Anticlastogenic Effect of Eryngium foetidum L. Assessed by Erythrocyte Micronucleus Assay

Promkum, Chadamas; Butryee, Chaniphun; Tuntipopipat, Siriporn; Kupradinun, Piengchai

doi:10.7314/apjcp.2012.13.7.3343

Cited by 21 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The micronucleated cells were scored under a fluorescence microscope. 1000 peripheral reticulocytes per mouse were analyzed, and the frequencies of micronucleated peripheral reticulocytes were scored in three slides per animal [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass)

Padilla-Camberos

Martínez-Velázquez

Flores-Fernández

et al. 2013

The Scientific World Journal

View full text Add to dashboard Cite

The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract of Persea americana was evaluated with respect to its genotoxic potential through micronucleus assay in rodents. The frequency of micronuclei in groups of animals treated with avocado seed extract showed no differences compared to the negative control (vehicle); therefore, it is considered that the avocado seed extract showed no genotoxic activity in the micronucleus test.

show abstract

Section: Methodsmentioning

confidence: 99%

Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass)

Padilla-Camberos

Martínez-Velázquez

Flores-Fernández

et al. 2013

The Scientific World Journal

View full text Add to dashboard Cite

show abstract

“…The study using ICR mice that mice were fed AIN-76 semipurified diet supplemented with ground freeze dried EF at 0.8%, 1.6% and 3.2% for 2 weeks. The results shown no clastogenic effect and mice were treated with diets mixwell with EF decreased the number of micronucleated peripheral reticulocytes in all the MMC-treated groups in a dose dependent manner (10). Briefly, edible parts of EF was cleaned with tap and deionized water, drained and air dried, slightly crushed to small pieces, quick freezed with liquid nitrogen, then lyophilized, ground, packed and stored at −20°C until analysis.…”

Section: Methodsmentioning

confidence: 99%

“…EF also exhibited the highest inhibitory activity against MCF-7 human mammary carcinoma cell (9). Recently, it was reported that EF had anti-clastogenic activity in mouse erythrocyte (10). However, consumption at high dose for long term and its toxic effect have never been reported.…”

Section: Introductionmentioning

confidence: 99%

A 24-Weeks Toxicity Study ofEryngium foetidumLinn. Leaves in Mice

et al. 2016

Self Cite

View full text Add to dashboard Cite

Eryngium foetidum Linn. leaves (EF) are widely used in Thailand and many countries throughout Asia as a culinary seasoning and a traditional medicine. However, adverse effect of high dose consumption in long duration has not been evaluated. The aim of this study was to investigate chronic toxicity of EF in mice. Thirty-two ICR male mice were divided into 4 groups of 8 mice each. The mice were fed AIN-76 rodent diet, or AIN-76 rodent diet supplemented with ground freeze-dried EF at 0.8%, 1.6% and 3.2% that is equivalent to approximately 35, 73 and 155 times that of human consumption, respectively, at 97.5 percentile for a period of 24 weeks. At the end of experiment, the mice were euthanized and blood samples were collected for hematological and biochemical evaluations. Necropsy was performed while visceral organs such as lung, liver, kidneys, spleen etc. were collected, weighed and histopathologically examined. Blood urea nitrogen (BUN) results of mice in 1.6% and 3.2% EF diet groups were significantly higher than the BUN of control group. No significant difference was noted in other biochemical and hematological properties between the treatment groups and control; all results were within normal range. Histopathology of almost all visceral organs showed no significant changes. However, tubulonephrosis and chronic interstitial nephritis were observed in the groups treated with 1.6% and 3.2% EF diet. Body weight was reduced significantly at week 12 to week 20 when compared to the control group while relative kidney weights were significantly increased. In conclusion, the consumption of EF in diet at high doses illustrated the adverse effect on some biochemical parameters and histopathology in mice. Our findings suggested that EF daily consumption for 24 weeks, at higher doses than the 0.8% EF diet (35 times of human consumption), might cause adverse effect on kidney function in mice.

show abstract

“…Leaves and branches of the plant are rationally used to garnish and flavoring foods as a substitute for coriander due to similar aroma and fragrance [2]. E. foetidum also has several pharmaceutical applications such as anticlastogenic [3], antiinflammatory [4], anthelmintic and anticarcinogenic properties [1]. Leaves of this underutilized herb contain the essential oil eryngial (0.29%, trans-2-dodecenal) have many industrial applications [5].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiling of spiny coriander (Eryngium foetidum L.) – A potential perennial spicing-culinary herb of eastern India

Acharya

Ponnam

Kumari

et al. 2021

AChrom

View full text Add to dashboard Cite

Spiny coriander (Eryngium foetidum L.) is a perennial medicinal herb grown in the tropical regions worldwide. In India, it is used as a potential spice for garnishing and flavoring the dishes and treating several ailments. Eryngium spp. found in coastal Odisha, India has a strong aroma similar to the seasonal Coriandrum. The volatile flavor constituents of the unique plants were analyzed through headspace solid-phase microextraction (HS-SPME) using capillary gas chromatography (GC) and gas chromatography-tandem mass spectrometry (GC–MS/MS). The volatile compounds exhibited high chemodiversity, with 10-undecenal as the major component in leaves (44.98%) and branches (57.43%). Fourier-transform infrared (FTIR) spectroscopy identified eight major peaks grouped into six main regions. Chemo profiles of these two corianders were overlapped and showed similar area differences in the spectral peak. The lesser-known perennial Eryngium with high chemodiversity would be a better alternative to the seasonal coriander for aromatic, pharmaceutical, and industrial uses.

show abstract

Anticlastogenic Effect of Eryngium foetidum L. Assessed by Erythrocyte Micronucleus Assay

Cited by 21 publications

References 25 publications

Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass)

Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass)

A 24-Weeks Toxicity Study ofEryngium foetidumLinn. Leaves in Mice

Phytochemical profiling of spiny coriander (Eryngium foetidum L.) – A potential perennial spicing-culinary herb of eastern India

Contact Info

Product

Resources

About