Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists

Hillaert, S; Bossche, W. Van den

doi:10.1016/s0021-9673(02)01247-5

Cited by 89 publications

(44 citation statements)

References 22 publications

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“…The most commonly used methods for this purpose were chromatographic methods such as HPTLC and TLC (5,6), LC (7,8), HPLC (9) and CE (10,11). The UPLC-MS/MS method was applied for simultaneous determination of telmisartan and hy- Brought to you by | MIT Libraries Authenticated Download Date | 5/9/18 2:15 PM drochlorotiazide in human plasma (12).…”

Section: Valsartan (Val) (S)-3-methyl-2-(n-{[2'mentioning

confidence: 99%

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

et al. 2017

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Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin -D1, D2 and D3, for valsartan and pravastatin -D1 and D3, for valsartan and atorvastatin -D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32.48 mg mL -1 for valsartan, 8.16-28.56 mg mL -1 for fluvastatin, 14.40-39.90 mg mL -1 for atorvastatin and 9.60-48.00 mg mL -1 for pravastatin. Determination coefficients were in the range of 0.989-0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations.

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Section: Valsartan (Val) (S)-3-methyl-2-(n-{[2'mentioning

confidence: 99%

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

et al. 2017

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“…BP described a RP-HPLC method for assay of Amlodipine besylate and potentiometric titrations for assay of Atorvastatin calcium, Losartan potassium and Valsartan [3]. Several methods have been published for simultaneous determination of studied drugs in their combinations with each other, these methods depends on different analytical technique like Spectrophotometry [4][5][6][7][8][9][10][11], Spectrofluorimetry [12][13][14], Capillary Electrophoresis [15][16][17][18], HPTLC and TLC [19][20][21] and HPLC coupled with UV detector [21][22][23][24][25][26][27][28][29], fluorescence detector [30] and mass spectrometer detector [31][32][33][34]. Our scope is development of a validated analytical method for assay of these drugs in combination with each other in its pharmaceutical preparations and it should be characterized by a simplicity, accuracy, preciseness and sensitivity.…”

Section: Valsartan Is Chemically Described As N-(1-oxopentyl)-n-[[2mentioning

confidence: 99%

Quantitative Determination of Amlodipine Besylate, Losartan Potassium, Valsartan and Atorvastatin Calcium by HPLC in their Pharmaceutical Formulations

Abdelaziz¹

2014

J Chromat Separation Techniq

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Amlodipine besylate is a calcium channel blocker which is used in treatment of hypertension alone or in combination with other antihypertensive drugs like angiotensin-II-receptor antagonists (ARA II) group (Losartan potassium and Valsartan) or in combination with anti hyperlipidemic agent like Atorvastatin calcium. RP-HPLC method was developed for the assay of these drugs. The method was performed by reversed phase high performance liquid chromatography using a mobile phase 0.01 M ammonium acetate buffer (pH 5.5): acetonitrile with detection at 240 nm on a spherical monomeric C18 column (250 mm × 4.6 mm, 5 μm) at flow rate of 1.5 ml/min. The proposed method was validated in terms of linearity ranged between [(2-12, 10-60, 16-96, 4-24

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“…In order to make the analysis possible, addition of sodium dodecyl sulfate (SDS) or cyclodextrin in the running buffer is necessary. 6 Therefore, with the aim of studying the simultaneous separation performance of CTD, HCT and LOS by CZE mode through the use of simple electrolyte system, glycine buffer (pH 9.7), carbonate buffer (pH 10.3) and phosphate buffer (pH 12.0) were investigated.…”

Section: Ph Selectionmentioning

confidence: 99%

“…Among the analytical methodologies used, the following can be stressed: super-critical fluid chromatography, 3 high performance liquid chromatography (HPLC), 4 and UVVisible spectrophotometry. 5 The analysis of antihypertensive and diuretic drugs by capillary electrophoresis (CE) presents different ways of separation, such as, capillary zone electrophoresis (CZE) 6 and micellar electrokinetic capillary chromatography (MEKC). 7 In the CE methodologies published for simultaneous analysis of LOS/HCT association, analysis time is higher than 5 min, or use additives such as cyclodextrins or sodium dodecylsulphate (SDS) in the running buffer, 8,9 or were carried out through the capillary electrochromatography (CEC).…”

Section: Introductionmentioning

confidence: 99%

Determination of losartan associated with chlorthalidone or hydrochlorothiazide in capsules by capillary zone electrophoresis

Balesteros¹,

Faria²,

Oliveira³

2007

J. Braz. Chem. Soc.

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Uma metodologia alternativa por eletroforese capilar de zona (ECZ) é proposta para a análise de losartan potássio (LOS) associado com clortalidona (CTD) ou hidroclorotiazida (HCT) em cápsulas, usando 50 mmol L -1 de tampão carbonato de sódio com detecção em 226 nm. O sistema de eletrólito foi otimizado, levando em consideração o perfil do pico, resolução, tempo de análise, estabilidade da linha base e repetibilidade (ausência de adsorção). O método foi aplicado com sucesso na análise de formulações farmacêuticas adquiridas em farmácias de manipulação. Os analitos apresentaram boa separação na linha base em menos de 5 min. Os resultados obtidos não apresentaram diferença signicativa no intervalo de 95% de confiança em relação ao valor de referência. O método pode ser aplicado para a análise destes compostos ou empregado em outros formulações framacêuticas similares contendo estas drogas.An alternative methodology by capillary zone electrophoresis (CZE) is proposed for the determination of losartan potassium (LOS) associated with chlorthalidone (CTD) or hydrochlorothiazide (HCT) in capsules, using 50 mmol L -1 of sodium carbonate buffer with detection at 226 nm. The electrolyte system was optimized, taking into account peak profiles, resolution, run times, baseline stability and repeatability (adsorption absence). The method was successfully applied to the analysis of pharmaceutical formulations purchased in manipulation drugstores. The analytes were baseline separated in less than 5 min. The results did not present significant difference in the 95% confidence interval in relation to the label claim values. The method can be applied to analyze these compounds and could also be employed in other similar formulated products containing these drugs.

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Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists

Cited by 89 publications

References 22 publications

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

Quantitative Determination of Amlodipine Besylate, Losartan Potassium, Valsartan and Atorvastatin Calcium by HPLC in their Pharmaceutical Formulations

Determination of losartan associated with chlorthalidone or hydrochlorothiazide in capsules by capillary zone electrophoresis

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