A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

Puri, Vivek; Nagpal, Manju; Singh, Inderbir; Singh, Manjinder; Dhingra, Gitika Arora; Huanbutta, Kampanart; Dheer, Divya; Sharma, Ameya; Sangnim, Tanikan

doi:10.3390/nu14214637

Cited by 49 publications

(16 citation statements)

References 188 publications

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“…In addition, the half-life of vitamin E in the brain is much longer than in other organs, which suggests the presence of specialized processes that regulate the central nervous system ( Meganathan and Fu, 2016 ). Furthermore, the concentrations of vitamin E vary across various areas of the brain ( Puri et al, 2022 ). Therefore, in the present study, the combination of vitamin E and RES was more beneficial than a high dosage of RES alone.…”

Section: Discussionmentioning

confidence: 99%

Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer’s disease in rats: Mechanistic approach to prevent inflammation

Foudah

Devi²,

Alam³

et al. 2023

Front. Pharmacol.

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The most common form of dementia, Alzheimer’s disease (AD), is characterized by gradual declines in cognitive abilities and behavior. It is caused by a combination of factors, including amyloid-β (Aβ) accumulation, acetylcholine (ACh) loss, oxidative stress, and inflammation. Phenolic compounds have a variety of health benefits, including antioxidant activities. Thus, the purpose of this study was to investigate how resveratrol (RES) alone and in combination with vitamin E affected rats with AD using scopolamine (SCO). Animals are categorized into groups; (i) control, (ii) SCO (1 mg/kg i.p.), (iii) SCO + donepezil, (iv) SCO + RES (50 mg/kg, p.o.), (v) SCO + RES (75 mg/kg, p.o.), (vi) SCO + RES (50 mg/kg + vitamin E 1 mg/kg, p.o.) for 17 days. In rats, studied behavioural (NOR and EPM) and biochemical characteristics. In addition, brain histopathology was examined to investigate any damage to the hippocampus and neuroprotection. SCO-induced changes in acetylcholinesterase, protein carbonyl, and TNF-α improved after resveratrol treatment. RES increased antioxidant levels, decreased SCO-induced lipid peroxidation, and reversed SCO-mediated changes compared with the drug donepezil. The results indicated that RES and vitamin E had nootropic action in the NOR and EPM tests, measured by the recognition index and the inflection ratio. This study supports the efficacy of RES as a preventive and treatment agent for AD. Vitamin E showed a synergistic effect on RES, which helps in managing cognitive impairment AD.

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Section: Discussionmentioning

confidence: 99%

Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer’s disease in rats: Mechanistic approach to prevent inflammation

Foudah

Devi²,

Alam³

et al. 2023

Front. Pharmacol.

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“…[3][4][5] Plant extracts are used in developing nourishing and biologically active nutraceuticals and most especially, phenolic rich extracts are the most important in this domain. [6,7] Nutraceutical is a term derived from "nutrition" and "pharmaceutical" and signifies a range of dietary supplements, plant products, beverages, cereals, and other processed foods that are beneficial in nutrition and medicine. [8,9] Nutraceuticals originate from plant or animals and much research is now focusing on their development, efficacy, safety and clinical trials but not intended to replace pharmaceuticals and rather helps in preventing certain pathological conditions, chronic and long-term diseases.…”

Section: Introductionmentioning

confidence: 99%

HPLC-DAD Phenolic Composition, Antioxidant, Anticholinesterase, Antidiabetic and Anti-quorum Sensing Properties of Bitter Kola (Garcinia kola) and Kolanut (Cola acuminata)

Boudiba¹,

Küçükaydın²,

Tamfu³

et al. 2023

Pharmacogn. Res.

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Background: Eating Cola acuminata and Garcinia cola nuts in African societies symbolizes in socio-cultural hospitality. They stimulate the nervous system, reduce fatigue and sleep. Objectives: To determine the phenolic composition and bioactivities of G. kola and C. acuminata. Materials and Methods: Hydro-ethanol extracts of the nuts were prepared and their phenolic profiles determined using HPLC-DAD. Antioxidant, anticholinesterase, antidiabetic, antimicrobial, antibiofilm and anti-quorum sensing properties were determined. Results: The most abundant phenolic compound was caffeic acid (105.4±0.75 mg/g) in C. acuminata and myricetin (277.2±0.90 mg/g) in G. kola. The extracts showed good antioxidant activity in five complementary assays and G. kola was more active than both α-tocopherol and BHA standards in the DPPH • , CUPRAC and ABTS •+ assays while C. acuminata was more active than only the α-tocopherol standard in the same assays. Activities were close to those of standards in the β-Carotene-linoleic acid and metal chelation assays. Both extracts had good inhibition of Butyrylcholinesterase (BChE) and Acetylcholinesterase (AChE) with IC 50 values 63.27±0.98 µg/mL and 94.15±1.05 µg/mL for C. acuminata and G. kola respectively compared to 5.50±0.25 µg/mL for galantamine in the AChE assay. In the BChE assay, the inhibitory activity was higher for G. kola (IC 50 = 38.66±0.80 µg/ mL) that the standard galantamine (IC 50 = 42.20±0.48 µg/mL) while that for C. acuminata (IC 50 = 87.31±0.77 µg/mL) was moderate. The extracts inhibited α-amylase and α-glucosidase with G. kola (IC 50 =18.43±0.74 µg/mL) being more active than standard acarbose (IC 50 =20.52±0.84 µg/mL in the α-glucosidase assay. The nuts could inhibit expression of virulence factors in Chomobacterium violaceum CV12472 by disrupting violacein production and flagellated Pseudomonas aeruginosa PA01 by disrupting swarming motility. Conclusion: The results indicate good nutraceutical potential of both nuts.

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“…As products that are intended to meet specific diets and preventive health care, nutraceuticals are characterized as “specially designed formulations”. They achieves the purpose of preventing and treating certain diseases while supplementing the daily diet [ 3 ]. As consumers’ awareness of healthy living increases, people are gradually avoiding the use of products that contain chemical additives because of the possible risks such as cancer and allergies [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Properties of Kakadu Plum-Blended Products

et al. 2023

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Kakadu plum (Terminalia ferdinandiana), endemic to Australia, is growing in popularity due to its high levels of vitamin C and strong antioxidant properties. In this study, Kakadu plum fruit powder was used as a functional food ingredient with other plant materials to develop value-added products to enhance their nutritional and commercial value. The present study determined the bioactive properties of nine products, including three Kakadu plum fruit powder samples produced from different processing batches and five Kakadu plum-blended products. Vitamin C, the total phenolic content, and the ellagic acid content were determined. Bioactive properties such as antioxidant, antidiabetic, and antimicrobial assays were also performed. Cytotoxicity was tested to obtain more specific product information regarding food safety. Kakadu plum-blended products showed lower cytotoxicity and lower bioactive properties (antioxidant and antibacterial activities) in comparison to Kakadu plum powder. However, overall, most of the bioactive properties were shown to be higher in the blends when compared with the commercial blueberry powder as a benchmark antioxidant product. Therefore, there is great potential for Kakadu plum to contribute to the growing functional food and ingredient markets.

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A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

Cited by 49 publications

References 188 publications

Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer’s disease in rats: Mechanistic approach to prevent inflammation

Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer’s disease in rats: Mechanistic approach to prevent inflammation

HPLC-DAD Phenolic Composition, Antioxidant, Anticholinesterase, Antidiabetic and Anti-quorum Sensing Properties of Bitter Kola (Garcinia kola) and Kolanut (Cola acuminata)

Bioactive Properties of Kakadu Plum-Blended Products

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