Nutritional assessment methods for zinc supplementation in prepubertal non-zinc-deficient children

Lopes, Márcia Marília Gomes Dantas; Brito, Naira Josele Neves de; Rocha, Érika Dantas de Medeiros; França, Mardone Cavalcante; Almeida, Maria das Graças; Brandão-Neto, José

doi:10.3402/fnr.v59.29733

Cited by 11 publications

(6 citation statements)

References 49 publications

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“…Giving a dose of 5 mg for 2 weeks at under 2 years significantly zinc plasma levels better than placebo [25]. Giving a dose of 10 mg/day for 3 months in children showed that there was a significant increase in serum zinc in the intervention group [26].…”

Section: Discussionmentioning

confidence: 91%

The Effect of Biscuits Made From Pumpkin Seeds Flour on Serum Zinc Levels and Weight in Malnutrition Wistar Rats

Syam¹,

Burhan²,

Hadju³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Serum zinc levels are found to be low in children of protein energy malnutrition globally. Pumpkin seed flour has a high zinc content of 6.88 mg/100 g, has been formulated biscuits made from pumpkin seed flour with a zinc content of 1.52 mg/100 g. AIM: This study aims to determine the effect of giving biscuits made from pumpkin seed flour to serum zinc levels and body weight in malnutrition Wistar rats. METHODS: This research is a true experiment with pre-post-test with control group design. Subjects were 28 male Wistar strain rats induced by fasting malnutrition for 3 days and then given biscuits with a zinc dose of 0.027 mg; 0.054 mg; and 0.081 mg/BW/day and in the control group without biscuits for 2 weeks. Serum zinc levels were examined using the atomic absorption spectrophotometry method. Data were analyzed using paired t-test and one-way ANOVA test. RESULTS: Paired t-test results on serum zinc levels obtained p > 0.05 and on body weight obtained p < 0.05. One-way ANOVA test results on serum zinc levels after the intervention obtained p > 0.05 and at body weight obtained p < 0.05 followed by post hoc least significant difference test found that there were significant differences between the control group and the P1 group, a dose of 0.027 mg (p = 0.015) and P2 groups, doses of 0.054 mg (p = 0.012). Greater weight gain was found in the P1 group with an increase of 38.85%. CONCLUSION: The provision of biscuits made from pumpkin seed flour has an effect on increasing body weight of malnutrition Wistar rats and has no effect on serum zinc levels, so further research is expected to use different doses.

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Section: Discussionmentioning

confidence: 91%

The Effect of Biscuits Made From Pumpkin Seeds Flour on Serum Zinc Levels and Weight in Malnutrition Wistar Rats

Syam¹,

Burhan²,

Hadju³

et al. 2020

Open Access Maced J Med Sci

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“…The PA is an indicator of change in the integrity of cell membranes and the intercellular space (23). Lopes et al (24) reported a mean PA of 5.0° in the healthy population. In our study, we observed lower values of 3.0° and 2.4° for G1 and G2, respectively.…”

Section: Discussionmentioning

confidence: 97%

Bioelectrical impedance vector analysis and phase angle in boys with Duchenne muscular dystrophy

Vermeulen

Lopes

Grilo

et al. 2019

Food & Nutrition Research

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Background Duchenne muscular dystrophy (DMD) is a disease characterized by progressive loss of functional muscle mass followed by changes in body composition. Objective This study aimed to describe and evaluate bioimpedance parameters in boys with DMD. Design This cross-sectional, descriptive study investigated children and adolescents diagnosed with DMD. Age, weight, height, resistance, and reactance data were collected. Phase angle and bioelectrical impedance vector analysis were calculated based on resistance and reactance values. Results We analyzed 43 boys aged between 2.7 and 19.8 years. Low-phase angle values were observed during the investigation of bioimpedance parameters. Bioelectrical impedance vector analysis showed that approximately 87% of the subjects presented vectors outside the tolerance ellipses, and only one patient presented vectors located within the 50% tolerance ellipse, indicating normally hydrated and a good body cell mass. Compared with the reference population, boys with DMD had lower levels of body cell mass. Conclusion Based on the evidence, compared with the reference population, patients with DMD had lower levels of body cell mass. This evidence points to bioimpedance parameters as useful tools for the nutritional evaluation and clinical management of patients with DMD.

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“…Zn-NPs also affect molecular signaling pathways and stimulate both different metabolic effects in distinct organisms [53] and innate immune systems [54]. Zinc has also been shown to improve both weight and height development in humans [55]. Therefore, Zn-NPs favored a growth increase.…”

Section: Discussionmentioning

confidence: 99%

Novel Polymeric Nanocarriers Reduced Zinc and Doxycycline Toxicity in the Nematode Caenorhabditis elegans

et al. 2019

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The objective was to evaluate the toxicity of zinc- and doxycycline-loaded polymeric nanoparticles (NPs) using Caenorhabditis elegans as a model organism. These NPs are composed of ethylene glycol dimethacrylate, 2-hydroxyethyl methacrylate and methacrylic acid. NPs were loaded with doxycycline (D-NPs) and zinc (Zn-NPs) by chemical adsorption, and loading efficacy was demonstrated. Worm death rate in a concentration-response curve basis was calculated for lethality. Metabolism was evaluated through pharyngeal pumping assay. Body length measurements, brood size and egg lays were used to gauge growth, reproduction and fertility respectively. Intracellular hydrogen peroxide levels were determined to assess the reactive oxygen species production. One-way ANOVA and Bonferroni were used for comparisons (p < 0.05). Tested NPs at the highest dosage did not affect lethality or worm metabolism, expressed in terms of death rate and pharyngeal pumping per minute, respectively. Zn-NPs slightly increased worm growth. The concentration of the intracellular hydrogen peroxide levels was the lowest in the D-NPs group. The distinct NPs and concentrations employed were shown to be non-toxic for in situ administration of zinc and doxycycline, reducing the harmful effects of these compounds.

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Nutritional assessment methods for zinc supplementation in prepubertal non-zinc-deficient children

Cited by 11 publications

References 49 publications

The Effect of Biscuits Made From Pumpkin Seeds Flour on Serum Zinc Levels and Weight in Malnutrition Wistar Rats

The Effect of Biscuits Made From Pumpkin Seeds Flour on Serum Zinc Levels and Weight in Malnutrition Wistar Rats

Bioelectrical impedance vector analysis and phase angle in boys with Duchenne muscular dystrophy

Novel Polymeric Nanocarriers Reduced Zinc and Doxycycline Toxicity in the Nematode Caenorhabditis elegans

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