Novel charge-transfer complexes of pyrazine Schiff bases derived from 2-aminopyrazine with benzaldehyde and N-4-dimethylaminobenzaldehyde with some aromatic nitro compounds have been synthesized and characterizes experimentally and confirmed theoretically.

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New amineptine hydrochloride (Am-Cl) ion-selective electrodes (conventional type) based on amineptinium-tetraphenylborate (I) and amineptiniumphosphomolybdate (II) were prepared. The electrodes exhibited mean slopes of calibration graphs of 57.9 mV and 53.8 mV per decade of (Am-Cl) concentration at 25 C for electrodes (I) and (II), respectively. The electrodes can be used within the concentration range 3.16Â10 À5 À10 À2 M (Am-Cl) at a pH range of 2.0±3.9 for both electrodes. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coef®cients of the electrodes, which were 0.00172 V C À1 and 0.00091 V C À1 for (I) and (II) electrodes, respectively. The electrodes showed a very good selectivity for (Am-Cl) with respect to a number of inorganic cations and sugars. The standard addition method is successfully applied to determine (Am-Cl) in pure solutions and in amineptine-containing tablets.

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New Plastic membrane ion-selective electrode for trimetazidine dihydrochloride based on trimetazidinium-tetraphenylborate was prepared. The electrode exhibited mean calibration graph slope of 29.5 mV per decade of (TrimCl2) concentration at 25°C. The electrode can be used within the concentration range 3.2×10-5-10-2 M (TrimCl2) at pH ranges of 1.5-3.8 and 4.5-7.5. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coefficient of the electrode, which was (0.00088 V°C-1). The electrode showed a very good selectivity for (TrimCl2) with respect to a number of inorganic cations, sugars and amino acids. The electrode was applied to the potentiometric determination of the trimetazidine ion and its pharmaceutical preparation under batch and flow injection conditions. Graphite coated wire was prepared and characterized as sensor for the drug under investigation. Also, trimetazidine was determined by conductimetric titrations.

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