Nutraceuticals and Food Additives

Moldes, Ana Belén; Vecino, Xanel; Cruz, J.M.

doi:10.1016/b978-0-444-63666-9.00006-6

Cited by 35 publications

(18 citation statements)

References 83 publications

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“…Thus, over the last few years, there has been an increased scientific interest in finding distinct bioactive peptide sequences that can reduce or prevent the risk of chronic diseases and provide immune protection [ 2 ]. Thus, the use of bioactive peptides has gained much interest as nutraceuticals [ 10 ] and functional foods [ 11 ]. As a result, much research has been dedicated recently to the processing and generation of bioactive peptides from food products, and the previously under-utilized protein-rich by-products of the food industries [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

2018

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Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment.

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Section: Introductionmentioning

confidence: 99%

Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

2018

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“…Food additives are used in food industry in small quantities to improve the color, flavor, taste, appearance and texture of food (Moldes et al, 2017). Monosodium glutamate (MSG) is a common glutamic acid salt containing 78% glutamic acid, 22% sodium salt and water.…”

Section: Introductionmentioning

confidence: 99%

Monosodium glutamate (MSG):promoter of neurotoxicity, testicular impairment, inflammation and apoptosis in male rats

Abdou¹,

Hassan²

2020

Swed J BioSci Res

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Monosodium glutamate (MSG) is one of the most common food additives extensively used as a flavor enhancer. MSG induced lipid peroxidation and inflammation. The present study aimed to assess the neurotoxicity, testicular impairment, inflammation and apoptosis induced by MSG. Thirty adult male Wistar rats, weighing about 180-200 g were assigned equally into five groups, each consists of six rats. Animals of Group I are controls and they received distilled water, whereas animals of Groups II, III, IV and V were given oral daily doses of MSG 0.8, 1, 2 and 3 g/kg body weight, respectively for consecutive 70 days. Administration of different doses of MSG revealed a significant elevation in the levels of malondialdehyde (MDA), nitric oxide (NO), β amyloid 1-42, proinflammatory cytokines (IL-6, TNF-α), cholesterol and sperm abnormality while it showed reduction in the level of GSH and SOD, CAT and GST antioxidant enzymes activities, sperm count and sperm motility. MSG led to disruption in neurotransmitter levels; serotonin, norepinephrine, glutamate and GABA, also disorders in sexual hormones; testosterone, FSH and LH. The present results were confirmed by histological and immunohistochemical observations that obviously designate the neurodegeneration and reproductive toxicity. In conclusion, administration of low and high doses of MSG provoke deleterious effects on oxidant/ antioxidant markers, neurotransmitters, inflammatory cytokines, sexual hormones, brain and testes structures. Prominence hazards of lasting exposure to low and high doses of MSG on neuronal and testicular health. Therefore, its use should be restricted.

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“…BP-rich hydrolysates, obtained from different legume plants, such as chickpea, soy bean, pea, lentil, mung bean have been studied and characterized for their antimicrobial and antihypertensive activities (Ariza-Ortega et al, 2014; Maestri et al, 2016). Either as purified forms or mixtures, BP have been proposed for the treatment and prevention of various medical conditions due to their cholesterol-lowering effects, antiprotozoal, antiviral, antithrombotic, antioxidant, antihypertensive, and antimicrobial activities (Lemes et al, 2016), and were extensively characterized as nutraceuticals (Moldes et al, 2017) and functional foods (Haque et al, 2008). BP are becoming popular in the skin and hair care field too, as they possess a wide range of biological activities in skin cells and are capable of triggering signal transduction mechanisms, leading to the activation of important gene regulators.…”

Section: Bioactive Peptides In Animals and Plantsmentioning

confidence: 99%

Plant and Microalgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics

Apone¹,

Barbulova²,

Colucci³

2019

Front. Plant Sci.

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Bioactive peptides (BP) are specific protein fragments that are physiologically important for most living organisms. It is proven that in humans they are involved in a wide range of therapeutic activities as antihypertensive, antioxidant, anti-tumoral, anti-proliferative, hypocholesterolemic, and anti-inflammatory. In plants, BP are involved in the defense response, as well as in the cellular signaling and the development regulation. Most of the peptides used as ingredients in health-promoting foods, dietary supplements, pharmaceutical, and cosmeceutical preparations are obtained by chemical synthesis or by partial digestion of animal proteins. This makes them not fully accepted by the consumers because of the risks associated with solvent contamination or the use of animal derived substances. On the other hand, plant and microalgae derived peptides are known to be selective, effective, safe, and well tolerated once consumed, thus they have got a great potential for use in functional foods, drugs, and cosmetic products. In fact, the interest in the plant and microalgae derived BP is rapidly increasing and in this review, we highlight and discuss the current knowledge about their studies and applications in the cosmetic field.

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Nutraceuticals and Food Additives

Cited by 35 publications

References 83 publications

Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

Monosodium glutamate (MSG):promoter of neurotoxicity, testicular impairment, inflammation and apoptosis in male rats

Plant and Microalgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics

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