Nucleotides and Intestine

Tsujinaka, Toshimasa; Kishibuchi, Masanori; Iijima, Shöhei; Yano, Masahiko; Monden, Morito

doi:10.1177/014860719902300519

Cited by 23 publications

(17 citation statements)

References 11 publications

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“…In addition, dietary nucleotides also stimulate cell differentiation (Sanderson & He, 1994) and dietary supplementation with nucleic acid stimulates mucosal cell proliferation (Kishibuchi et al, 1997;Tsujinaka et al, 1999). The development of the gastrointestinal tract directly affects the digestion and absorption of nutrients and, consequently, animal performance.…”

Section: Resultsmentioning

confidence: 99%

Effect of plasma and/or yeast extract on performance and intestinal morphology of piglets from 7 to 63 days of age

Rigueira¹,

Thomaz

Rigueira

et al. 2013

R. Bras. Zootec.

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-The objective of this study was to evaluate the effect of diets supplemented with plasma and/or yeast extract on performance (daily weight gain [DWG], daily feed intake [DFI] and feed conversion [FC]) and intestinal morphology of piglets from 7 to 63 days of age. A total of 288 piglets aged 7 days and weighing 2.57±0.05 kg were studied. A randomized block design consisting of four experimental diets, six repetitions and 12 piglets per experimental unit was adopted. The prestarter I (7 to 21 days), pre-starter II (22 to 35 days) and starter I (36 to 49 days) diets were supplemented as follows: control diet (CD): no plasma or yeast extract; plasma (PL) diet: addition of 6%, 4% and 2% plasma; yeast extract (YE) diet: addition of 6%, 4% and 2% yeast extract; plasma + yeast extract (PL+YE) diet: addition of 3%, 2% and 1% plasma and yeast extract each. From 50 to 63 days of age all piglets received the same diet. No difference in performance was observed from 7 to 21 days and from 7 to 28 days of age, whereas DWG was higher from 7 to 35 days in piglets receiving the PL+YE diet (268, 278, 271 and 288 g/day for CD, PL, YE and PL+YE, respectively). From 7 to 49 days and from 7 to 63 days, DWG (330 and 519 g/day, respectively) and DFI (307 and 647 g/day) were higher in animals receiving the PL-YE diet when compared with those consuming CD (DWG: 295 and 486 g/day; DFI: 266 and 594 g/day). No significant differences in intestinal morphology were observed between piglets receiving the different diets. The combination of plasma and yeast extract elevates DWG, but does not affect the intestinal morphology of piglets from 7 to 63 days of age.

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Section: Resultsmentioning

confidence: 99%

Effect of plasma and/or yeast extract on performance and intestinal morphology of piglets from 7 to 63 days of age

Rigueira¹,

Thomaz

Rigueira

et al. 2013

R. Bras. Zootec.

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“…Moreover, intestinal homeostasis may depend on exogenous supplies of NTs because the de novo NT synthesis seems to be limited. Therefore, NTs can be considered as "semi-essential" nutrients, especially during periods of starvation, injury or stress [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Exogenous nucleosides modulate expression and activity of transcription factors in Caco-2 cells

Ortega

Gil

Sánchez–Pozo

2011

The Journal of Nutritional Biochemistry

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“…A suplementação com ácido nucléico estimula a proliferação das células da mucosa (KISHIBUCHI et al, 1997;TSUJINAKA et al, 1999 …”

Section: Nucleotídeosunclassified

Adição de glutamina e nucleotídeos em rações para suínos na creche

Carrazza¹,

Sant’ana²,

Alves³

et al. 2011

Pubvet

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ResumoA suinocultura, caracterizada como uma atividade competitiva e bastante dinâmica, constantemente gera esforços no sentido de melhorar a produtividade e reduzir custos de produção. Dentro da atividade, o setor de creche é visto como uma das fases mais importantes e que gera maiores preocupações, pois nessa etapa vários fatores como, separação da mãe e mudança da dieta geram alterações comportamentais e físicas, que comprometem o desempenho dos animais. Entre os métodos utilizados para corrigir deficiências nutricionais, e melhorar a capacidade digestiva e imune dos animais, está a utilização de aditivos alimentares dentre eles a glutamina e fontes de nucleotídeos. Desde modo, o objetivo desta revisão foi abordar os benefícios da adição de glutamina e nucleotídeos na dieta de suínos na fase de creche.

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Nucleotides and Intestine

Abstract: Parenteral supplementation of nucleic acids supports the mucosal cell proliferation and functions.

Cited by 23 publications

References 11 publications

Effect of plasma and/or yeast extract on performance and intestinal morphology of piglets from 7 to 63 days of age

Effect of plasma and/or yeast extract on performance and intestinal morphology of piglets from 7 to 63 days of age

Exogenous nucleosides modulate expression and activity of transcription factors in Caco-2 cells

Adição de glutamina e nucleotídeos em rações para suínos na creche

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