Oocytes in the empty follicle: a controversial syndrome

Aktaş, Mustafa Sinan; Beckers, Nicole G. M.; Inzen, Wouter G. van; Verhoeff, Arie; Jong, Diederick de

doi:10.1016/j.fertnstert.2005.05.060

Cited by 38 publications

(48 citation statements)

References 39 publications

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“…Although in the first cycle of the patient reported by Uygur et al (21) there was no recorded b-hCG, the fact that the EFS was recurrent and that the level of b-hCG was optimal in the second cycle led us to consider it GEFS. Furthermore, one patient was excluded from the case report by Asch et al (22) because the b-hCG was intentionally withheld to avoid ovarian hyperstimulation syndrome, and 2 patients were excluded from the report by Aktas et al (23) because of premature ovulation.…”

Section: Resultsmentioning

confidence: 99%

“…It is evident from Table 3 that 41% of patients (9 of 22) had male factor infertility. The average age of the 14 patients included in the report by Aktas et al (23), which represents the main bulk of reported GEFS, is 35 years. The remaining 8 patients with GEFS have an average age of 32 years, indicating an average age of 33 years for all patients with GEFS.…”

Section: Fertility and Sterility âmentioning

confidence: 99%

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Empty follicle syndrome: the reality of a controversial syndrome, a systematic review

Stevenson

Lashen

2008

Fertility and Sterility

104

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Section: Resultsmentioning

confidence: 99%

Section: Fertility and Sterility âmentioning

confidence: 99%

Empty follicle syndrome: the reality of a controversial syndrome, a systematic review

Stevenson

Lashen

2008

Fertility and Sterility

104

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“…Different theories have been proposed, among them: ovarian aging, insufficient dosage and genetic receptor changes (Toledo et al, 1996;Aktas et al, 2005). Blazquez et al (2014) published a retrospective study including 12,483 oocyte donation cycles.…”

Section: Discussionmentioning

confidence: 99%

Comparison of two different dosage of GnRH agonist as ovulation trigger in oocyte donors: a randomized controled trial

Zarcos

Mejia

Stefani

et al. 2017

JBRA Assisted Reproduction

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Objective: To compare the results obtained with two different GnRH agonist dosages: 0.3mg versus 0.4mg to trigger ovulation in oocyte donor cycles.Methods: Experimental controlled randomized trial including 40 patients from a private practice center. The patients were randomized into two groups. Group A received a single dose of Triptorelin 0.3mg (Decapeptyl ® ) 36 hours before pick-up. Group B patients received Triptorelin 0.4mg (Decapeptyl ® ) before pick-up to final oocyte maturation. We evaluated the total number of oocytes collected, the number of mature oocytes and total days of ovarian stimulation.Results: The average of total collected oocytes were 16 (Group A) versus 15 (Group B), and the mean number of mature oocytes were 13 versus 12 respectively. The only variable showing a difference was the percentage of mature oocytes, which was greater in Group A, resulting in 84.6%, in contrast with those treated with 0.4mg of Triptorelin (78.6%), although these differences were not statistical significant (p=0.35). Days of stimulation did not differ between groups. No cases of empty follicle syndrome were reported.Conclusions: We found that an increase from 0.3 to 0.4mg of triptorelin in an oocyte donation program might not improve outcomes. Nevertheless, more studies might be necessary, not only in oocyte donors but in sterile women as well, to evaluate how GnRH agonist dosage could affect the results among other factors.

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“…EFS were first reported by Coulam et al 1 Prevalence of EFS range from 0.045-7%. 2,3 Empty follicle syndrome (EFS) is mainly two types-Genuine EFS-failure to retrieve oocytes despite optimal Serum β-HCG level on the day of oocytes retrieval and False EFSfailure to retrieve oocytes in presence of low Serum β-HCG level (40Iu/L) due to error in the administration or bioavailability of HCG .Study by Stevenson et al reviewed that 33% of EFS were genuine & 67% were false. 4 Risk factors for EFS are advanced maternal age, longer duration of infertility, higher base line FSH & lower serum Estradiol (E2) level before HCG injection.…”

Section: Introductionmentioning

confidence: 99%