Novel Potentiometric Sensors of Molecular Imprinted Polymers for Specific Binding of Chlormequat

Kamel, Ayman H.; Moreira, Felismina T.C.; Almeida, S.A.A.; Sales, M. Goreti F.

doi:10.1002/elan.200704039

Cited by 58 publications

(31 citation statements)

References 27 publications

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“…Sol-gel membranes were obtained by coating a clean graphite support [25] with 200 μL of the viscous ISG solution. This solution was allowed to dry at room temperature.…”

Section: Preparation Of the Membrane Electrodesmentioning

confidence: 99%

“…Ion exchangers and neutral macrocyclic compounds have been employed with success for this purpose over the past decades. However, the design of new sensing materials that are complementary to the size and charge of a particular ion may lead to very selective interactions [24][25][26]. This could be done by imprinting the target analyte (SDZ and SMX) on a solid surface [27,28].…”

Section: Introductionmentioning

confidence: 99%

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Sulphonamide-imprinted sol–gel materials as ionophores in potentiometric transduction

Almeida

Moreira

Heitor

et al. 2011

Materials Science and Engineering: C

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This work proposes different kind of solid-contact graphite-based electrodes for the selective determination of sulphonamides (SPHs) in pharmaceuticals, biological fluids and aquaculture waters. Sulfadiazine (SDZ) and sulfamethoxazole (SMX) were selected for this purpose for being the most representative compounds of this group. The template molecules were imprinted in sol-gel (ISG) and the resulting material was used as detecting element. This was made by employing it as either a sensing layer or an ionophore of PVC-based mem-branes and subsequent potentiometric transduction, a strategy never reported before. The corresponding non-imprinted sol-gel (NISG) membranes were used as blank. The effect of plasticizer and kind/charge of ionic lipo-philic additive was also studied. The best performance in terms of slope, linearity ranges and signal reproducibility and repeatability was achieved by PVC membranes including a high dielectric constant plasticizer and 15 mg of ISG particles. The corresponding average slope was −51.4 and −52.4 mV/decade, linear responses were 9.0 × 10 −6 and 1.7 × 10 −5 M, and limits of detection were 0.74 and 1.3 μg/mL for SDZ and for SMX, respectively. Good selectivity with log Kpotb−0.3 was observed for carbonate, chloride, fluoride, hydrogenocarbonate, nitrate, nitrite, phosphate, cyanide, sulfate, borate, persulphate, citrate, tartrate, salicylate, tetracycline, ciprofloxacin, sulphamerazine, sulphatiazole, dopamine, glucose, galactose, cysteine and creatinine. The best sensors were successfully applied to the analysis of real samples with relative errors ranging from −6.8 to +3.7%.

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“…Sol-gel membranes were obtained by coating a clean graphite support [25] with 200 μL of the viscous ISG solution. This solution was allowed to dry at room temperature.…”

Section: Preparation Of the Membrane Electrodesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sulphonamide-imprinted sol–gel materials as ionophores in potentiometric transduction

Almeida

Moreira

Heitor

et al. 2011

Materials Science and Engineering: C

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“…The general procedure used to prepare the PVC membrane is similar to works reported by Prasada Rao [19,20], Sales [18], Gupta [30], Al Attas [31,32], Ganjali [33] and Shamsipur [34]. Exactly 60 mg PVC was dissolved in 2.5 mL of THF.…”

Section: Electrode Preparationmentioning

confidence: 99%

“…Among the reported researches in the field of electrochemical methods for β -blockers [12][13][14][15], there are only a few papers that concern directly metoprolol [15] and nearly no article is found that reported for detection of metoprolol using MIP based ion-selective electrode. Generally, it can be mentioned that there are only a few reports dealing with potentiometric molecular sensors based on MIPs [16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer Based PVC-Membrane-Coated graphite electrode for the determination of metoprolol

Tehrani

Vardini

Azar

et al. 2010

JICS

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A PVC membrane based on metoprolol molecularly imprinted polymer (MIP) coated directly on graphite electrode for determination of metoprolol in real sample is described. This potentiometric sensor was designed by dispersing the MIP particles in dioctylphthalate plasticizer as solvent mediator and then embedded in polyvinyl chloride matrix. The electrode exhibits a near Nernstian of 55.4±1 mV decade -1 for metoprolol over a wide concentration range between 2.0×10 -7 -8.0×10 -3 M and a detection limit of 1.26×10 -7 M. It has a response time of about 14 seconds and can be used for at least 6 months without any divergence in potential. The proposed electrode can be used in the pH range of 3.5-10.5 and revealed good selectivities for metoprolol over a wide variety of ions. Finally, the designed sensor was successfully applied as an indicator electrode to determine concentration of metoprolol in tablets, human urine and plasma and the results were compared favorably with those obtained by HPLC method and showed satisfactory agreements with them.

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“…Molecularly imprinted polymers (MIPs) are a route to obtain such materials and have been introduced successfully in polymeric membranes (Kamel et al, 2008;Moreira et al, 2010). They are specifically designed to display stereochemical interactions with the analyte and act similarly to natural antibodies.…”

Section: Introductionmentioning

confidence: 99%

Novel LTCC-potentiometric microfluidic device for biparametric analysis of organic compounds carrying plastic antibodies as ionophores: Application to sulfamethoxazole and trimethoprim

Almeida

Arasa

Puyol

et al. 2011

Biosensors and Bioelectronics

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A B S T R A C TMonitoring organic environmental contaminants is of crucial importance to ensure public health. This requires simple, portable and robust devices to carry out on-site analysis. For this purpose, a low-temperature co-fired ceramics (LTCC) microfluidic potentiometric device (LTCC/µPOT) was developed for the first time for an organic compound: sulfamethoxazole (SMX).Sensory materials relied on newly designed plastic antibodies. Sol-gel, self-assembling monolayer and molecular-imprinting techniques were merged for this purpose. Silica beads were amine-modified and linked to SMX via glutaraldehyde modification. Condensation polymerization was conducted around SMX to fill the vacant spaces. SMX was removed after, leaving behind imprinted sites of complementary shape. The obtained particles were used as ionophores in plasticized PVC membranes. The most suitable membrane composition was selected in steady-state assays. Its suitability to flow analysis was verified in flow-injection studies with regular tubular electrodes.The LTCC/µPOT device integrated a bidimensional mixer, an embedded reference electrode based on Ag/AgCl and an Ag-based contact screenprinted under a micromachined cavity of 600 µm depth. The sensing membranes were deposited over this contact and acted as indicating electrodes.Under optimum conditions, the SMX sensor displayed slopes of about −58.7 mV/decade in a range from 12.7 to 250 µg/mL, providing a detection limit of 3.85 µg/mL and a sampling throughput of 36 samples/h with a reagent consumption of 3.3 mL per sample.The system was adjusted later to multiple analyte detection by including a second potentiomet-ric cell on the LTCC/µPOT device. No additional reference electrode was required. This concept was applied to Trimethoprim (TMP), always administered concomitantly with sulphonamide drugs, and tested in fish-farming waters. The biparametric microanalyzer displayed Nernstian behaviour, with aver-age slopes −54.7 (SMX) and +57.8 (TMP) mV/decade. To demonstrate the microanalyzer capabilities for real applications, it was successfully applied to single and simultaneous determination of SMX and TMP in aquaculture waters.K e y w o r d s

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Novel Potentiometric Sensors of Molecular Imprinted Polymers for Specific Binding of Chlormequat

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Cited by 58 publications

References 27 publications

Sulphonamide-imprinted sol–gel materials as ionophores in potentiometric transduction

Sulphonamide-imprinted sol–gel materials as ionophores in potentiometric transduction

Molecularly imprinted polymer Based PVC-Membrane-Coated graphite electrode for the determination of metoprolol

Novel LTCC-potentiometric microfluidic device for biparametric analysis of organic compounds carrying plastic antibodies as ionophores: Application to sulfamethoxazole and trimethoprim

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