Synthesis of triethoxysilylated cyclen derivatives, grafting on magnetic mesoporous silica nanoparticles and application to metal ion adsorption

Li, Hao; Ménard, Mathilde; Vardanyan, Ani; Charnay, Clarence; Raehm, Laurence; Oliviero, E.; Seisenbaeva, Gulaim A.; Pleixats, Roser; Durand, Jean‐Olivier

doi:10.1039/d1ra01581h

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…Single-crystalline silicon wafers were purchased from Siltronix (Archamps, France). An alkene semicarbazide linker was synthesized, as described in [ 44 ]. Another batch was kindly provided by our collaborators from ICGM, Montpellier; an anti-HER2 antibody was provided by a collaborator from CSIRO; Hydrofluoric acid (HF; 49%) was purchased from J. T. Baker (Center Valley, PA, USA).…”

Section: Methodsmentioning

confidence: 99%

Combination of Chemotherapy and Mild Hyperthermia Using Targeted Nanoparticles: A Potential Treatment Modality for Breast Cancer

et al. 2023

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Despite the clinical benefits that chemotherapeutics has had on the treatment of breast cancer, drug resistance remains one of the main obstacles to curative cancer therapy. Nanomedicines allow therapeutics to be more targeted and effective, resulting in enhanced treatment success, reduced side effects, and the possibility of minimising drug resistance by the co-delivery of therapeutic agents. Porous silicon nanoparticles (pSiNPs) have been established as efficient vectors for drug delivery. Their high surface area makes them an ideal carrier for the administration of multiple therapeutics, providing the means to apply multiple attacks to the tumour. Moreover, immobilising targeting ligands on the pSiNP surface helps direct them selectively to cancer cells, thereby reducing harm to normal tissues. Here, we engineered breast cancer-targeted pSiNPs co-loaded with an anticancer drug and gold nanoclusters (AuNCs). AuNCs have the capacity to induce hyperthermia when exposed to a radiofrequency field. Using monolayer and 3D cell cultures, we demonstrate that the cell-killing efficacy of combined hyperthermia and chemotherapy via targeted pSiNPs is 1.5-fold higher than applying monotherapy and 3.5-fold higher compared to using a nontargeted system with combined therapeutics. The results not only demonstrate targeted pSiNPs as a successful nanocarrier for combination therapy but also confirm it as a versatile platform with the potential to be used for personalised medicine.

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Section: Methodsmentioning

confidence: 99%

Combination of Chemotherapy and Mild Hyperthermia Using Targeted Nanoparticles: A Potential Treatment Modality for Breast Cancer

et al. 2023

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“…32 Firstly, Fe 3 O 4 particles coated with a silica layer have improved chemical stability and ease of functionalisation. 33 Another common strategy for functionalisation is to incorporate electron-rich atoms such as oxygen, nitrogen and sulfur-based in the hard-soft-acid-base (HSAB) theory to take advantage of their ability to coordinate or chelate metal ions. 34 The allyl thiourea (ATU) molecule contains S, N atoms and a vinyl group that can bind strongly to gold ions and polymerise easily.…”

Section: Introductionmentioning

confidence: 99%

Turning waste into wealth: efficient and rapid capture of gold from electronic waste with a thiourea functionalised magnetic core stirring rod adsorbent and its application for heterogeneous catalysis

Pan

et al. 2022

Green Chem.

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Comparison of adsorption of U(VI) by magnetic MCM-41, MCM-48 and SBA-15 mesoporous silicas

Bi,

Cai,

Xiong

et al. 2024

J Radioanal Nucl Chem

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Synthesis of triethoxysilylated cyclen derivatives, grafting on magnetic mesoporous silica nanoparticles and application to metal ion adsorption

Abstract: The adsorption of metal ions through ligand-functionalized magnetic mesoporous silica nanoparticles is described.

Cited by 5 publications

References 31 publications

Combination of Chemotherapy and Mild Hyperthermia Using Targeted Nanoparticles: A Potential Treatment Modality for Breast Cancer

Combination of Chemotherapy and Mild Hyperthermia Using Targeted Nanoparticles: A Potential Treatment Modality for Breast Cancer

Turning waste into wealth: efficient and rapid capture of gold from electronic waste with a thiourea functionalised magnetic core stirring rod adsorbent and its application for heterogeneous catalysis

Comparison of adsorption of U(VI) by magnetic MCM-41, MCM-48 and SBA-15 mesoporous silicas

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