One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles

Abstract

A novel and simple route to synthesize ultrasmall silica nanoparticles having hydrodynamic diameters under 10 nm for imaging and therapeutic applications.

The emergence of mass spectrometry for characterizing nanomaterials. Atomically precise nanoclusters and beyond

“…Such deconvolution approaches with ESI-MS measurements were found to be well-adapted for solving mass distributions of polydisperse gold nanoclusters 51,[160][161][162][163][164][165] as well as for ultrasmall Gd-based silica NPs. [166][167][168][169][170][171][172][173]…”

Synthesis of triethoxysilylated cyclen derivatives, grafting on magnetic mesoporous silica nanoparticles and application to metal ion adsorption

“…The resulting mixture was stirred at 60 C (argon atmosphere) for 48 h. Then, the solvent was evaporated under reduced pressure and the crude product was obtained as colorless solid (1.16 g, 100% yield) without any purication. 1 Synthesis of tri-tert-butyl-2,2 0 ,2 00 -(10-(3-((3-(triethoxysilyl) propyl)thio)propyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetate, L2-t Bu. In a 50 mL Schlenk tube under nitrogen, tritert-butyl-2,2 0 ,2 00 -(10-allyl-1,4,7,10-tetraazacyclododecane-1,4,7triyl)triacetate 4 (554.8 mg, 2.06 mmol) and 2,2-dimethoxy-1,2diphenylethanone (105.3 mg, 0.41 mmol) were dissolved in anhydrous THF (10.0 mL).…”

“…Then (3-mercaptopropyl)triethoxysilane (489.9 g, 2.06 mmol) was added and the stirred mixture was irradiated with a UV lamp at 365 nm under argon atmosphere for 72 h. Then, the solvent was removed under reduced pressure and the desired product L2-t Bu was obtained as yellow oil (1.62 g, 99% yield). 1 Synthesis of tri-tert-butyl 10-((1-(3-(triethoxysilyl)propyl)-1H-1,2,3-triazol-4-yl)methyl)-1,4,7,10-tetraazacyclododecane-1,4,7triacetate, L3-t Bu. In a 10 mL microwave reaction tube, tri-tertbutyl 2,2 0 ,2 00 -(10-(prop-2-yn-1-yl)-1,4,7,10tetraazacyclododecane-1,4,7-triyl)triacetate 5 (50 mg, 0.09 mmol) CuBr(PPh 3 ) 3 (11 mg, 0.012 mmol) and (3-azidopropyl) triethoxysilane (30 mg, 0.12 mmol) were added.…”

“…Aer completion of the reaction, the solvent was removed under reduced pressure and the desired product L3-t Bu was obtained. 1…”

“…The anchoring of cyclen derivatives on silica-based materials has attracted attention over the last two decades. The main application concerns magnetic resonance imaging [1][2][3][4][5][6][7][8][9] or radiolabelling 10,11 with metal-DOTA-functionalized silica-based nanoparticles for theranostic applications, but not only. Other applications relate to ESR studies with Cu(II), 12 or Cu(II) catalysis, 13 Pd(II) recovery, 14 or photoresponsive materials with Eu(III) or Tb(III).…”