Airborne allergic contact dermatitis from olaquindox in a rabbit breeder

Sánchez‐Pérez, Javier; López, Marta Pascual; García‐Diez, Amaro

doi:10.1034/j.1600-0536.2002.460316.x

Cited by 10 publications

(1 citation statement)

References 7 publications

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“…Concern has long been expressed over their use as carbadox is genotoxic and carcinogenic in experimental animals, while olaquindox is genotoxic although it has not been shown to be carcinogenic (Sykora & Vortel, 1986;Woodward, 2004). Olaquindox has been reported to cause allergic and photoallergic dermatitis in farm workers, largely in those involved with pigs, following occupational exposure (Bedello et al, 1985;Francalanci et al, 1986;Schauder, 1989;de Vries et al, 1990a,b;Hochsattel et al, 1991;Fewings & Horton, 1995;Kumar & Freeman, 1996;Schauder et al, 1996;Sanchez-Pedreno et al, 2001;Belhadjali et al, 2002;Sanchez-Perez et al, 2002). Their phototoxic potentials have also been demonstrated in animal models (de Vries et al, 1990a,b;Eberlein et al, 1992).…”

Section: Antimicrobial Drugsmentioning

confidence: 99%

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Woodward¹

2005

Vet Pharm & Therapeutics

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Although seemingly rare, adverse reactions to veterinary products do occur. These may arise from inadvertent exposure during use or as a result of occupational accidents. They are often mild in nature and include adverse effects such as minor skin reactions. However, more serious reactions may occur, and they are not restricted to the effects of the veterinary medicines themselves. For example, high-pressure injection injuries may occur as a result of accidents occurring during animal vaccination operations. This paper reviews some of these events, mentions where appropriate the regulatory actions taken, and describes some of the measures used to minimise such effects in the future, and serves to bring the issues discussed here to the attention of pharmacologists, pharmacoepidemiologists and others who train those who use veterinary medicinal products.

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Section: Antimicrobial Drugsmentioning

confidence: 99%

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Woodward¹

2005

Vet Pharm & Therapeutics

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Adverse Reactions in Humans Following Exposure to Veterinary Drugs

Woodward¹

2009

Veterinary Pharmacovigilance

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A highly sensitive and specific polyclonal antibody-based enzyme-linked immunosorbent assay for detection of antibiotic olaquindox in animal feed samples

Zhao

et al. 2008

Anal Bioanal Chem

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The use of olaquindox (OLA) as an additive in animal feedstuffs has been prohibited in the European Union and many other countries. In this study, a highly sensitive and specific indirect competitive enzyme-linked immunosorbent assay (ELISA) for determination of OLA in animal feed samples was developed. OLA was activated by N'N-carbonyldiimidazole and coupled with bovine serum albumin (BSA) and ovalbumin (OVA). It was found that the sensitivity and specificity of the two antisera were very similar, with the IC(50) values of 16 ng mL(-1) and 19 ng mL(-1), respectively. Cross-reactivity was less than 35% for four structurally related compounds and no recognition of five other antibiotics was observed. The better antiserum I was selected for further experiments, for example testing stability, solvent effect, accuracy, and precision. The IC(50) value for eight standard curves was in the range 12-18 ng mL(-1) and the LOD at a signal-to-noise ratio of 3 (S/N = 3) was 0.31 +/- 0.11 ng mL(-1). The ELISA tolerated 5% methanol without significant influence on IC(50) value. The recoveries of spiked OLA in five different animal feed types including auxin, pig complex feed, fish complex feed, broiler concentrated feed, and pig premix feed were in the range 88.3-119.0% and the intra-assay relative standard deviation (RSD) was within 4.7-33.5% (n = 3). The ELISA for unspiked feed samples was confirmed by high-performance liquid chromatography (HPLC), with a high correlation coefficient of 0.9862 (n = 5). The proposed ELISA could be a feasible quantitative/screening method for OLA analysis in feed samples with the properties of high sensitivity, specificity, simplicity of sample pretreatment, high sample throughput, and low expense.

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Airborne allergic contact dermatitis from olaquindox in a rabbit breeder

Cited by 10 publications

References 7 publications

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Adverse Reactions in Humans Following Exposure to Veterinary Drugs

A highly sensitive and specific polyclonal antibody-based enzyme-linked immunosorbent assay for detection of antibiotic olaquindox in animal feed samples

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