide a corresponding biological function of inorganic material [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels

Zhao

et al. 2022

IJMS

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Natural polymer hydrogels have good mechanical properties and biocompatibility. This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels. Hyaluronic acid (HA) and gelatin (Gel) were modified with methacrylate anhydride. The catechin group was further introduced into the HA chain inspired by the adhesion chemistry of marine mussels. Hence, the double-crosslinked hydrogel (HG) was formed by the photo-crosslinking of double bonds and the oxidative-crosslinking of catechins. Moreover, hydroxyapatite was introduced into HG to form hydroxyapatite-enhanced hydrogels (HGH). The results indicate that, with an increase in crosslinking network density, the stiffness of hydrogels became higher; these hydrogels have more of a compact pore structure, their anti-degradation property is improved, and swelling property is reduced. The introduction of hydroxyapatite greatly improved the mechanical properties of hydrogels, but there is no change in the stability and crosslinking network structure of hydrogels. These inorganic phase-enhanced hydrogels were expected to be applied to tissue engineering scaffolds.

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Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite

Cited by 25 publications

References 54 publications

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

A comparative in vitro and in vivo study of porcine‐ and bovine‐derived non‐cross‐linked collagen membranes

Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels

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