Novel Metformin Carbon Paste and PVC Electrodes

Khaled, Elmorsy; Hassan, H. N. A.; Kamel, Manal S.; Barsoum, Barsoum N.

doi:10.2174/157341207782418776

Cited by 8 publications

(7 citation statements)

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“…The conventional polyvinylchloride (PVC) membrane electrodes have found a wide range of applications in pharmaceutical analysis;5–7 however, they still have certain inherent limitations due to the difficulty of miniaturization and their short lifetime. To overcome the aforementioned difficulties in PVC membrane electrodes, new kinds of all solid‐state ones (without internal reference solution) allowing electrode miniaturization capability were introduced.…”

Section: Introductionmentioning

confidence: 99%

Towards disposable sensors for drug quality control: Dextromethorphan screen‐ printed electrodes

Khaled

Hassan

Mohamed

et al. 2010

Drug Testing and Analysis

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A simple, rapid, reliable, and reproducible method for mass production of disposable sensors using screen-printing technology is described. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrode was used as dextromethorphan (DXM) sensor. The proposed sensors worked satisfactorily in the concentration range from 10⁻⁵ to 10⁻² mol L⁻¹ with detection limit reaching 6 × 10⁻⁶ mol L⁻¹ and adequate shelf life of 8 months. DXM was determined in pharmaceutical formulations under batch and flow injection analysis (FIA) conditions with sampling output 120 h⁻¹.

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Section: Introductionmentioning

confidence: 99%

Towards disposable sensors for drug quality control: Dextromethorphan screen‐ printed electrodes

Khaled

Hassan

Mohamed

et al. 2010

Drug Testing and Analysis

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“…Via incorporation of the sensing membrane with a suitable ion pairing agents following by soaking in GST solution, the GST-ion associates will be precipitated on the membrane/aqueous solution interface which consequently be extracted into the electrode bulk by the plasticizer which act as organic solvent [40][41][42][46][47][48].Thus, there is no need for precipitation of ion pair complex which safe time and chemical consumption. Herein, different types of ion pairing agents were tested including: NaTPB, RNC, KTCPB, PTA and PMA (Fig.…”

Section: Insitu Modification 3121 Nature Of the Modifiermentioning

confidence: 99%

Novel Disposable Potentiometric Sensor for Determination of Granisetron in Surface Water Samples and Pharmaceutical Formulations

El-Attar

Khaled

2021

Egypt. J. Chem.

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Herein, the fabrication and characterization of novel granisetron (GST) disposable screen-printed potentiometric sensors was described. Different fabrication protocols were introduced including; incorporation of different ions of pairing agents or GST-ion associatesas electroactive sensing materials. For sake of simplicity, the dummy blank sensors can be soaked in the GST-ion associates aqueous suspension, where ion associates were extracted within the electrode matrix by the membrane plasticizer. Deep and comprehensive investigations were performed regarding the sensing matrices compositions including the influence of modifier nature and content, plasticizer, and the fabrication protocol. Incorporation of the electrode matrix with SWCNTs improved the sensor performance. Sensors modified with phosphotungstic acid showed Nernstian compliance for the GST concentration range from 10 −6 to 10 −2 mol L −1 , adequate operational shelf lifetime (6 weeks) and fast response time (4s). Moreover, the electrode potential was pH-independent in wide range with improved selectivity. The developed sensors were introduced for GST quantification in surface water samples and pharmaceutical formulations under flow injection analysis (FIA), standard addition and potentiometric titration conditions.

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“…Measurements were carried out by system consists of double junction electrode silver/silver chloride and connected by very sensitive amount of drug [8,9].…”

Section: Apparatusmentioning

confidence: 99%

Carbon Paste Electrodes for Oxomemazine Hydrochloride: Fabrication and Evaluation

et al. 2020

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The evaluation of oxomemazine hydrochloride (OXCl) prepared in carbon paste electrodes is reported in detail. There are many practical techniques and experiments for electrode preparation one of them is mixing of the ion-pair with ion pairing agent. Prepared electrodes gave satisfactory data in ranging from (0.018 to 18.35) mg based on Nernstian cationic slopes, the used electrodes refer to the standard data obtained at (slope 58.7±2.1 mV decade-1) by using sodium tetraphenylborate (NaTPB) and rapid response time equal to 15 s and lifetime approximately equal to (4 weeks). The prepared electrodes can be counted as end point indicator electrode for potentiometric titration of oxomemazine Hydrochloride OXCl resulting in a high percentage of accuracy.

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Novel Metformin Carbon Paste and PVC Electrodes

Cited by 8 publications

References 0 publications

Towards disposable sensors for drug quality control: Dextromethorphan screen‐ printed electrodes

Towards disposable sensors for drug quality control: Dextromethorphan screen‐ printed electrodes

Novel Disposable Potentiometric Sensor for Determination of Granisetron in Surface Water Samples and Pharmaceutical Formulations

Carbon Paste Electrodes for Oxomemazine Hydrochloride: Fabrication and Evaluation

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