Ocular Drug Delivery System Using Open-Source Syringe Pump

Abstract

Objective: The objective of this study is to design an automated ocular drug delivery system controlled by an open-source syringe pump, which in turn is to be controlled using Arduino UNO.Methods: The Arduino UNO is the microcontroller used to control the entire setup. The drug delivery is executed using the open-source syringe pump. A 12V NEMA 17 stepper motor is used to execute the pump movements. To facilitate the ease of use, an Android application developed using Android Studio has been developed, where inputs are given in the form of the required drug dose. The application plays the role of converting the requested drug dose into the number of steps required to run the stepper motor. The stepper motor works based on simple lead-screw mechanism.Results: The designed syringe pump has been tested using water. It was determined that for 42 steps a drug volume of 30 μl is dispensed by the designed device. Typically, a drop volume ranges from 33.8 μl to 63.4 μl and the device that has been discussed in this article can deliver a minimum volume of 30 μl.Conclusion: Using this device, excessive use of drugs can be minimalized, thus reducing the capital investment put behind ocular drugs.

Open Source 3D Printed ISO 8655 Compliant Multichannel Pipette

“…These systems have been adapted to do multiple volumes [66] and even large volumes [67,68] for extrusionbased additive manufacturing systems. In addition, multi-syringe systems have been built [61,69] and open source syringe pumps have been demonstrated for high precision applications like occular drug delivery [70]. The development of the open source multichannel pipette system shown here can be coupled to the existing work on syringe pumps to drive the main piston.…”

A control system on the syringe pump based on Arduino for electrospinning application

“…The error value in the form of the coefficient of variation (CV) for the flow rate of 12 ml h -1 is 4.83%. [15][16][17] Figure 6: The linearity testing of the syringe pump for (a) 0.6 ml h -1 , (b) 6 ml h -1 , and (c) 12 ml h -1 .…”