Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of several angiotensin-II-receptor antagonists

Hillaert, S; Beer, T.R.M. De; Beer, Jacques O. De; Bossche, W. Van den

doi:10.1016/s0021-9673(02)01832-0

Cited by 70 publications

(37 citation statements)

References 25 publications

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“…The most commonly used methods for this purpose were chromatographic methods such as HPTLC and TLC (5,6), LC (7,8), HPLC (9) and CE (10,11). The UPLC-MS/MS method was applied for simultaneous determination of telmisartan and hy- Brought to you by | MIT Libraries Authenticated Download Date | 5/9/18 2:15 PM drochlorotiazide in human plasma (12).…”

Section: Valsartan (Val) (S)-3-methyl-2-(n-{[2'mentioning

confidence: 99%

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

et al. 2017

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Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin -D1, D2 and D3, for valsartan and pravastatin -D1 and D3, for valsartan and atorvastatin -D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32.48 mg mL -1 for valsartan, 8.16-28.56 mg mL -1 for fluvastatin, 14.40-39.90 mg mL -1 for atorvastatin and 9.60-48.00 mg mL -1 for pravastatin. Determination coefficients were in the range of 0.989-0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations.

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Section: Valsartan (Val) (S)-3-methyl-2-(n-{[2'mentioning

confidence: 99%

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

et al. 2017

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“…BP described a RP-HPLC method for assay of Amlodipine besylate and potentiometric titrations for assay of Atorvastatin calcium, Losartan potassium and Valsartan [3]. Several methods have been published for simultaneous determination of studied drugs in their combinations with each other, these methods depends on different analytical technique like Spectrophotometry [4][5][6][7][8][9][10][11], Spectrofluorimetry [12][13][14], Capillary Electrophoresis [15][16][17][18], HPTLC and TLC [19][20][21] and HPLC coupled with UV detector [21][22][23][24][25][26][27][28][29], fluorescence detector [30] and mass spectrometer detector [31][32][33][34]. Our scope is development of a validated analytical method for assay of these drugs in combination with each other in its pharmaceutical preparations and it should be characterized by a simplicity, accuracy, preciseness and sensitivity.…”

Section: Valsartan Is Chemically Described As N-(1-oxopentyl)-n-[[2mentioning

confidence: 99%

Quantitative Determination of Amlodipine Besylate, Losartan Potassium, Valsartan and Atorvastatin Calcium by HPLC in their Pharmaceutical Formulations

Abdelaziz¹

2014

J Chromat Separation Techniq

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Amlodipine besylate is a calcium channel blocker which is used in treatment of hypertension alone or in combination with other antihypertensive drugs like angiotensin-II-receptor antagonists (ARA II) group (Losartan potassium and Valsartan) or in combination with anti hyperlipidemic agent like Atorvastatin calcium. RP-HPLC method was developed for the assay of these drugs. The method was performed by reversed phase high performance liquid chromatography using a mobile phase 0.01 M ammonium acetate buffer (pH 5.5): acetonitrile with detection at 240 nm on a spherical monomeric C18 column (250 mm × 4.6 mm, 5 μm) at flow rate of 1.5 ml/min. The proposed method was validated in terms of linearity ranged between [(2-12, 10-60, 16-96, 4-24

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“…Several electrochemical methods were reported for their quantification [14][15][16][17]. Different separation techniques such as electrophoresis [18][19] and high-performance liquid chromatography (HPLC) [20][21][22][23][24] were reported for the separation and determination of several members of the studied drugs. None of the reported screening methods included olmesartan which is the most modern member of the studied class [25].…”

Section: Introductionmentioning

confidence: 99%

Application of high-performance thin-layer chromatography for screening and simultaneous determination of some angiotensin II receptor antagonists in dosage forms and plasma

Hussein¹,

El-Wadood²,

Abdallah³

et al. 2014

Journal of Planar Chromatography – Modern TLC

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A high-performance thin-layer chromatographic (HPTLC) method was performed for simultaneous quantification of four angiotensin II receptor antagonists, namely, losartan, irbesartan, valsartan, and olmesartan. The method based on HPTLC separation of the four drugs using reflectance-absorbance mode at 255 nm. Separation was carried out on pre-coated silica gel HPTLC plates, using chloroform-glacial acetic acid (

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Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of several angiotensin-II-receptor antagonists

Cited by 70 publications

References 25 publications

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

Quantitative Determination of Amlodipine Besylate, Losartan Potassium, Valsartan and Atorvastatin Calcium by HPLC in their Pharmaceutical Formulations

Application of high-performance thin-layer chromatography for screening and simultaneous determination of some angiotensin II receptor antagonists in dosage forms and plasma

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