Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Abstract

Although seemingly rare, adverse reactions to veterinary products do occur. These may arise from inadvertent exposure during use or as a result of occupational accidents. They are often mild in nature and include adverse effects such as minor skin reactions. However, more serious reactions may occur, and they are not restricted to the effects of the veterinary medicines themselves. For example, high-pressure injection injuries may occur as a result of accidents occurring during animal vaccination operations. This paper reviews some of these events, mentions where appropriate the regulatory actions taken, and describes some of the measures used to minimise such effects in the future, and serves to bring the issues discussed here to the attention of pharmacologists, pharmacoepidemiologists and others who train those who use veterinary medicinal products.

Adverse reactions in a population of Sydney pet rabbits vaccinated against rabbit calicivirus

“…Adverse reactions were categorised using the revised ABON system, 15,16 as probable (A), possible (B), unlikely to be product related (N), inconclusive (O1) or unclassifiable (O). This system is widely used, including by the manufacturers of vaccines, to comment on the likelihood of a vaccination event causing an adverse event.…”

“…This system is widely used, including by the manufacturers of vaccines, to comment on the likelihood of a vaccination event causing an adverse event. 15,16 To be assigned a classification of probable (A), the adverse event must (1) occur within a reasonable time post vaccination, 2) be consistent with previous clinical or pathological reports or be reasonable given the pharmacology and toxicology of the vaccine and (3) not have another equally plausible explanation. 16 If these three criteria were not met, the adverse reaction was assigned to B, N, O1 or O category.…”

“…15,16 To be assigned a classification of probable (A), the adverse event must (1) occur within a reasonable time post vaccination, 2) be consistent with previous clinical or pathological reports or be reasonable given the pharmacology and toxicology of the vaccine and (3) not have another equally plausible explanation. 16 If these three criteria were not met, the adverse reaction was assigned to B, N, O1 or O category. The possible (B) category was assigned when the vaccination event was one of other plausible causes of the adverse reaction but inclusion criteria for (A) were not met.…”

“…11 These local reactions are expected, because of the oil-based nature of the vaccine, and this has been reported to occur with similar products in other species. [12][13][14] The other presentation involves systemic signs such as anorexia, paralysis, diarrhoea, lethargy, reproduction disorders and death. 11 Anaphylaxis is a reported rarely, with only one report from 1995 to 2010.…”

Effect of Different Conservation Conditions on the Active Compounds and Pharmacovigilance Screening of Different Florfenicol Preparations

“…Veterinary pharmacovigilance is a study of discipline which searches whether it is about taking drugs as a result of the adverse affects of the usage of veterinary medical drugs or not and also searches the degree of this. Following the veterinary medical drugs after marketing includes evaluating and preventing the probable adverse affects on animals which are treated and the effects on human health and environment at the same time 1,7,10 . Veterinary pharmacovigilance involves great scope.…”