Occupational photocontact dermatitis from Olaquindox

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

“…Furthermore, OLAQ has been reported to cause allergy [36] and photoallergy in man [37][38]. Symptoms of OLAQinduced photoallergy resemble those of QUIN [31].…”

Airborne allergic contact dermatitis from olaquindox in a rabbit breeder

“…In the case reported, diagnosis of occupational airborne allergic contact dermatitis from olaquindox is supported by distribution of lesions, positive patch test, normal phototest and negative photopatch test, and clearance of cutaneous lesions after withdrawing olaquindox. All reports of photosensitivity or contact sensitivity to olaquindox are occupational (3–7). To our knowledge, no similar case has been described, and allergic contact dermatitis caused by olaquindox is unusual (3), photoallergic contact dermatitis being the more usual event (4, 5), also often airborne and commonly followed by a persistent light reaction (6, 7).…”

Photoallergy

“…Involvement of these shaded areas suggests dermatitis from an airborne allergen or irritant, although in severe and/or chronic cases, these areas may also become involved (32,53). An airborne allergen may also be a photosensitizer, examples of such cases are airborne PACD from crushed chlorpromazine tablets and occupational exposure to olaquindox (a veterinary antibiotic, no longer used in Europe) (5,9,54,55). In clinical evaluation, obtaining a detailed history of environmental exposures and medications with attention to details is essential because, sometimes, the source of exposure to allergen is not so obvious, and allergens may be transferred from one body part to another (ectopic) or from one person to another (connubial).…”