Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

Abstract

Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin -D1, D2 and D3, for valsartan and pravastatin -D1 and D3, for valsartan and atorvastatin -D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32.48 mg mL -1 for valsartan, 8.16-28.56 mg mL -1 for fluvastatin, 14.40-39.90 mg mL -1 for atorvastatin and 9.60-48.00 mg mL -1 for pravastatin. Determination coefficients were in the range of 0.989-0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations.

Determination of chloropyramine in biological material by method of derivative spectrophotometry

“…Ключевые слова: хлоропирамина гидрохлорид; биологический материал; метод производной спектрофотометрии ВСТУП Метод похідної спектрофотометрії в УФ-області спектра широко застосовується у фармацевтичному та хіміко-токсикологічному аналізі (ХТА) для ідентифікації та кількісного визначення препаратів у сумішах ліків [1,2], лікарських формах [3,4], а також у біологічних об'єктах [5,6]. У сучасних дослідженнях лікарських препаратів метод похідної спектрофотометрії використовується у сполученні з хроматографічними методами [7,8].…”

Derivative optical spectroscopy of thin films of alkaline-earth titanates: Critical points

“…However particular absorption features corresponding to interband optical transitions are often complicated to resolve. Derivative spectroscopy is a commonly used technique that enables to resolve the overlapping and nearby lying absorption peaks in case of a multicomponent material that cannot be easily identified in the original absorption spectrum [9,10]. The method uses higher-order derivatives of absorbance or dielectric function with respect to the wavelength or photon energy.…”