On-line isotope dilution and sample dilution by flow injection and inductively coupled plasma mass spectrometry

Viczián, Miklós; Lásztity, Alexandra; Wang, Xioaru; Barnes, Ramon M.

doi:10.1039/ja9900500125

Cited by 41 publications

(13 citation statements)

References 12 publications

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“…FIA techniques have been coupled to flame atomic absorption spectrometry (FAAS) [15][16][17], inductively coupled plasma atomic emission spectrometry (ICP-AES) [18,19], and ICP-MS [18,19] to achieve on-line dilution. Until now, few workers have attempted to apply this approach to ICP-MS multielement analysis.…”

Section: Introductionmentioning

confidence: 99%

Use of FIA systems for on-line dilution in multielement determination by ICP-MS

Neto

Silva

Souza

et al. 1999

Lab. Robotics Autom.

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A flow-injection (FI) system to match concentrations was used as an auto-diluter in multielement determination by inductively coupled plasma-mass spectrometry (ICP-MS). The flow system comprised loop-based injection or a timed valve that introduced a variable sample volume into a spray chamber through a standard Meinhard nebulizer of an ICP-MS. Routinely analyzed samples such as water, plant, and steel were selected. The accuracy of multielement determination was checked against water standard reference material linear plot with good precision [relative standard deviation (RSD) Ͻ 3%, n ‫ס‬ 12]. The results were in agreement at a 95% confidence level with the certified values for the reference materials and also with those obtained by continuous aspiration and by (FI) with a discrete volume.

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Section: Introductionmentioning

confidence: 99%

Use of FIA systems for on-line dilution in multielement determination by ICP-MS

Neto

Silva

Souza

et al. 1999

Lab. Robotics Autom.

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“…The multiple injection modes produced transient signals in the spiked samples, covering a wide analyte concentration range. 2,3 This application emphasized the effect of nebulizer flow rate, measurement period and dwell times, along transient signals for isotope ratio (IR) measurements. 3 Klinkenberg et al 22 presented in 1993 a simplified flow scheme to perform time controlled injection of discrete volumes of sample or calibration standard into a continuous flowing isotopic enriched solution.…”

Section: Features For Online Addition Of Enriched Isotope Solutionmentioning

confidence: 99%

“…2,3 This application emphasized the effect of nebulizer flow rate, measurement period and dwell times, along transient signals for isotope ratio (IR) measurements. 3 Klinkenberg et al 22 presented in 1993 a simplified flow scheme to perform time controlled injection of discrete volumes of sample or calibration standard into a continuous flowing isotopic enriched solution. By taking into account the corrections for detector dead time and mass discrimination, the spike composition and concentration were adjusted to provide good precision of IR measurements.…”

Section: Features For Online Addition Of Enriched Isotope Solutionmentioning

confidence: 99%

“…2,3 The online ID was performed by continuously pumping sample and spike solutions through separated streams merged in a T-device before reaching the ICP-MS nebulizer. FI and other continuous flow systems have been largely used for online ICP-IDMS (Table 1).…”

Section: Features For Online Addition Of Enriched Isotope Solutionmentioning

confidence: 99%

“…1 in different applications. 2,3 The most common proposal to perform online FI-ID applications involves the introduction of both, sample and isotopic enriched spike, in different channels and the continuous merging of both in a T-junction before introduction into the plasma. The ICP-MS equipments are able to measure at least two isotopes free from interferences for many elements.…”

Section: Introductionmentioning

confidence: 99%

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Online isotope dilution and inductively coupled plasma mass spectrometry: from elemental to species quantification

Giné¹,

Packer²

2010

J. Braz. Chem. Soc.

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Apresentam-se sistemas de análises em fluxo propostos para a quantificação de elementos e espécies por diluição isotópica (ID) utilizando espectrometria de massas com fonte de plasma acoplada indutivamente (ICP-MS). Detalham-se os esquemas para adicionar em linha a solução isotopicamente enriquecida à amostra. São relatadas as aplicações em meio aquoso e outras com transferência do analito para a fase vapor, seja por processo de vaporização eletrotérmica, geração de vapor ou ablação por laser. Apresentam-se as aplicações com quantificação de espécies por ID caracterizadas pela adição do isótopo enriquecido, antes ou após a separação das espécies, seja por cromatografia a líquido, a gás ou por eletroforese capilar acoplada a ICP-MS. As principais equações envolvidas na quantificação por ID e as principais fontes de erro são descritas. São discutidas as mudanças introduzidas na estratégia de quantificação temporal por ID de elementos e espécies pela calibração do fluxo de massas da amostra e do isótopo enriquecido adicionado.Flow analysis has been utilized for elemental and species quantification by online isotope dilution inductively coupled plasma mass spectrometry (ICP-MS). Online isotope dilution (ID) herein refers to strategies promoting the addition of enriched isotopic solutions to the samples while flowing towards the plasma. Applications of online ID's are commonly performed in aqueous media, however, in some processes the analyte transference to the vapor phase using electrothermal vaporization, vapor generation or laser ablation is also required. Flow diagrams to perform online pre or post-column spiking with the enriched isotope for quantification by ID in speciation analysis by liquid chromatography, gas chromatography or capillary electrophoresis devices coupled to ICP-MS are presented. The main figures of merit and equations applied to elemental and species quantification by ID in flowing schemes are assessed.

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Flow Injection Analysis Techniques in Atomic Spectroscopy

Pereiro

Sanz‐Medel

2000

Encyclopedia of Analytical Chemistry

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Flow injection analysis (FIA), developed originally for the automation of serial assays, has become a powerful tool most adequate for performing on‐line any sample preparations before final measurement (e.g. sample dissolution, dilutions, matrix removal, preconcentration, etc.). It is not surprising that the combination of FIA with atomic spectrometric techniques has enlarged the analytical potential of atomic methods and expanded their wide field of applications. The collection of sample manipulation processes which can be covered today by flow operation procedures is amazing and therefore the general instrumentation required is reviewed in this contribution. The description of the different flow strategies is carried out according to a hierarchy going from simple dilutions (including isotopic dilution of particular interest when using mass spectrometric detection), reagent mixing or standard additions, to more sophisticated flow manifolds such as those based on the use of two phases (e.g. gas–liquid, liquid–liquid or solid–liquid) for separation/preconcentration purposes. Modern approaches allowing for on‐line decomposition/dissolution of solid samples (e.g. on‐line chemical oxidation, photo‐oxidation and microwave heating) are also described. Finally, manifolds for the in situ uptake of the sample and its complete on‐line pretreatment are discussed. The coupling of the above flow methodologies to a variety of atomization/excitation/ionization sources (flames, quartz tubes, graphite furnaces, inductively coupled plasmas (ICPs), microwave coupled plasmas, glow discharges (GDs), etc.) is detailed, in order to understand the usefulness of this combination both in atomic techniques based on photon measurements (absorption, emission and fluorescence spectrometry techniques) and on ions measurement mass spectrometry (MS).

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On-line isotope dilution and sample dilution by flow injection and inductively coupled plasma mass spectrometry

Cited by 41 publications

References 12 publications

Use of FIA systems for on-line dilution in multielement determination by ICP-MS

Use of FIA systems for on-line dilution in multielement determination by ICP-MS

Online isotope dilution and inductively coupled plasma mass spectrometry: from elemental to species quantification

Flow Injection Analysis Techniques in Atomic Spectroscopy

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