Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

Abstract

In recent years, nutraceuticals have gained great popularity, owing to their physiological and potential health effects, such as anti-inflammatory, anti-cancer, antioxidant, and prebiotic effects, and their regulation of lipid metabolism. Since the Mediterranean diet is a nutritionally recommended dietary pattern including high-level consumption of nutraceuticals, this review aimed to summarize the main results obtained by our in vitro and in vivo studies on the effects of the major constituents of the Mediterranean diet (i.e., extra virgin olive oil compounds, polyunsaturated fatty acids, and fruit components). Based on experimental studies, the therapeutic purpose of nutraceuticals depends on their bioavailability, solubility, toxicity, and delivery system. This review provides more in-depth knowledge on the effects linked to nutraceuticals administration on human health, focusing the gastrointestinal tract and suggesting specific dietary components for personalized adjuvant therapies.

The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms

“…Then, due to endothelium anti-inflammatory and anticoagulant properties of silibinin and its capability to interact with SARS-CoV-2 main target proteins demonstrated herein, silibinin could be a strong candidate for COVID-19 management from a multitarget perspective. molecular docking experiments Phytochemicals from the medicinal plants Docking analysis molecular docking experiments Patel, Goswami, Sivakumar, Pandya [20] Phytochemicals from the medicinal plants molecular docking and molecular dynamics (MD) simulations silymarin lead to possessing the ability to interact and mask the amino acids of RBD, making them unavailable to form associations with ACE2. Such a molecule is termed as ‘fusion inhibitor’.…”

“…Consequently, they might play a protective role against COVID-19-associated complications [18] . In this regard, polyphenol and flavonoid compounds' anti-inflammatory and antioxidant activity have been confirmed strongly [19] , [20] . Silymarin is a complex polyphenolic compound derived from the seed of the milk thistle plant, and it is known for its anti-inflammatory, antiviral, anti-oxidative, and immunomodulatory effects [21] , [22] , [23] .…”

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

“…The evolution of the nutraceutical industry can be recognized as it has now reached disease prevention after it started from health promotion. A plethora of currently used herbs and phytochemicals are safe pharmacologically and have been proven to be potent nutraceuticals in suppressing tumor progression, alleviating the disadvantages of radio- and chemotherapy and increasing the sensitivity of these therapies [ 89 , 90 ]. Caponio and his team evaluated the effects of the phenolic compounds found in Aglianico Grape pomace (GP) on colorectal cancer cell lines at varying stages of development after subjecting them to an in vitro digesting model.…”

Consumption of Hen Eggs Enriched with n-3 Polyunsaturated Fatty Acids, Selenium, Vitamin E and Lutein Incites Anti-Inflammatory Conditions in Young, Healthy Participants — A Randomized Study

“…Functional foods, indistinguishable from conventional foods, are considered to be somewhat enhanced foods that exert therapeutic benefits for human health beyond their nutri-tive values due to enrichment with bioactive components [11]. Nevertheless, a complete definition is still not fully explained/accepted as well as there is no legal or regulatory status assigned [11][12][13][14]. So-called nutraceuticals, from "nutrition" and "pharmaceutical", are described as products derived from food sources that exert certain preventive and therapeutic characteristics in terms of antioxidant and antiinflammatory action [12][13][14][15].…”