Bioelectrical impedance vector analysis and phase angle in boys with Duchenne muscular dystrophy

Abstract

Background Duchenne muscular dystrophy (DMD) is a disease characterized by progressive loss of functional muscle mass followed by changes in body composition. Objective This study aimed to describe and evaluate bioimpedance parameters in boys with DMD. Design This cross-sectional, descriptive study investigated children and adolescents diagnosed with DMD. Age, weight, height, resistance, and reactance data were collected. Phase angle and bioelectrical impedance vector analysis were calculated based on resistance and reactance values. Results We analyzed 43 boys aged between 2.7 and 19.8 years. Low-phase angle values were observed during the investigation of bioimpedance parameters. Bioelectrical impedance vector analysis showed that approximately 87% of the subjects presented vectors outside the tolerance ellipses, and only one patient presented vectors located within the 50% tolerance ellipse, indicating normally hydrated and a good body cell mass. Compared with the reference population, boys with DMD had lower levels of body cell mass. Conclusion Based on the evidence, compared with the reference population, patients with DMD had lower levels of body cell mass. This evidence points to bioimpedance parameters as useful tools for the nutritional evaluation and clinical management of patients with DMD.

Predicational ability of phase angle on protein energy wasting in kidney disease patients with renal replacement therapy: A cross‐sectional study

“…Bioelectrical impedance analysis is a simple, noninvasive, and reliable technique for estimation of body composition and has been used in the diagnosis of diseases such as Type 2 diabetes, muscle dysfunction, hydration, and nutritional assessment (Dittmar et al., 2015; Norman et al., 2012; Vermeulen, Lopes, Grilo et al., 2019). In CKD patients, malnutrition has been widely recognized and the manifested is PEW.…”

“…In As'habi's cross-sectional study, the prevalence of PEW in peritoneal dialysis patients was 29% (As'Habi et al, 2019). In Lydia Namuyimbwa's study, PEW prevalence was 47.3% in the CKD subjects and significantly higher than those without CKD (21.3%; Vermeulen, Lopes, Grilo, et al, 2019). Since the dominate prevalence of PEW has great impact on the quality of life and treatments of CKD, the early diagnosis and intervention would benefit the health situation and reduce the medical cost and burden (Chao et al, 2017).…”

Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy

“…DMD boys had lower levels of body cell mass and hydration compared with the healthy population described in the literature. This evidence points to bioimpedance parameters as useful tools for the nutritional evaluation of patients with DMD [ 10 ].…”

When age matters: boys with Duchenne muscular dystrophy have growth delay and a fat mass accumulation, as they get older

“…Besides, Caromano et al (Caromano et al, 2010) noticed that body fat accumulation is also influenced by a sedentary lifestyle and may not reflect weight change due to loss of lean mass. The intense muscular atrophy causes this loss as a consequence of the disease (Vermeulen et al, 2019).…”