Ocular alterations in dogs naturally infected by Leishmania (Leishmania) chagasi

Brito, Fábio Luiz da Cunha; Alves, Lêucio Câmara; Maia, Frederico Celso Lyra; Santos, E.S.C.; Laus, José Luiz; Meunier, I.M.J.

doi:10.1590/s0102-09352006000500011

Cited by 16 publications

(44 citation statements)

References 11 publications

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“…These animals play a central role in the transmission cycle to humans by phlebotomine sand flies. As also observed in the Old World (Ciaramella et al, 1997), symptomatic cases of CVL due to L. chagasi, in America, presents clinically with anemia, emaciation, splenomegaly, local or generalized lymphadenopathy, cutaneous lesions, ocular lesions (Brito et al, 2006) weight loss, and cachexia. In the present study, dermatological entities previously described by Ferrer (1988), Ciaramella et al (1997) and Lima et al (2004) were observed.…”

Section: Discussionmentioning

confidence: 57%

Hepatic granulomas in canine visceral leishmaniasis and clinical status

Sant'Ana¹,

Lima²,

Oliveira

et al. 2007

Arq. Bras. Med. Vet. Zootec.

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The histopathological description of intralobular hepatic granulomas in animals with a defined clinical status (asymptomatic, oligosymptomatic and symptomatic animals) was reported. Seventy-one mongrel dogs naturally infected with Leishmania chagasi were obtained from two Brazilian endemic areas: João Pessoa, PB and Belo Horizonte, MG. The hepatic parasite load was determined and compared to granuloma formation. Liver fragments from all infected animals showed remarkable leishmaniotic granulomatous inflammatory reaction. Granulomas with variable size were constituted by macrophages (parasitized or not with amastigotes of L. chagasi), some epithelioid cells, small numbers of lymphocytes, plasma cells, and rare neutrophils. Asymptomatic dogs had higher numbers of granulomas than oligosymptomatic and symptomatic animals from both geographical regions. However, the average diametric size of granulomas was very heterogeneous in all groups, independently of the geographic region (P>0.05). Parasite tissue load did not show any difference among liver fragments of all animals, especially when considering the defined clinical status and/or their geographic origin.

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Section: Discussionmentioning

confidence: 57%

Hepatic granulomas in canine visceral leishmaniasis and clinical status

Sant'Ana¹,

Lima²,

Oliveira

et al. 2007

Arq. Bras. Med. Vet. Zootec.

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“…Estes sinais, além da uveíte, quemose e glaucoma secundário, também foram observados em cães portadores de Leishmania chagasi (BRITO et al, 2006). Tais achados possivelmente estão relacionados a uma infecção secundária ocasionada pela imunossupressão ocorrida na leishmaniose (SCHAER;YOUNG, 1985).…”

Section: Resultsunclassified

“…(DIAS et al, 2011). Trabalhos demostram a presença de alterações oftálmicas em animais com leishmaniose, sendo mais frequente a uveíte e a conjuntivite (BRITO et al, 2006).…”

Section: R E S U M Ounclassified

Presença de Leishmania spp. na conjuntiva de um cão não reativo para testes parasitológicos em linfonodos e medula óssea – relato de caso

et al. 2017

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Presença de Leishmania spp. na conjuntiva de um cão não reativo para testes parasitológicos em linfonodos e medula óssea -relato de casoPresence of Leishmania spp. in the conjunctive of a nonreactive dog for parasitological tests in lymphonod and bone marrow -case report A B S T R A C TThe objective of this work was to report the detection of amastigote forms of Leishmania spp.through conjunctival cytology in a non-positive dog for parasitological tests in bone marrow, popliteal lymph nodes and right and left superficial cervicals. A female dog a was attended to with a history of skin problems and dry cough was seen five years ago. After clinical evaluation were performed a cytology of bone marrow, popliteal lymph nodes and superficial cervical, being these negative for parasites. Therefore, new cytological samples were collected in the right and left palpebral conjunctival regions, with the presence of amastigotes of Leishmania spp. It is still unclear to scholars how the amastigote forms of this parasite reach into the ocular tissues, although some of them believe that the parasites are carried by the antigen-presenting cells. It was concluded that conjunctival cytology was a complementary method of diagnosis of leishmaniasis in a non-reactive dog for direct parasitological examination in the medullary and lymph node sites. . Universidade Federal de Campina Grande R E S U M OObjetivou-se com este trabalho relatar a detecção de formas amastigotas de Leishmania spp. através de citologia conjuntival em um cão não positivo para testes parasitológicos em medula óssea, linfonodos poplíteos e cervicais superficial direito e esquerdo. Foi atendida uma cadela com histórico de problemas de pele e tosse seca há cinco anos. Após avaliação clínica, realizouse citologia de medula óssea, linfonodos poplíteos e cervicais superficiais, sendo estes negativos para parasitas. Diante disso, coletou-se novas amostras citológicas na região de conjuntiva palpebral direita e esquerda, sendo nestas observadas formas amastigotas de Leishmania spp. Ainda é uma incógnita para os estudiosos como as formas amastigotas desse parasita chegam aos tecidos oculares, embora alguns deles acreditem que os parasitas são transportados pelas células apresentadoras de antígeno. Conclui-se que a citologia conjuntival foi um método complementar de diagnóstico de leishmaniose em um cão não reativo para exame parasitológico direto em sítio medular e de linfonodo. K E Y W O R D SOphthalmology. Leishmaniasis. Cytology. Conjunctivitis.

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“…Due to the diversity of clinical presentation; the disease may be difficult to diagnosis. Ocular alterations have been reported in some studies, as being common in dogs infected by Leishmania infantum and L. chagasi, such as uveitis and conjunctivitis (Peña et al, 2000;Brito et al, 2006). The ophthalmic form of this disease involving the cornea is less frequent, unless other ocular structures be involved (Roze, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Dogs affected by visceral leishmaniasis usually develop the systemic form of the disease showing a great range of clinical signs (Noli, 1999). Ocular manifestations have been described in canine leishmaniasis affecting over 50% of the infected animals (Brito et al, 2006). Canine calazar affects mostly the anterior segment of the eye (Puchol ad Gonzalez, 1989).…”

Section: Introductionmentioning

confidence: 99%