The emergence of mass spectrometry for characterizing nanomaterials. Atomically precise nanoclusters and beyond

Comby‐Zerbino, Clothilde; Dagany, Xavier; Chirot, Fabien; Dugourd, Philippe; Antoine, Rodolphe

doi:10.1039/d1ma00261a

Cited by 30 publications

(32 citation statements)

References 248 publications

(234 reference statements)

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“…For NP characterization, CDMS contributes to understanding their elemental, molecular, chemical state, and structural information. Therefore, it has been applied to characterize various nanostructures, such as metal nanoclusters containing gold or silver [ 152 , 153 ]. For VLPs, some modalities of MS, such as native electrospray ionization MS, have been used to assess the M w of VLPs derived from Norovirus West Chester GI.1., CPMV, and bacteriophages P22 and T5 [ 154 ].…”

Section: Characterizationmentioning

confidence: 99%

Virus-like Particles: Fundamentals and Biomedical Applications

Mejía-Méndez

Vázquez-Duhalt²,

Hernández

et al. 2022

IJMS

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Nanotechnology is a fast-evolving field focused on fabricating nanoscale objects for industrial, cosmetic, and therapeutic applications. Virus-like particles (VLPs) are self-assembled nanoparticles whose intrinsic properties, such as heterogeneity, and highly ordered structural organization are exploited to prepare vaccines; imaging agents; construct nanobioreactors; cancer treatment approaches; or deliver drugs, genes, and enzymes. However, depending upon the intrinsic features of the native virus from which they are produced, the therapeutic performance of VLPs can vary. This review compiles the recent scientific literature about the fundamentals of VLPs with biomedical applications. We consulted different databases to present a general scenario about viruses and how VLPs are produced in eukaryotic and prokaryotic cell lines to entrap therapeutic cargo. Moreover, the structural classification, morphology, and methods to functionalize the surface of VLPs are discussed. Finally, different characterization techniques required to examine the size, charge, aggregation, and composition of VLPs are described.

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Section: Characterizationmentioning

confidence: 99%

Virus-like Particles: Fundamentals and Biomedical Applications

Mejía-Méndez

Vázquez-Duhalt²,

Hernández

et al. 2022

IJMS

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“…3a that reveals the presence of Au 7 (S-PEG 12 -CO 2 H) 7–8 and Au 10 (S-PEG 12 -CO 2 H) 10 clusters (peaks (1)–(2) and (3) respectively) (details in Section S7, ESI†). 36 Peaks labelled (i)–(iii) originate from ligand oligomers therefore unidentified PEG fragments could arguably account for the unlabelled peaks in the m / z = 1900–2300 region. Fig.…”

Section: Resultsmentioning

confidence: 99%

Facile one-pot synthesis of white emitting gold nanocluster solutions composed of red, green and blue emitters

et al. 2022

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“…The properties of such NCs can be determined using experimental and theoretical approaches, which provide complementary information. Different techniques, such as X-ray crystallography, mass spectrometry, X-ray powder diffraction (XRPD), and nuclear magnetic resonance (NMR) spectroscopy, have been used for the characterization of AuNCs [45,123,162,163]. The structure of some NCs has been resolved experimentally by means of a single crystal X-ray diffraction [123].…”

Section: Toxicity and Clearancementioning

confidence: 99%

Nanotechnology in Tumor Biomarker Detection: The Potential of Liganded Nanoclusters as Nonlinear Optical Contrast Agents for Molecular Diagnostics of Cancer

Combes

Vučković

Bakulić

et al. 2021

Cancers

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Cancer is one of the leading causes of premature death, and, as such, it can be prevented by developing strategies for early and accurate diagnosis. Cancer diagnostics has evolved from the macroscopic detection of malignant tissues to the fine analysis of tumor biomarkers using personalized medicine approaches. Recently, various nanomaterials have been introduced into the molecular diagnostics of cancer. This has resulted in a number of tumor biomarkers that have been detected in vitro and in vivo using nanodevices and corresponding imaging techniques. Atomically precise ligand-protected noble metal quantum nanoclusters represent an interesting class of nanomaterials with a great potential for the detection of tumor biomarkers. They are characterized by high biocompatibility, low toxicity, and suitability for controlled functionalization with moieties specifically recognizing tumor biomarkers. Their non-linear optical properties are of particular importance as they enable the visualization of nanocluster-labeled tumor biomarkers using non-linear optical techniques such as two-photon-excited fluorescence and second harmonic generation. This article reviews liganded nanoclusters among the different nanomaterials used for molecular cancer diagnosis and the relevance of this new class of nanomaterials as non-linear optical probe and contrast agents.

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The emergence of mass spectrometry for characterizing nanomaterials. Atomically precise nanoclusters and beyond

Abstract: Mass spectrometry (MS) is widely used in molecular science, and is now emerging as a characterization technique for ultra-small nanoparticles. In the field of atomically precise nanoclusters, MS combined to...

Cited by 30 publications

References 248 publications

Virus-like Particles: Fundamentals and Biomedical Applications

Virus-like Particles: Fundamentals and Biomedical Applications

Facile one-pot synthesis of white emitting gold nanocluster solutions composed of red, green and blue emitters

Nanotechnology in Tumor Biomarker Detection: The Potential of Liganded Nanoclusters as Nonlinear Optical Contrast Agents for Molecular Diagnostics of Cancer

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