Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

Abstract

Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment.

Comparison of the hypoglycemic and antithrombotic (anticoagulant) actions of whole bovine and camel milk in streptozotocin-induced diabetes mellitus in rats

“…Furthermore, these food-derived natural peptides, with few side effects and readily absorbed from the gastrointestinal tract, could be of commercial interest. It is no surprise that they are attracting a great deal of attention from the pharmaceutical and the health-promoting functional food industries (Chakrabarti et al, 2018).…”

Dipeptidyl Peptidase IV (DPP-IV) Inhibitory Activity of Ultrafiltration and Gel Filtration Fraction of Gelatin Hydrolyaste Derived from Bone of Fish for Antidiabetes

“…Diprotin A and B, a microbial bioactive peptide provide supreme inhibitory activity toward DPP-IV [10], regardless the utilization of food based protein as parent of bioactive peptide is a favorable choice, paticularly for safety and health consideration. The food based protein that have been used to produce of bioactive peptide covering chiken egg, beef meat, soy protein, cheese, milk, corn, fish meat and gelatin [1], [4], [11]. We definitely agreed that gelatin is the most promosing source of bioactive peptide including for DPP-IV inhibitor.…”

“…Bioactive peptides is specific protein fragments (usually range from 2 to 20 amino acid residues) that acting as sources of amino acids sequence with numerous potential physiological functions including opioid, antioxidant, immunomodulatory, antibacterial, antithrombotic and antihypertensive activity [1]. Now, it has been investigated largerly for other biofunctional properties, such as anticancer [2] and antidiabetes [3].…”

Prediction of the Health Effects of Food Peptides and Elucidation of the Mode‐of‐action Using Multi‐task Graph Convolutional Neural Network

“…It is well known that milk, meat, and plants contain bioactive peptides. [9] Bioactive food peptides can be a lead compound for the development of new drugs and functional foods. [8] However, the mode-ofaction of bioactive food peptides has not been well understood, and their potential health effects remain to be identified.…”

“…[8] However, the mode-ofaction of bioactive food peptides has not been well understood, and their potential health effects remain to be identified. [9] Bioactive food peptides can be a lead compound for the development of new drugs and functional foods. Food peptides have been well studied, but most previous studies have been based on in vitro and in vivo approaches.…”