Monosodium glutamate (MSG):promoter of neurotoxicity, testicular impairment, inflammation and apoptosis in male rats

Abdou, Heba M.; Hassan, Ekram M.

doi:10.51136/sjbsr.2020.78.90

Cited by 5 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rats were randomly allocated into five groups (six rats each) as follows: Group 1: this group received normal laboratory diet, tap water ad libitum and given saline daily during the time of experiment. Group 2: this group fed HFHFD for 12 weeks and given saline daily during the time of experiment. Group 3: this group fed HFHFD for 12 weeks and omega‐3 oil (260 mg/kg) for the last 4 weeks Group 4: this group fed HFHFD for 12 weeks and metformin (100 mg/kg) for the last 4 weeks …”

Section: Methodsmentioning

confidence: 99%

Improvement of insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats treated with omega‐3 fatty acid orl‐carnitine

Zayed

Ain-Shoka

Shazly

et al. 2018

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Background Frequent consumption of fructose and saturated fatty acids increase risk of metabolic syndrome (MS). Features of MS include insulin resistance, dyslipidemia, visceral obesity, and hypertension. The aim of this study was to investigate the role of omega‐3 and l‐carnitine in ameliorating features of MS. Methods MS was induced in rats by high‐fructose high‐fat fed diet for 8 weeks. They were randomly divided into five groups: normal control, MS control group treated with saline, MS groups given omega‐3 (260 mg/kg), l‐carnitine (200 mg/kg), or metformin (100 mg/kg) daily for 4 weeks. Body weight, relative organ weight, glucose, insulin, adiponectin, and lipid profiles were estimated. Also glucose transporter 4 (GLUT4) content and peroxisome proliferator‐activated receptor‐gamma (PPARγ) protein expressions were determined. Results Omega‐3 and l‐carnitine caused decrease in both MS‐induced increase in body weight and glucose similar to metformin. They reduced insulin level and resistance with increased adiponectin, and correction of MS‐induced hyperlipidemia. Drugs also increased GLUT4 and PPARγ protein expression compared with MS control group. Conclusion Omega‐3 and l‐carnitine improve features of MS via increased GLUT4 and PPARγ expression.

show abstract

Section: Methodsmentioning

confidence: 99%

Improvement of insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats treated with omega‐3 fatty acid orl‐carnitine

Zayed

Ain-Shoka

Shazly

et al. 2018

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…Cardiovascular diseases, due to their prevalence, as well as a prominent place in the structure of mortality, are a significant medical and social problem [1,9]. Cerebral stroke ranks 5th among the causes of death and is the leading cause of disability [26].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the important role of monosodium glutamate in the development of certain pathological conditions, its influence on the structure and function of the vascular bed, in particular the carotid arteries and the carotid sinus, has not been sufficiently studied. However, the role of monosodium glutamate in the development of obesity and hypertension [25], Alzheimer's disease [13], abnormalities in the development of the nervous system [1] and gastric erosions [8] is described in the scientific literature. The relationship between monosodium glutamate consumption and manifestations of toxic effects in tissues of lymph nodes [15], colon [16], liver [6] and reproductive system [20] was also shown.…”

Section: Introductionmentioning

confidence: 99%

Morphometric assessment of the effects of monosodium glutamate on the carotid sinus wall: an experimental study

Sodomora

2023

Rep. of Morph.

View full text Add to dashboard Cite

The increase in global burden of stroke is hard to overestimate. Every year it continues to be a leading cause of mortality worldwide. Extracranial pathology of the carotid arteries is a major underlying reason of stroke. Given the role of alimentary factors in the development of atherosclerosis of the carotid arteries, possible influence of food additives on the carotid sinus structure is of special interest. Monosodium glutamate is one of the most common food additives that is allowed for consumption in many countries due to it being considered relatively safe. Recent scientific research however points towards the possible adverse effects of monosodium glutamate on the living organism. The aim of this study was to analyze qualitative and quantitative parameters of carotid sinus structural organization of white male albino rats under normal conditions, in the setting of oral monosodium glutamate consumption and after its withdrawal. Carotid sinuses of 30 white male albino rats that had been daily consuming 10 mg/kg of monosodium glutamate for 4 or 8 weeks with subsequent withdrawal for 2 weeks were subjected to qualitative and quantitative analysis at different time-points of the experiment. The data obtained was compared with the results of morphologic and morphometric study of carotid sinuses of 9 rats of the control group. For morphometric analysis, the following parameters were considered: intima thickness, media thickness, adventitia thickness, diameters of the arterioles, venules and capillaries of the carotid sinus vasa vasorum. Summarizing the morphometric analysis results, it is worth noting that, for the duration of 8 weeks of the experiment, steady increase in the thickness of all layers of the vascular wall, but especially intima and adventitia, was observed in the study group. At the same time, the diameter of the arterioles located in the carotid sinus adventitia was decreasing, while venules and capillaries demonstrated invariable increase of their lumen diameter. After 2 weeks of monosodium glutamate withdrawal, the thickness of intima and adventitia continued to increase, while media thickness had somewhat decreased, probably due to fibrosis and dystrophy. The tendency towards narrowing of the arterioles’ lumen and widening of the venules and capillaries persisted for at least 2 weeks despite discontinuation of monosodium glutamate. Therefore, systematic consumption of monosodium glutamate may lead to impairment of carotid sinus structural organization, particularly endothelial proliferation, fibrotic and dystrophic changes of media, adventitia thickening as well as microcirculatory vessels damage, that continue to persist despite the food additive withdrawal.

show abstract

“…Despite numerous studies reporting the harmful effects of monosodium glutamate on the living organism [1], its use continues to be widespread and sometimes uncontrolled due to the fact that the presence of the additive E621 is often not even recorded on food packaging. The monosodium salt of glutamic acid is also present in baby food products.…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress is considered one of the important pathogenetic aspects of sodium glutamate's influence on a living organism [6,7]. An important role is also played by the development of inflammation and fibrosis [7], metabolic disorders [3,18] and DNA damage -the so-called genotoxic effect [1,10]. Numerous studies have reported adverse effects of monosodium glutamate on the heart [3] and vessels, including the aorta [3] and thoracic arteries [13], as well as other organs [4].…”

Section: Introductionmentioning

confidence: 99%

Structural organization of the carotid sinus under the influence of monosodium glutamate in the experiment: analysis of changes in dynamics

Sodomora

2022

Rep. of Morph.

View full text Add to dashboard Cite

Carotid artery pathology is one of the leading causes of cerebral stroke. Among the pathogenetic factors in the development of carotid artery damage, disorders of lipid metabolism, atherosclerosis, and metabolic syndrome occupy a prominent place. The alimentary factor is extremely important in this context. Monosodium glutamate is one of the most common food additives, which is often used uncontrollably and can cause changes in the structure and functions of organs and tissues. The purpose of the study: to analyze the dynamics of morphological changes in the carotid sinus area under the influence of monosodium glutamate when administered orally in an experiment. The area of the carotid sinus of 20 male laboratory white rats that received sodium glutamate orally at a dose of 10 mg/kg/day for 8 weeks was studied by morphological methods at the macro- and microstructural levels after 6 and 8 weeks of the experiment. The obtained data are compared with the results of a morphological study of the same area in 20 animals of the control group. Statistical processing of animal weight was performed using MS Excel 2007 software. Mean ± standard deviation was determined. After 6 weeks of the experiment, when evaluating the histological structure of the wall of the internal carotid artery in the area located directly above the bifurcation, when compared with the control group, multiplication and folding of the intima were found in the experimental group, presumably associated with the proliferation of endothelial cells under the influence of sodium glutamate, detachment of the endothelium and lysis of individual endotheliocytes, as well as uneven thickening of elastic media fibers and disruption of their structure. Attention was drawn to the accumulation of white fat perivasally and in the zone of the carotid glomus, as well as the disorganization of nerves and the expansion of vessels of the microcirculatory channel. After 8 weeks of the experiment, the negative dynamics of structural changes were noticeable: signs of increased inflammatory infiltration, deformation of the vessels of the microcirculatory bed with thickening of their walls and narrowing of the lumen, stasis, noticeable degranulation of cells of type I carotid glomus cells, the appearance of single labrocytes (mast cells) in the infiltrate. The amount of adipose tissue (white fat) in the area of the carotid sinus and the perivasal bifurcation of the carotid arteries, as well as in the immediate vicinity of the carotid glomus, also increased markedly, and a tendency towards thickening of adipose tissue was noted. Thus, monosodium glutamate with systematic oral use can cause a violation of the structural organization of the carotid sinus, the wall of the carotid arteries and the carotid glomus, and the severity of changes in dynamics increases. Further research is needed to clarify the nature of the structural changes in the carotid sinus under the conditions of withdrawal of monosodium glutamate, as well as to find possible ways of correction.

show abstract

Monosodium glutamate (MSG):promoter of neurotoxicity, testicular impairment, inflammation and apoptosis in male rats

Cited by 5 publications

References 15 publications

Improvement of insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats treated with omega‐3 fatty acid orl‐carnitine

Improvement of insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats treated with omega‐3 fatty acid orl‐carnitine

Morphometric assessment of the effects of monosodium glutamate on the carotid sinus wall: an experimental study

Structural organization of the carotid sinus under the influence of monosodium glutamate in the experiment: analysis of changes in dynamics

Contact Info

Product

Resources

About