Novel Treatment of Onychomycosis using Over-the-Counter Mentholated Ointment: A Clinical Case Series

Derby, Richard; Rohal, Patrick; Jackson, Constance; Beutler, Anthony I.; Olsen, Cara

doi:10.3122/jabfm.2011.01.100124

Cited by 42 publications

(30 citation statements)

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“…[42][43][44] Regarding the former, eucalyptus containing Vicks ® VapoRub TM (Proctor & Gamble Co., Cincinnati, OH) was applied to onychomycotic toenails for 48 weeks in an uncontrolled trial. 45 Mycologic and clinical cure was seen in 5 of 15 subjects, and 10 had partial clearance with a variety of fungal etiologies. 45 Three randomized controlled trials of tea tree oil alone for integumentary fungal infections have been reported.…”

Section: Pathophysiologymentioning

confidence: 99%

“…45 Mycologic and clinical cure was seen in 5 of 15 subjects, and 10 had partial clearance with a variety of fungal etiologies. 45 Three randomized controlled trials of tea tree oil alone for integumentary fungal infections have been reported. 44 Satchell et al found a clinical cure after 4 weeks in 68%-72% with 25%-50% tea tree oil (placebo response: 39%) and mycological cure in 55%-64% (placebo response: 31%) of 120 evaluable patients with dermatophyte tinea pedis.…”

Section: Pathophysiologymentioning

confidence: 99%

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Fungal Infections From Human and Animal Contact

Baumgardner

2017

Journal of Patient-Centered Research and Reviews

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Section: Pathophysiologymentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

Fungal Infections From Human and Animal Contact

Baumgardner

2017

Journal of Patient-Centered Research and Reviews

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“…Another treatment option that lacks the side effects of oral antifungal medications is Vicks VapoRub (The Proctor & Gamble Company, Cincinnati, OH) [24]. This treatment has been discussed in the layman literature but, until recently, has never been studied scientifically.…”

Section: Resultsmentioning

confidence: 99%

“…This treatment has been discussed in the layman literature but, until recently, has never been studied scientifically. Numerous ingredients in Vicks VapoRub have been studied in vitro , including thymol, menthol, camphor, and oil of Eucalyptus, and have demonstrated efficacy against dermatophytes [24]. …”

Section: Resultsmentioning

confidence: 99%

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New Concepts in Median Nail Dystrophy, Onychomycosis, and Hand, Foot, and Mouth Disease Nail Pathology

et al. 2012

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Nails are underutilized as diagnostic tools, despite being involved in many dermatologic conditions. This paper explores new concepts in the treatment of median nail dystrophy (MND), onychomycosis, and the nail pathology of hand, foot, and mouth disease (HFMD). A Pubmed database literature search was conducted for MND treatment, onychomycosis treatment, and HFMD nail pathology. Only papers published after January 2008 were reviewed. The results showed that 0.1% tacrolimus ointment can be an effective treatment for MND. Early studies on laser therapy indicate that it is a safe and efficacious treatment option for onychomycosis, compared to conventional oral antifungal agents. Vicks VapoRub (The Proctor & Gamble Company, Cincinnati, OH) is effective against onychomycosis and is a reasonable option in patients who choose to forgo conventional treatments. Lastly, there is evidence to support a correlation between HFMD and onychomadesis.

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Repurposing Medications—Chicken Manure, Erectile Dysfunction, and Finding the Golden Needle in the Haystack of Absurdity

Stratman

2017

JAMA Dermatol

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My dad grew up on a chicken farm. One winter in my youth, while at an extended family gathering in his little farm town in mid-Missouri, I was complaining to him about my severe chapped lips. "Well, farmers around here would tell you to put chicken [manure] on chapped lips. That's a sure cure." Looking around the circle of conversation, I saw several relatives, farmers, and locals affirming this statement. For the next dozen years I was perplexed by the recommendation and silent about any further lip concerns.Fast forward 35 years, and, I suspect like many readers of JAMA Dermatology, I see patients in the dermatology office with outlandish claims of successful therapies. I began my dermatology career trying to listen empathetically, but could only hear Patsy Cline's "Crazy" playing somewhere in the back of my mind. There was no science! There was no evidence! I needed to shepherd these poor patients down the path of reason and scientific validity! After several humbling clinical experiences and review of a tongue-in-cheek publication on the lack of scientific evidence that parachutes reduce the risk of injury when jumping from a plane, 1 I began to soften. I don't practice alternative, holistic, or Eastern medicine, to my knowledge, but I don't bash it either. I don't judge patients' claims too harshly, and I almost never tell them their suggestions definitely won't work. Truthfully, I have recommended the addition of duct tape in my over-the-counter wart treatment regimens, and I have shrugged my shoulders with indifference when patients request to use Vicks VapoRub in the treatment of their elderly onychomycosis. Neither of these products was brought to market to treat these conditions. It was patient experience, belief systems, and word of mouth that often brought about the larger treatment movements, and eventually more rigorous studies. 2,3 In this month's JAMA Dermatology, Ibrahim et al 4 and Albers et al 5 each report a separate small series of patients with severe Hailey-Hailey disease recalcitrant to many conventional therapies who responded remarkably and quickly to lowdose, compounded oral naltrexone. This discovery seems to have its origins in patient word of mouth; specifically through online Hailey-Hailey disease support groups. Where once there was a water cooler or barber shop around which remedy anecdotes were swapped, today's patient is online, connected to large volumes of information and to others with similar con-Opinion EDITORIAL jamadermatology.com (Reprinted)

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Novel Treatment of Onychomycosis using Over-the-Counter Mentholated Ointment: A Clinical Case Series

Cited by 42 publications

References 14 publications

Fungal Infections From Human and Animal Contact

Fungal Infections From Human and Animal Contact

New Concepts in Median Nail Dystrophy, Onychomycosis, and Hand, Foot, and Mouth Disease Nail Pathology

Repurposing Medications—Chicken Manure, Erectile Dysfunction, and Finding the Golden Needle in the Haystack of Absurdity

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