Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography

Lee, Sang-Won; Yoo, Ji Yeong; Kang, Jin Ho; Kang, Moon-Sik; Jung, Soon Hee; Chong, Yosep; Su, Dong Ming; Han, Kyung Hee; Kim, Beop Min

doi:10.1364/oe.16.002709

Cited by 26 publications

(16 citation statements)

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“…Each reading covers ~ 4 × 4 μm area which is the size of a single or small group of collagen fibers. In the future, functional extensions of OCT can also allow for interrogating the anisotropy and birefringence properties of cervical samples using polarization sensitive OCT [23, 38, 39]. …”

Section: Discussionmentioning

confidence: 99%

“…A typical OCT system can achieve a high axial resolution at the micron level, a penetration depth up to 2 mm, and video rate data acquisition, and thus emerges as a promising image modality to image a variety of organ systems [17–20]. In particular, efforts have been made to image cervical tissues for cancer detection [21–23] by analyzing the layered structure of the epithelium, the basement membrane, and the stroma. In addition to cancerous structure, OCT can be also used to image the collagen fiber network.…”

Section: Introductionmentioning

confidence: 99%

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Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women

et al. 2016

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The structural integrity of the cervix in pregnancy is necessary for carrying a pregnancy until term, and the organization of human cervical tissue collagen likely plays an important role in the tissue’s structural function. Collagen fibers in the cervical extracellular matrix exhibit preferential directionality, and this collagen network ultrastructure is hypothesized to reorient and remodel during cervical softening and dilation at time of parturition. Within the cervix, the upper half is substantially loaded during pregnancy and is where the premature funneling starts to happen. To characterize the cervical collagen ultrastructure for the upper half of the human cervix, we imaged whole axial tissue slices from non-pregnant and pregnant women undergoing hysterectomy or cesarean hysterectomy respectively using optical coherence tomography (OCT) and implemented a pixel-wise fiber orientation tracking method to measure the distribution of fiber orientation. The collagen fiber orientation maps show that there are two radial zones and the preferential fiber direction is circumferential in a dominant outer radial zone. The OCT data also reveal that there are two anatomic regions with distinct fiber orientation and dispersion properties. These regions are labeled: Region 1—the posterior and anterior quadrants in the outer radial zone and Region 2—the left and right quadrants in the outer radial zone and all quadrants in the inner radial zone. When comparing samples from nulliparous vs multiparous women, no differences in these fiber properties were noted. Pregnant tissue samples exhibit an overall higher fiber dispersion and more heterogeneous fiber properties within the sample than non-pregnant tissue. Collectively, these OCT data suggest that collagen fiber dispersion and directionality may play a role in cervical remodeling during pregnancy, where distinct remodeling properties exist according to anatomical quadrant.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women

et al. 2016

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“…A linear fitting procedure was used to quantify the attenuation of the degrees-of-polarization signal. This approach resulted in sensitivity and specificity to detect CIN of 94.7 and 71.2 %, respectively [47]. An OCT image of a CIN I lesion is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Optical biopsy of epithelial cancers by optical coherence tomography (OCT)

et al. 2013

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Optical coherence tomography (OCT) is an optical technique that measures the backscattering of near-infrared light by tissue. OCT yields in 2D and 3D images at micrometer-scale resolution, thus providing optical biopsies, approaching the resolution of histopathological imaging. The technique has shown to allow in vivo differentiation between benign and malignant epithelial tissue, through qualitative assessment of OCT images, as well as by quantitative evaluation, e.g., functional OCT. This study aims to summarize the principles of OCT and to discuss the current literature on the diagnostic value of OCT in the diagnosis of epithelial (pre)malignant lesions. The authors did a systematic search of the electronic databases PubMed and Embase on OCT in the diagnostic process of (pre)malignant epithelial lesions. OCT is able to differentiate between benign and (pre)malignant lesions of epithelial origin in a wide variety of tissues. In this way, OCT can detect skin cancers, oral, laryngeal, and esophageal cancer as well as genital and bladder cancer. OCT is an innovative technique which enables an optical biopsy of epithelial lesions. The incorporation of OCT in specific tools, like handheld and catheter-based probes, will further improve the implementation of this technology in daily clinical practice.

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“…This design uses a single input polarization state (SIPS) to probe the birefringence of a non-diattenuating sample. While PS-OCT itself has undergone significant improvements in speed, sensitivity [5], flexibility [6, 7] and processing [8, 9] during its 20-year history, the underlying combination of polarization controlling components (PCCs) used in SIPS schemes has not. To the best of our knowledge, among all demonstrated systems that use a SIPS, all but one [10] send circularly polarized light to the sample arm and interfere it with 45-degree linearly polarized light from the reference arm.…”

Section: Introductionmentioning

confidence: 99%

Design considerations for polarization-sensitive optical coherence tomography with a single input polarization state

Lurie

Moritz

Ellerbee

2012

Biomed. Opt. Express

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Using a generalized design for a polarization-sensitive optical coherence tomography (PS-OCT) system with a single input polarization state (SIPS), we prove the existence of an infinitely large design space over which it is possible to develop simple PS-OCT systems that yield closed form expressions for birefringence. Through simulation and experiment, we validate this analysis by demonstrating new configurations for PS-OCT systems, and present guidelines for the general design of such systems in light of their inherent inaccuracies. After accounting for systemic errors, alternative designs exhibit similar performance on average to the traditional SIPS PS-OCT system. This analysis could be extended to systems with multiple input polarization states and could usher in a new generation of PS-OCT systems optimally designed to probe specific birefringent samples with high accuracy.

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Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography

Cited by 26 publications

References 0 publications

Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women

Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women

Optical biopsy of epithelial cancers by optical coherence tomography (OCT)

Design considerations for polarization-sensitive optical coherence tomography with a single input polarization state

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