Nutritive evaluation and effect of Moringa oleifera Lam on clastogenic potential in the mouse

Anticlastogenic Effect of Eryngium foetidum L. Assessed by Erythrocyte Micronucleus Assay

“…The in vivo rodent micronucleus assay has been accepted as a short-term assay for evaluation of the clastogenicity of chemical compounds as well as the anticlastogenicity of chemopreventive potential of compounds (Ashby et al, 1988;Heo et al, 1996;Kupradinun et al, 1997Kupradinun et al, : 2008Hwang et al, 2008;Promkum et al, 2010). Mouse peripheral blood, instead of bone marrow cells, was introduced to use in the micronucleus assay (MacGregor et al, 1980) and recently, acridine orange was used for supravital staining of blood cells (Hayashi et al, 1983).…”

Health Benefits of Moringa oleifera

“…In recent years, there has been a new interest in the clastogenicity and anti-clastogenicity of Moringa oleifera . The results from a study by Promkum et al (2010) showed that bMO did not possess any clastogenic activity in mice upon consuming a diet consisting of 1.5%, 3.0% and 6.0% bMO. The Moringa oleifera demonstrated free radical scavenging properties that directly indicate anti-clastogenic effects which was found to be due to its rich vitamin C content.…”

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

“…A single dose (150 mg/kg body weight) of methanolic extract of M. oleifera leaves protected bone marrow against chromosomal alterations (aberrations, metaphasic chromosome breaks and micronucleus formation) in mice exposed to gamma irradiation, allowing regeneration of hematopoietic stem cells and increasing survival of the animals [63]. This anticlastogenic effect was also seen in animals treated for 14 consecutive days with a diet enriched with increasing percentage of pods (cooked and pre-frozen), decreasing the number of micronucleated peripheral erythrocytes induced by mitomycin C exposure [64].…”

“…Abortifacient Leaves, roots [113], [114] Against Plasmodium falciparum and Schistosoma mansoni cercariae Seeds [105], [106] Analgesic Roots [27], [84] Antiatherosclerotic Leaves [69] Anticlastogenic Leaves, pods [63], [64] Anti-constipant Flowers [109] Anticonvulsant Leaves, roots [27], [103], [104] Antiespasmodic Leaves, seeds [80] Antihelminthic Seeds [53] Anti-inflammatory Seeds, leaves, roots [80], [81], [82], [83] Antioxidant Leaves, seeds [24], [25], [26], [63], [67], [68], [70] Antipyretic Leaves [18] Antitumor Seeds, stem, leaves [68], [72], [87], [88] Antiulcerogenic Leaves, seeds [65], [66] Bactericidal Leaves, stem, pods [17], [93], [97], [94], [95], [96] Bradycardic/Hipotensive Seeds [77], [78], [79] Diuretic Seeds [80] Fungicide Leaves, seeds [91], …”

“…The antimutagenic activity evidenced by micronucleus formation attenuation [63,64] may be a factor involved in deferring carcinoma progression. Hence, antioxidants like β-carotene and glycyrrhetic acid might be very effective in combating cancer.…”